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Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery.
Ther Deliv 2010; 1(1):63-73TD

Abstract

AIM

To study the effect of different types of lipid on the entrapment efficiency (EE) and physical stability of repaglinide (RG)-loaded solid lipid nanoparticles (SLNs). RG-loaded SLNs were prepared by modified solvent injection method using stearic acid (RSA), glycerol monosteratae (RGM), glyceryl behenate (RGB) and tristearin (RTS). Poloxamer F68 was used as a stabilizer.

RESULTS

SLNs were characterized by particle size, zeta-potential, EE, in vitro release, solid-state properties (differential scanning calorimetry, transmission electron microscopy and electron diffraction) and stability at 30 degrees C/65% relative humidity for 3 months. The mean particle size and zeta-potential of RG-loaded SLNs prepared with different lipids in varying concentrations ranged from 150 to 355 nm and -21.04 +/- 3.10 to -30.54 +/- 2.76 mV, respectively.

CONCLUSION

EE was found to vary with lipids in the following order: RSA < RGM < RGB < RTS. Tristearin-prepared SLNs showed a significant prolonged drug release up to 24 h. Differential scanning calorimetry and electron diffraction microphotograph results indicated that RG entrapped in the SLNs existed in an amorphous or molecular state. SLNs prepared with stearic acid, glycerol monostearate and glyceryl behenate after storage showed significant increases in particle size, polydispersity index and EE. The SLNs prepared with tristearin were stable.

Authors+Show Affiliations

Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi- 221005, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22816120

Citation

Rawat, Manoj K., et al. "Effect of Lipid Matrix On Repaglinide-loaded Solid Lipid Nanoparticles for Oral Delivery." Therapeutic Delivery, vol. 1, no. 1, 2010, pp. 63-73.
Rawat MK, Jain A, Mishra A, et al. Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery. Ther Deliv. 2010;1(1):63-73.
Rawat, M. K., Jain, A., Mishra, A., Muthu, M. S., & Singh, S. (2010). Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery. Therapeutic Delivery, 1(1), pp. 63-73.
Rawat MK, et al. Effect of Lipid Matrix On Repaglinide-loaded Solid Lipid Nanoparticles for Oral Delivery. Ther Deliv. 2010;1(1):63-73. PubMed PMID: 22816120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery. AU - Rawat,Manoj K, AU - Jain,Achint, AU - Mishra,Amit, AU - Muthu,Madaswamy S, AU - Singh,Sanjay, PY - 2012/7/21/entrez PY - 2010/7/1/pubmed PY - 2012/8/10/medline SP - 63 EP - 73 JF - Therapeutic delivery JO - Ther Deliv VL - 1 IS - 1 N2 - AIM: To study the effect of different types of lipid on the entrapment efficiency (EE) and physical stability of repaglinide (RG)-loaded solid lipid nanoparticles (SLNs). RG-loaded SLNs were prepared by modified solvent injection method using stearic acid (RSA), glycerol monosteratae (RGM), glyceryl behenate (RGB) and tristearin (RTS). Poloxamer F68 was used as a stabilizer. RESULTS: SLNs were characterized by particle size, zeta-potential, EE, in vitro release, solid-state properties (differential scanning calorimetry, transmission electron microscopy and electron diffraction) and stability at 30 degrees C/65% relative humidity for 3 months. The mean particle size and zeta-potential of RG-loaded SLNs prepared with different lipids in varying concentrations ranged from 150 to 355 nm and -21.04 +/- 3.10 to -30.54 +/- 2.76 mV, respectively. CONCLUSION: EE was found to vary with lipids in the following order: RSA < RGM < RGB < RTS. Tristearin-prepared SLNs showed a significant prolonged drug release up to 24 h. Differential scanning calorimetry and electron diffraction microphotograph results indicated that RG entrapped in the SLNs existed in an amorphous or molecular state. SLNs prepared with stearic acid, glycerol monostearate and glyceryl behenate after storage showed significant increases in particle size, polydispersity index and EE. The SLNs prepared with tristearin were stable. SN - 2041-5990 UR - https://www.unboundmedicine.com/medline/citation/22816120/Effect_of_lipid_matrix_on_repaglinide_loaded_solid_lipid_nanoparticles_for_oral_delivery_ L2 - https://www.future-science.com/doi/full/10.4155/tde.10.7?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -