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Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder.
Psychiatry Res 2012; 200(2-3):242-5PR

Abstract

Studies investigating the impact of cannabis use on bipolar clinical characteristics and neurocognition are limited. The objective of the present study was to compare clinical and neurocognitive measures in individuals with bipolar disorder with a history of cannabis use disorder (CUD) versus those without a history of CUD. We conducted a retrospective analysis of a large cohort (N=200) of bipolar I subjects, either with (CUD+; N=50) or without (CUD-; N=150) a history of CUD. We compared the groups on clinical and demographic variables, as well as on performance on neurocognitive tests. Patient groups did not differ regarding age, age of onset or global assessment of functioning. Compared to the CUD- group, the CUD+ group had a higher proportion of men and a higher proportion of patients with a history of psychosis. CUD+ subjects demonstrated significantly better performance on measures of attention, processing speed, and working memory. The history of CUD is associated with history of psychosis, suggestive of poorer clinical prognosis. Interestingly, bipolar patients with history of CUD had better neurocognitive performance as compared to patients with no history of CUD.

Authors+Show Affiliations

The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Department of Psychiatry Research, Glen Oaks, NY, USA. rbraga@nshs.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22818174

Citation

Braga, Raphael J., et al. "Cognitive and Clinical Outcomes Associated With Cannabis Use in Patients With Bipolar I Disorder." Psychiatry Research, vol. 200, no. 2-3, 2012, pp. 242-5.
Braga RJ, Burdick KE, Derosse P, et al. Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder. Psychiatry Res. 2012;200(2-3):242-5.
Braga, R. J., Burdick, K. E., Derosse, P., & Malhotra, A. K. (2012). Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder. Psychiatry Research, 200(2-3), pp. 242-5. doi:10.1016/j.psychres.2012.05.025.
Braga RJ, et al. Cognitive and Clinical Outcomes Associated With Cannabis Use in Patients With Bipolar I Disorder. Psychiatry Res. 2012 Dec 30;200(2-3):242-5. PubMed PMID: 22818174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder. AU - Braga,Raphael J, AU - Burdick,Katherine E, AU - Derosse,Pamela, AU - Malhotra,Anil K, Y1 - 2012/07/18/ PY - 2011/06/10/received PY - 2012/03/21/revised PY - 2012/05/24/accepted PY - 2012/7/24/entrez PY - 2012/7/24/pubmed PY - 2013/5/18/medline SP - 242 EP - 5 JF - Psychiatry research JO - Psychiatry Res VL - 200 IS - 2-3 N2 - Studies investigating the impact of cannabis use on bipolar clinical characteristics and neurocognition are limited. The objective of the present study was to compare clinical and neurocognitive measures in individuals with bipolar disorder with a history of cannabis use disorder (CUD) versus those without a history of CUD. We conducted a retrospective analysis of a large cohort (N=200) of bipolar I subjects, either with (CUD+; N=50) or without (CUD-; N=150) a history of CUD. We compared the groups on clinical and demographic variables, as well as on performance on neurocognitive tests. Patient groups did not differ regarding age, age of onset or global assessment of functioning. Compared to the CUD- group, the CUD+ group had a higher proportion of men and a higher proportion of patients with a history of psychosis. CUD+ subjects demonstrated significantly better performance on measures of attention, processing speed, and working memory. The history of CUD is associated with history of psychosis, suggestive of poorer clinical prognosis. Interestingly, bipolar patients with history of CUD had better neurocognitive performance as compared to patients with no history of CUD. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/22818174/Cognitive_and_clinical_outcomes_associated_with_cannabis_use_in_patients_with_bipolar_I_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(12)00300-9 DB - PRIME DP - Unbound Medicine ER -