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RETRACTED ARTICLE

Depression as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies.
Int J Geriatr Psychiatry 2013; 28(5):441-9IJ

Abstract

BACKGROUND

This study examined whether depression was a risk factor for onset of dementia including Alzheimer's disease (AD), vascular dementia (VD) and any dementia, and mild cognitive impairment (MCI) by using a quantitative meta-analysis of longitudinal studies.

METHODS

EMBASE and MEDLINE were searched for articles published up to February 2011. All studies that examined the relationship between depression and the onset of dementia or MCI were included. Pooled relative risk was calculated using fixed-effects models.

RESULTS

Twelve studies met our inclusion criteria for this meta-analysis. All subjects were without dementia or MCI at baseline. Four, two, five, and four studies compared the incidence of AD, VD, any dementia, and MCI between subjects with or without depression, respectively. After pooling all the studies, subjects with depression had higher incidence of AD (relative risk (RR):1.66, 95% confidence interval (CI): 1.29-2.14), VD (RR: 1.89, 95% CI: 1.19-3.01), any dementia (RR: 1.55, 95% CI: 1.31-2.83), and MCI (RR: 1.97, 95% CI: 1.53-2.54) than those without depression.

CONCLUSIONS

The quantitative meta-analysis showed that depression was a major risk factor for incidence of dementia (including AD, VD, and any dementia) and MCI.

Authors+Show Affiliations

Department of Geriatrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Retracted Publication

Language

eng

PubMed ID

22815126

Citation

Gao, Yuan, et al. "Depression as a Risk Factor for Dementia and Mild Cognitive Impairment: a Meta-analysis of Longitudinal Studies." International Journal of Geriatric Psychiatry, vol. 28, no. 5, 2013, pp. 441-9.
Gao Y, Huang C, Zhao K, et al. Depression as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Int J Geriatr Psychiatry. 2013;28(5):441-9.
Gao, Y., Huang, C., Zhao, K., Ma, L., Qiu, X., Zhang, L., ... Xiao, Q. (2013). Depression as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. International Journal of Geriatric Psychiatry, 28(5), pp. 441-9. doi:10.1002/gps.3845.
Gao Y, et al. Depression as a Risk Factor for Dementia and Mild Cognitive Impairment: a Meta-analysis of Longitudinal Studies. Int J Geriatr Psychiatry. 2013;28(5):441-9. PubMed PMID: 22815126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. AU - Gao,Yuan, AU - Huang,Changquan, AU - Zhao,Kexiang, AU - Ma,Louyan, AU - Qiu,Xuan, AU - Zhang,Lei, AU - Xiu,Yun, AU - Chen,Lin, AU - Lu,Wei, AU - Huang,Chunxia, AU - Tang,Yong, AU - Xiao,Qian, Y1 - 2012/07/19/ PY - 2011/07/21/received PY - 2012/05/09/accepted PY - 2012/7/21/entrez PY - 2012/7/21/pubmed PY - 2013/9/14/medline SP - 441 EP - 9 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 28 IS - 5 N2 - BACKGROUND: This study examined whether depression was a risk factor for onset of dementia including Alzheimer's disease (AD), vascular dementia (VD) and any dementia, and mild cognitive impairment (MCI) by using a quantitative meta-analysis of longitudinal studies. METHODS: EMBASE and MEDLINE were searched for articles published up to February 2011. All studies that examined the relationship between depression and the onset of dementia or MCI were included. Pooled relative risk was calculated using fixed-effects models. RESULTS: Twelve studies met our inclusion criteria for this meta-analysis. All subjects were without dementia or MCI at baseline. Four, two, five, and four studies compared the incidence of AD, VD, any dementia, and MCI between subjects with or without depression, respectively. After pooling all the studies, subjects with depression had higher incidence of AD (relative risk (RR):1.66, 95% confidence interval (CI): 1.29-2.14), VD (RR: 1.89, 95% CI: 1.19-3.01), any dementia (RR: 1.55, 95% CI: 1.31-2.83), and MCI (RR: 1.97, 95% CI: 1.53-2.54) than those without depression. CONCLUSIONS: The quantitative meta-analysis showed that depression was a major risk factor for incidence of dementia (including AD, VD, and any dementia) and MCI. SN - 1099-1166 UR - https://www.unboundmedicine.com/medline/citation/22815126/Depression_as_a_risk_factor_for_dementia_and_mild_cognitive_impairment:_a_meta_analysis_of_longitudinal_studies_ L2 - https://doi.org/10.1002/gps.3845 DB - PRIME DP - Unbound Medicine ER -