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Total fat intake is associated with decreased mortality in Japanese men but not in women.
J Nutr. 2012 Sep; 142(9):1713-9.JN

Abstract

Dietary guidelines generally recommend avoiding a high-fat diet. However, the relationship between fat subtypes and mortality remains unclear especially in a population with a relatively low intake of fat. We aimed to prospectively examine the relationship between dietary fat intake and all-cause and cause-specific mortality in a Japanese community. In 1992, a total of 28,356 residents of Takayama, Japan, without cancer, stroke, or coronary heart disease, responded to a validated 169-item FFQ. We identified 4616 deaths during a 16-y follow-up. The HR of mortality according to the percentage of energy from the total and subtypes of fat when substituted for an isoenergic quantity of carbohydrate was calculated after controlling for potential confounders. A high intake of total fat and PUFA was associated with a decrease in all-cause mortality in men; the HR for the highest compared with the lowest quintile were 0.83 (95% CI: 0.70, 0.99; P-trend = 0.048) for total fat and 0.77 (95% CI: 0.62, 0.95; P-trend = 0.05) for PUFA. Both fats were associated with a decrease in mortality from cancer and diseases other than cardiovascular disease. In women, a higher SFA intake was associated with higher all-cause mortality [HR = 1.22 (95% CI: 0.99, 1.49; P-trend = 0.03)]. A favorable effect was suggested for total fat and PUFA intakes on mortality in men except for that from cardiovascular disease, whereas increased SFA intake may be associated with adverse health consequences in women.

Authors+Show Affiliations

Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan. chisato@gifu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22810986

Citation

Nagata, Chisato, et al. "Total Fat Intake Is Associated With Decreased Mortality in Japanese Men but Not in Women." The Journal of Nutrition, vol. 142, no. 9, 2012, pp. 1713-9.
Nagata C, Nakamura K, Wada K, et al. Total fat intake is associated with decreased mortality in Japanese men but not in women. J Nutr. 2012;142(9):1713-9.
Nagata, C., Nakamura, K., Wada, K., Oba, S., Tsuji, M., Tamai, Y., & Kawachi, T. (2012). Total fat intake is associated with decreased mortality in Japanese men but not in women. The Journal of Nutrition, 142(9), 1713-9. https://doi.org/10.3945/jn.112.161661
Nagata C, et al. Total Fat Intake Is Associated With Decreased Mortality in Japanese Men but Not in Women. J Nutr. 2012;142(9):1713-9. PubMed PMID: 22810986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total fat intake is associated with decreased mortality in Japanese men but not in women. AU - Nagata,Chisato, AU - Nakamura,Kozue, AU - Wada,Keiko, AU - Oba,Shino, AU - Tsuji,Michiko, AU - Tamai,Yuya, AU - Kawachi,Toshiaki, Y1 - 2012/07/18/ PY - 2012/7/20/entrez PY - 2012/7/20/pubmed PY - 2012/10/31/medline SP - 1713 EP - 9 JF - The Journal of nutrition JO - J. Nutr. VL - 142 IS - 9 N2 - Dietary guidelines generally recommend avoiding a high-fat diet. However, the relationship between fat subtypes and mortality remains unclear especially in a population with a relatively low intake of fat. We aimed to prospectively examine the relationship between dietary fat intake and all-cause and cause-specific mortality in a Japanese community. In 1992, a total of 28,356 residents of Takayama, Japan, without cancer, stroke, or coronary heart disease, responded to a validated 169-item FFQ. We identified 4616 deaths during a 16-y follow-up. The HR of mortality according to the percentage of energy from the total and subtypes of fat when substituted for an isoenergic quantity of carbohydrate was calculated after controlling for potential confounders. A high intake of total fat and PUFA was associated with a decrease in all-cause mortality in men; the HR for the highest compared with the lowest quintile were 0.83 (95% CI: 0.70, 0.99; P-trend = 0.048) for total fat and 0.77 (95% CI: 0.62, 0.95; P-trend = 0.05) for PUFA. Both fats were associated with a decrease in mortality from cancer and diseases other than cardiovascular disease. In women, a higher SFA intake was associated with higher all-cause mortality [HR = 1.22 (95% CI: 0.99, 1.49; P-trend = 0.03)]. A favorable effect was suggested for total fat and PUFA intakes on mortality in men except for that from cardiovascular disease, whereas increased SFA intake may be associated with adverse health consequences in women. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/22810986/Total_fat_intake_is_associated_with_decreased_mortality_in_Japanese_men_but_not_in_women_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.112.161661 DB - PRIME DP - Unbound Medicine ER -