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A peculiar cause of anaphylaxis: no more steak? The journey to discovery of a newly recognized allergy to galactose-alpha-1,3-galactose found in mammalian meat.
J Gen Intern Med 2013; 28(2):322-5JG

Abstract

In recent years, a newly recognized allergic disease has been uncovered, and seemingly idiopathic causes of anaphylaxis now have an explanation. Individuals bitten by the lone star tick may develop IgE antibodies to the carbohydrate galactose-α-1,3-galactose (alpha-gal). Upon exposure of sensitized subjects to mammalian meat containing alpha-gal on glycoproteins or glycolipids, delayed anaphylaxis may ensue, often three to six hours after ingestion.1 Many of these individuals have negative allergy skin prick tests to meat, further obscuring the diagnosis. With the recent development of IgE alpha-gal tests, the clinical diagnosis can be confirmed in the laboratory.

Authors+Show Affiliations

General Internal Medicine, Virginia Commonwealth University, PO BOX 980120, Richmond, VA 23298-0102, USA. swolver@vcu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22815061

Citation

Wolver, Susan E., et al. "A Peculiar Cause of Anaphylaxis: No More Steak? the Journey to Discovery of a Newly Recognized Allergy to Galactose-alpha-1,3-galactose Found in Mammalian Meat." Journal of General Internal Medicine, vol. 28, no. 2, 2013, pp. 322-5.
Wolver SE, Sun DR, Commins SP, et al. A peculiar cause of anaphylaxis: no more steak? The journey to discovery of a newly recognized allergy to galactose-alpha-1,3-galactose found in mammalian meat. J Gen Intern Med. 2013;28(2):322-5.
Wolver, S. E., Sun, D. R., Commins, S. P., & Schwartz, L. B. (2013). A peculiar cause of anaphylaxis: no more steak? The journey to discovery of a newly recognized allergy to galactose-alpha-1,3-galactose found in mammalian meat. Journal of General Internal Medicine, 28(2), pp. 322-5. doi:10.1007/s11606-012-2144-z.
Wolver SE, et al. A Peculiar Cause of Anaphylaxis: No More Steak? the Journey to Discovery of a Newly Recognized Allergy to Galactose-alpha-1,3-galactose Found in Mammalian Meat. J Gen Intern Med. 2013;28(2):322-5. PubMed PMID: 22815061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A peculiar cause of anaphylaxis: no more steak? The journey to discovery of a newly recognized allergy to galactose-alpha-1,3-galactose found in mammalian meat. AU - Wolver,Susan E, AU - Sun,Diane R, AU - Commins,Scott P, AU - Schwartz,Lawrence B, Y1 - 2012/07/20/ PY - 2012/02/28/received PY - 2012/06/08/accepted PY - 2012/05/15/revised PY - 2012/7/21/entrez PY - 2012/7/21/pubmed PY - 2013/8/14/medline SP - 322 EP - 5 JF - Journal of general internal medicine JO - J Gen Intern Med VL - 28 IS - 2 N2 - In recent years, a newly recognized allergic disease has been uncovered, and seemingly idiopathic causes of anaphylaxis now have an explanation. Individuals bitten by the lone star tick may develop IgE antibodies to the carbohydrate galactose-α-1,3-galactose (alpha-gal). Upon exposure of sensitized subjects to mammalian meat containing alpha-gal on glycoproteins or glycolipids, delayed anaphylaxis may ensue, often three to six hours after ingestion.1 Many of these individuals have negative allergy skin prick tests to meat, further obscuring the diagnosis. With the recent development of IgE alpha-gal tests, the clinical diagnosis can be confirmed in the laboratory. SN - 1525-1497 UR - https://www.unboundmedicine.com/medline/citation/22815061/A_peculiar_cause_of_anaphylaxis:_no_more_steak_The_journey_to_discovery_of_a_newly_recognized_allergy_to_galactose_alpha_13_galactose_found_in_mammalian_meat_ L2 - https://dx.doi.org/10.1007/s11606-012-2144-z DB - PRIME DP - Unbound Medicine ER -