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Retinal artery occlusion and the 3-year risk of stroke in Taiwan: a nationwide population-based study.
Am J Ophthalmol. 2012 Oct; 154(4):645-652.e1.AJ

Abstract

PURPOSE

To verify the association between retinal artery occlusion (RAO) and stroke with a large-scale nationwide study.

DESIGN

Retrospective nationwide population-based administrative database study.

METHODS

Data were collected from the Longitudinal Health Insurance Database 2000 (LHID2000), which contains claim data from 1 million randomly selected beneficiaries among Taiwan's 23 million residents. The study cohort consisted of all patients with a diagnosis of RAO from January 1999 through December 2006 (n = 464). The control group consisted of randomly selected patients (n = 2748) matched with the study group by age, sex, date of index medical care, and comorbid hypertension. Patients were tracked from their index date for 3 years. The Kaplan-Meier method was used to compute the stroke-free survival rate. Cox proportional hazard regressions were used to compute the adjusted stroke-free survival rate after adjusting for possible confounding factors.

RESULTS

Ninety-one RAO patients (19.61%) and 280 controls (10.05%) had a stroke (P < .0001) during the 3-year follow-up period. Compared with the controls, the incidence rate ratios of stroke in RAO patients were 9.46 at 0-1 month, 5.57 at 1-6 months, and 2.16 at 0-3 years after RAO (P < .0001). After adjusting for age, sex, and selected comorbid disorders, the hazard ratio of having a stroke for RAO patients was still 2.07 times higher than that of controls and 3.34 times higher in the ≤60-year-old subgroup.

CONCLUSIONS

RAO increases the risk for subsequent stroke. Early neurologic evaluation and secondary prevention for stroke are recommended for RAO patients.

Authors+Show Affiliations

Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22809785

Citation

Chang, Yuh-Shin, et al. "Retinal Artery Occlusion and the 3-year Risk of Stroke in Taiwan: a Nationwide Population-based Study." American Journal of Ophthalmology, vol. 154, no. 4, 2012, pp. 645-652.e1.
Chang YS, Jan RL, Weng SF, et al. Retinal artery occlusion and the 3-year risk of stroke in Taiwan: a nationwide population-based study. Am J Ophthalmol. 2012;154(4):645-652.e1.
Chang, Y. S., Jan, R. L., Weng, S. F., Wang, J. J., Chio, C. C., Wei, F. T., & Chu, C. C. (2012). Retinal artery occlusion and the 3-year risk of stroke in Taiwan: a nationwide population-based study. American Journal of Ophthalmology, 154(4), 645-e1. https://doi.org/10.1016/j.ajo.2012.03.046
Chang YS, et al. Retinal Artery Occlusion and the 3-year Risk of Stroke in Taiwan: a Nationwide Population-based Study. Am J Ophthalmol. 2012;154(4):645-652.e1. PubMed PMID: 22809785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal artery occlusion and the 3-year risk of stroke in Taiwan: a nationwide population-based study. AU - Chang,Yuh-Shin, AU - Jan,Ren-Long, AU - Weng,Shih-Feng, AU - Wang,Jhi-Joung, AU - Chio,Chung-Ching, AU - Wei,Fu-Tsung, AU - Chu,Chin-Chen, Y1 - 2012/07/17/ PY - 2012/01/11/received PY - 2012/03/29/revised PY - 2012/03/30/accepted PY - 2012/7/20/entrez PY - 2012/7/20/pubmed PY - 2012/12/14/medline SP - 645 EP - 652.e1 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 154 IS - 4 N2 - PURPOSE: To verify the association between retinal artery occlusion (RAO) and stroke with a large-scale nationwide study. DESIGN: Retrospective nationwide population-based administrative database study. METHODS: Data were collected from the Longitudinal Health Insurance Database 2000 (LHID2000), which contains claim data from 1 million randomly selected beneficiaries among Taiwan's 23 million residents. The study cohort consisted of all patients with a diagnosis of RAO from January 1999 through December 2006 (n = 464). The control group consisted of randomly selected patients (n = 2748) matched with the study group by age, sex, date of index medical care, and comorbid hypertension. Patients were tracked from their index date for 3 years. The Kaplan-Meier method was used to compute the stroke-free survival rate. Cox proportional hazard regressions were used to compute the adjusted stroke-free survival rate after adjusting for possible confounding factors. RESULTS: Ninety-one RAO patients (19.61%) and 280 controls (10.05%) had a stroke (P < .0001) during the 3-year follow-up period. Compared with the controls, the incidence rate ratios of stroke in RAO patients were 9.46 at 0-1 month, 5.57 at 1-6 months, and 2.16 at 0-3 years after RAO (P < .0001). After adjusting for age, sex, and selected comorbid disorders, the hazard ratio of having a stroke for RAO patients was still 2.07 times higher than that of controls and 3.34 times higher in the ≤60-year-old subgroup. CONCLUSIONS: RAO increases the risk for subsequent stroke. Early neurologic evaluation and secondary prevention for stroke are recommended for RAO patients. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/22809785/Retinal_artery_occlusion_and_the_3_year_risk_of_stroke_in_Taiwan:_a_nationwide_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(12)00260-7 DB - PRIME DP - Unbound Medicine ER -