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Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder.

Abstract

Studies investigating the impact of cannabis use on bipolar clinical characteristics and neurocognition are limited. The objective of the present study was to compare clinical and neurocognitive measures in individuals with bipolar disorder with a history of cannabis use disorder (CUD) versus those without a history of CUD. We conducted a retrospective analysis of a large cohort (N=200) of bipolar I subjects, either with (CUD+; N=50) or without (CUD-; N=150) a history of CUD. We compared the groups on clinical and demographic variables, as well as on performance on neurocognitive tests. Patient groups did not differ regarding age, age of onset or global assessment of functioning. Compared to the CUD- group, the CUD+ group had a higher proportion of men and a higher proportion of patients with a history of psychosis. CUD+ subjects demonstrated significantly better performance on measures of attention, processing speed, and working memory. The history of CUD is associated with history of psychosis, suggestive of poorer clinical prognosis. Interestingly, bipolar patients with history of CUD had better neurocognitive performance as compared to patients with no history of CUD.

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  • Authors+Show Affiliations

    ,

    The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Department of Psychiatry Research, Glen Oaks, NY, USA. rbraga@nshs.edu

    , ,

    Source

    Psychiatry research 200:2-3 2012 Dec 30 pg 242-5

    MeSH

    Adult
    Attention
    Bipolar Disorder
    Cognition
    Executive Function
    Female
    Humans
    Male
    Marijuana Abuse
    Marijuana Smoking
    Memory, Short-Term
    Middle Aged
    Neuropsychological Tests
    Prognosis
    Retrospective Studies

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    22818174

    Citation

    Braga, Raphael J., et al. "Cognitive and Clinical Outcomes Associated With Cannabis Use in Patients With Bipolar I Disorder." Psychiatry Research, vol. 200, no. 2-3, 2012, pp. 242-5.
    Braga RJ, Burdick KE, Derosse P, et al. Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder. Psychiatry Res. 2012;200(2-3):242-5.
    Braga, R. J., Burdick, K. E., Derosse, P., & Malhotra, A. K. (2012). Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder. Psychiatry Research, 200(2-3), pp. 242-5. doi:10.1016/j.psychres.2012.05.025.
    Braga RJ, et al. Cognitive and Clinical Outcomes Associated With Cannabis Use in Patients With Bipolar I Disorder. Psychiatry Res. 2012 Dec 30;200(2-3):242-5. PubMed PMID: 22818174.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder. AU - Braga,Raphael J, AU - Burdick,Katherine E, AU - Derosse,Pamela, AU - Malhotra,Anil K, Y1 - 2012/07/18/ PY - 2011/06/10/received PY - 2012/03/21/revised PY - 2012/05/24/accepted PY - 2012/7/24/entrez PY - 2012/7/24/pubmed PY - 2013/5/18/medline SP - 242 EP - 5 JF - Psychiatry research JO - Psychiatry Res VL - 200 IS - 2-3 N2 - Studies investigating the impact of cannabis use on bipolar clinical characteristics and neurocognition are limited. The objective of the present study was to compare clinical and neurocognitive measures in individuals with bipolar disorder with a history of cannabis use disorder (CUD) versus those without a history of CUD. We conducted a retrospective analysis of a large cohort (N=200) of bipolar I subjects, either with (CUD+; N=50) or without (CUD-; N=150) a history of CUD. We compared the groups on clinical and demographic variables, as well as on performance on neurocognitive tests. Patient groups did not differ regarding age, age of onset or global assessment of functioning. Compared to the CUD- group, the CUD+ group had a higher proportion of men and a higher proportion of patients with a history of psychosis. CUD+ subjects demonstrated significantly better performance on measures of attention, processing speed, and working memory. The history of CUD is associated with history of psychosis, suggestive of poorer clinical prognosis. Interestingly, bipolar patients with history of CUD had better neurocognitive performance as compared to patients with no history of CUD. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/22818174/Cognitive_and_clinical_outcomes_associated_with_cannabis_use_in_patients_with_bipolar_I_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(12)00300-9 DB - PRIME DP - Unbound Medicine ER -