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Biventricular structural and functional responses to aortic constriction in a rabbit model of chronic right ventricular pressure overload.
J Thorac Cardiovasc Surg. 2012 Dec; 144(6):1494-501.JT

Abstract

OBJECTIVES

Chronic right ventricular (RV) pressure overload results in pathologic RV hypertrophy and diminished RV function. Although aortic constriction has been shown to improve systolic function in acute RV failure, its effect on RV responses to chronic pressure overload is unknown.

METHODS

Adjustable vascular banding devices were placed on the main pulmonary artery and descending aorta. In 5 animals (sham group), neither band was inflated. In 9 animals (PAB group), only the pulmonary arterial band was inflated, with adjustments on a weekly basis to generate systemic or suprasystemic RV pressure at 28 days. In 9 animals, both pulmonary arterial and aortic devices were inflated (PAB + AO group), the pulmonary arterial band as for the PAB group and the aortic band adjusted to increase proximal systolic blood pressure by approximately 20 mm Hg. Effects on the functional performance were assessed 5 weeks after surgery by conductance catheters, followed by histologic and molecular assessment.

RESULTS

Contractile performance was significantly improved in the PAB + AO group versus the PAB group for both ventricles. Relative to sham-operated animals, both banding groups showed significant differences in myocardial histologic and molecular responses. Relative to the PAB group, the PAB + AO group showed significantly decreased RV cardiomyocyte diameter, decreased RV collagen content, and reduced RV expression of endothelin receptor type B, matrix metalloproteinase 9, and transforming growth factor β genes.

CONCLUSIONS

Aortic constriction in an experimental model of chronic RV pressure overload not only resulted in improved biventricular systolic function but also improved myocardial remodeling. These data suggest that chronically increased left ventricular afterload leads to a more physiologically hypertrophic response in the pressure-overloaded RV.

Authors+Show Affiliations

Division of Cardiology, Hospital for Sick Children, University of Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22818124

Citation

Apitz, Christian, et al. "Biventricular Structural and Functional Responses to Aortic Constriction in a Rabbit Model of Chronic Right Ventricular Pressure Overload." The Journal of Thoracic and Cardiovascular Surgery, vol. 144, no. 6, 2012, pp. 1494-501.
Apitz C, Honjo O, Humpl T, et al. Biventricular structural and functional responses to aortic constriction in a rabbit model of chronic right ventricular pressure overload. J Thorac Cardiovasc Surg. 2012;144(6):1494-501.
Apitz, C., Honjo, O., Humpl, T., Li, J., Assad, R. S., Cho, M. Y., Hong, J., Friedberg, M. K., & Redington, A. N. (2012). Biventricular structural and functional responses to aortic constriction in a rabbit model of chronic right ventricular pressure overload. The Journal of Thoracic and Cardiovascular Surgery, 144(6), 1494-501. https://doi.org/10.1016/j.jtcvs.2012.06.027
Apitz C, et al. Biventricular Structural and Functional Responses to Aortic Constriction in a Rabbit Model of Chronic Right Ventricular Pressure Overload. J Thorac Cardiovasc Surg. 2012;144(6):1494-501. PubMed PMID: 22818124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biventricular structural and functional responses to aortic constriction in a rabbit model of chronic right ventricular pressure overload. AU - Apitz,Christian, AU - Honjo,Osami, AU - Humpl,Tilman, AU - Li,Jing, AU - Assad,Renato S, AU - Cho,Mi Y, AU - Hong,James, AU - Friedberg,Mark K, AU - Redington,Andrew N, Y1 - 2012/07/18/ PY - 2012/03/19/received PY - 2012/05/09/revised PY - 2012/06/12/accepted PY - 2012/7/24/entrez PY - 2012/7/24/pubmed PY - 2013/1/23/medline SP - 1494 EP - 501 JF - The Journal of thoracic and cardiovascular surgery JO - J. Thorac. Cardiovasc. Surg. VL - 144 IS - 6 N2 - OBJECTIVES: Chronic right ventricular (RV) pressure overload results in pathologic RV hypertrophy and diminished RV function. Although aortic constriction has been shown to improve systolic function in acute RV failure, its effect on RV responses to chronic pressure overload is unknown. METHODS: Adjustable vascular banding devices were placed on the main pulmonary artery and descending aorta. In 5 animals (sham group), neither band was inflated. In 9 animals (PAB group), only the pulmonary arterial band was inflated, with adjustments on a weekly basis to generate systemic or suprasystemic RV pressure at 28 days. In 9 animals, both pulmonary arterial and aortic devices were inflated (PAB + AO group), the pulmonary arterial band as for the PAB group and the aortic band adjusted to increase proximal systolic blood pressure by approximately 20 mm Hg. Effects on the functional performance were assessed 5 weeks after surgery by conductance catheters, followed by histologic and molecular assessment. RESULTS: Contractile performance was significantly improved in the PAB + AO group versus the PAB group for both ventricles. Relative to sham-operated animals, both banding groups showed significant differences in myocardial histologic and molecular responses. Relative to the PAB group, the PAB + AO group showed significantly decreased RV cardiomyocyte diameter, decreased RV collagen content, and reduced RV expression of endothelin receptor type B, matrix metalloproteinase 9, and transforming growth factor β genes. CONCLUSIONS: Aortic constriction in an experimental model of chronic RV pressure overload not only resulted in improved biventricular systolic function but also improved myocardial remodeling. These data suggest that chronically increased left ventricular afterload leads to a more physiologically hypertrophic response in the pressure-overloaded RV. SN - 1097-685X UR - https://www.unboundmedicine.com/medline/citation/22818124/Biventricular_structural_and_functional_responses_to_aortic_constriction_in_a_rabbit_model_of_chronic_right_ventricular_pressure_overload_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5223(12)00705-2 DB - PRIME DP - Unbound Medicine ER -