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Influence of maternal diabetes on serum leptinemic and insulinemic status of the offspring: a case study of selected patients in a tertiary care hospital in Bangladesh.
Diabetes Metab Syndr 2011 Jan-Mar; 5(1):33-7DM

Abstract

INTRODUCTION

Leptin is now known to be an important hormone affecting intrauterine fetal growth. Since growth of fetus is also affected by the glycemic status of the mother. Serum leptin of infant is influenced by the maternal diabetic state. Investigation of cord blood leptin in babies of DM (Diabetes Mellitus) and GDM (Gestational Diabetes Mellitus) mothers (controlled blood glucose levels) may provide some indication about involvement of genetic factor in the development of leptin abnormalities in fetus.

AIM

The study was taken to investigate whether cord blood insulin, c-peptide and leptin levels correlate with birth weight in offspring of DM mother.

METHODS

Blood was drawn from umbilical cord of 30 babies from GDM mothers (GDM-babies), 45 babies from Type 2 DM Mothers (DM-babies), and 30 babies from ND (Nondiabetic) mothers (ND-babies) of term pregnancy. Weight, blood glucose, placenta, serum leptin and c-peptide of the babies were measured.

RESULTS

Birth weight of GDM and DM babies were significantly higher compared to ND-babies. Glucose level in GDM babies was significantly higher than ND and DM babies. Leptin levels in GDM babies were significantly higher than that of ND and DM babies. Serum c-peptide in GDM babies was significantly higher than DM and ND babies. However, there was no significant difference in leptin-glucose ratio among the three groups. Irrespective of degree of hyperglycemia leptin is a major determinant of fetal growth.

CONCLUSIONS

DM mother produces different insulinemic and leptinemic responses in the fetus indicating a possible genetic involvement.

Authors+Show Affiliations

Department of Gynecology & Obstetrics, BIRDEM & IMC, 122 Kazi Nazrul Islam Avenue, Dhaka 1000, Bangladesh. shelly_birdem@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22814839

Citation

Jahan, Samsad, et al. "Influence of Maternal Diabetes On Serum Leptinemic and Insulinemic Status of the Offspring: a Case Study of Selected Patients in a Tertiary Care Hospital in Bangladesh." Diabetes & Metabolic Syndrome, vol. 5, no. 1, 2011, pp. 33-7.
Jahan S, Ahmed CM, Zinnat R, et al. Influence of maternal diabetes on serum leptinemic and insulinemic status of the offspring: a case study of selected patients in a tertiary care hospital in Bangladesh. Diabetes Metab Syndr. 2011;5(1):33-7.
Jahan, S., Ahmed, C. M., Zinnat, R., Hasan, Z., Habib, S. H., Saha, S., & Ali, L. (2011). Influence of maternal diabetes on serum leptinemic and insulinemic status of the offspring: a case study of selected patients in a tertiary care hospital in Bangladesh. Diabetes & Metabolic Syndrome, 5(1), pp. 33-7. doi:10.1016/j.dsx.2010.10.001.
Jahan S, et al. Influence of Maternal Diabetes On Serum Leptinemic and Insulinemic Status of the Offspring: a Case Study of Selected Patients in a Tertiary Care Hospital in Bangladesh. Diabetes Metab Syndr. 2011;5(1):33-7. PubMed PMID: 22814839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of maternal diabetes on serum leptinemic and insulinemic status of the offspring: a case study of selected patients in a tertiary care hospital in Bangladesh. AU - Jahan,Samsad, AU - Ahmed,Chowdhury Meshkat, AU - Zinnat,Rahelee, AU - Hasan,Zahid, AU - Habib,Samira Humaira, AU - Saha,Soma, AU - Ali,Liaquat, Y1 - 2010/11/21/ PY - 2012/7/21/entrez PY - 2011/1/1/pubmed PY - 2013/8/21/medline SP - 33 EP - 7 JF - Diabetes & metabolic syndrome JO - Diabetes Metab Syndr VL - 5 IS - 1 N2 - INTRODUCTION: Leptin is now known to be an important hormone affecting intrauterine fetal growth. Since growth of fetus is also affected by the glycemic status of the mother. Serum leptin of infant is influenced by the maternal diabetic state. Investigation of cord blood leptin in babies of DM (Diabetes Mellitus) and GDM (Gestational Diabetes Mellitus) mothers (controlled blood glucose levels) may provide some indication about involvement of genetic factor in the development of leptin abnormalities in fetus. AIM: The study was taken to investigate whether cord blood insulin, c-peptide and leptin levels correlate with birth weight in offspring of DM mother. METHODS: Blood was drawn from umbilical cord of 30 babies from GDM mothers (GDM-babies), 45 babies from Type 2 DM Mothers (DM-babies), and 30 babies from ND (Nondiabetic) mothers (ND-babies) of term pregnancy. Weight, blood glucose, placenta, serum leptin and c-peptide of the babies were measured. RESULTS: Birth weight of GDM and DM babies were significantly higher compared to ND-babies. Glucose level in GDM babies was significantly higher than ND and DM babies. Leptin levels in GDM babies were significantly higher than that of ND and DM babies. Serum c-peptide in GDM babies was significantly higher than DM and ND babies. However, there was no significant difference in leptin-glucose ratio among the three groups. Irrespective of degree of hyperglycemia leptin is a major determinant of fetal growth. CONCLUSIONS: DM mother produces different insulinemic and leptinemic responses in the fetus indicating a possible genetic involvement. SN - 1878-0334 UR - https://www.unboundmedicine.com/medline/citation/22814839/Influence_of_maternal_diabetes_on_serum_leptinemic_and_insulinemic_status_of_the_offspring:_a_case_study_of_selected_patients_in_a_tertiary_care_hospital_in_Bangladesh_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1871-4021(10)00093-7 DB - PRIME DP - Unbound Medicine ER -