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Shaddock peels (Citrus maxima) phenolic extracts inhibit α-amylase, α-glucosidase and angiotensin I-converting enzyme activities: a nutraceutical approach to diabetes management.
Diabetes Metab Syndr. 2011 Jul-Sep; 5(3):148-52.DM

Abstract

In this study, the interactions of free and bound phenolic-rich extracts from shaddock peels (popular in folklore for the management of diabetes and hypertension) with α-amylase and α-glucosidase (key enzymes linked to type-2 diabetes) and angiotensin I-converting enzyme (ACE) (key enzyme linked to hypertension) were assessed. The free phenolics of shaddock (Citrus maxima) peels were extracted with 80% acetone, while the bound phenolics were extracted from the alkaline and acid hydrolyzed residue with ethyl acetate; and their interaction with the enzymes were assessed. The phenolic extracts inhibited α-amylase, α-glucosidase and ACE enzyme activities in a dose-dependent manner; however, bound phenolics had significantly higher (P<0.05) α-amylase inhibitory activities, than free phenolics, which had significantly higher (P<0.05) ACE inhibitory activities. There was no significant difference (P>0.05) in their α-glucosidase inhibitory activities. The stronger inhibition of α-glucosidase when compared to α-amylase is of great pharmaceutical importance. The phenolic inhibited sodium nitroprusside induced lipid peroxidation in pancreas in a dose dependent manner. Therefore, free and bound phenolic extracts from shaddock peels could be used as nutraceutical for the management of hypertension and type-2 diabetes.

Authors+Show Affiliations

Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria. goboh2001@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22813568

Citation

Oboh, Ganiyu, and Ayokunle O. Ademosun. "Shaddock Peels (Citrus Maxima) Phenolic Extracts Inhibit Α-amylase, Α-glucosidase and Angiotensin I-converting Enzyme Activities: a Nutraceutical Approach to Diabetes Management." Diabetes & Metabolic Syndrome, vol. 5, no. 3, 2011, pp. 148-52.
Oboh G, Ademosun AO. Shaddock peels (Citrus maxima) phenolic extracts inhibit α-amylase, α-glucosidase and angiotensin I-converting enzyme activities: a nutraceutical approach to diabetes management. Diabetes Metab Syndr. 2011;5(3):148-52.
Oboh, G., & Ademosun, A. O. (2011). Shaddock peels (Citrus maxima) phenolic extracts inhibit α-amylase, α-glucosidase and angiotensin I-converting enzyme activities: a nutraceutical approach to diabetes management. Diabetes & Metabolic Syndrome, 5(3), 148-52. https://doi.org/10.1016/j.dsx.2012.02.008
Oboh G, Ademosun AO. Shaddock Peels (Citrus Maxima) Phenolic Extracts Inhibit Α-amylase, Α-glucosidase and Angiotensin I-converting Enzyme Activities: a Nutraceutical Approach to Diabetes Management. Diabetes Metab Syndr. 2011 Jul-Sep;5(3):148-52. PubMed PMID: 22813568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Shaddock peels (Citrus maxima) phenolic extracts inhibit α-amylase, α-glucosidase and angiotensin I-converting enzyme activities: a nutraceutical approach to diabetes management. AU - Oboh,Ganiyu, AU - Ademosun,Ayokunle O, Y1 - 2012/03/15/ PY - 2012/7/21/entrez PY - 2012/7/21/pubmed PY - 2013/4/26/medline SP - 148 EP - 52 JF - Diabetes & metabolic syndrome JO - Diabetes Metab Syndr VL - 5 IS - 3 N2 - In this study, the interactions of free and bound phenolic-rich extracts from shaddock peels (popular in folklore for the management of diabetes and hypertension) with α-amylase and α-glucosidase (key enzymes linked to type-2 diabetes) and angiotensin I-converting enzyme (ACE) (key enzyme linked to hypertension) were assessed. The free phenolics of shaddock (Citrus maxima) peels were extracted with 80% acetone, while the bound phenolics were extracted from the alkaline and acid hydrolyzed residue with ethyl acetate; and their interaction with the enzymes were assessed. The phenolic extracts inhibited α-amylase, α-glucosidase and ACE enzyme activities in a dose-dependent manner; however, bound phenolics had significantly higher (P<0.05) α-amylase inhibitory activities, than free phenolics, which had significantly higher (P<0.05) ACE inhibitory activities. There was no significant difference (P>0.05) in their α-glucosidase inhibitory activities. The stronger inhibition of α-glucosidase when compared to α-amylase is of great pharmaceutical importance. The phenolic inhibited sodium nitroprusside induced lipid peroxidation in pancreas in a dose dependent manner. Therefore, free and bound phenolic extracts from shaddock peels could be used as nutraceutical for the management of hypertension and type-2 diabetes. SN - 1878-0334 UR - https://www.unboundmedicine.com/medline/citation/22813568/Shaddock_peels__Citrus_maxima__phenolic_extracts_inhibit_α_amylase_α_glucosidase_and_angiotensin_I_converting_enzyme_activities:_a_nutraceutical_approach_to_diabetes_management_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1871-4021(12)00009-4 DB - PRIME DP - Unbound Medicine ER -