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Statins are diabetogenic--myth or reality?
Atheroscler Suppl 2012; 13(1):1-10AS

Abstract

Multiple clinical trials have demonstrated the beneficial effects of statins in lowering levels of low-density lipoprotein and in the prevention of cardiovascular disease. However, although statins have a good safety profile, a debate has been ongoing as to whether use of statins increases risk of new-onset diabetes. Recent large scale meta-analyses of statin trials support the concept of a diabetogenic effect of statins, as do some other small trials assessing changes in glycaemia parameters and insulin levels. However, a definitive mechanism of action has not yet been elucidated. Nevertheless, the level of evidence has been sufficient to lead the FDA to make a change to the labelling of statins. This review assesses the current available evidence and offers a clinical perspective.

Authors+Show Affiliations

Institute of Cardiovascular & Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University Of Glasgow, 126 University Place, Glasgow G12 8TA, UK. naveed.sattar@glasgow.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22818818

Citation

Sattar, Naveed, and Marja-Riitta Taskinen. "Statins Are Diabetogenic--myth or Reality?" Atherosclerosis. Supplements, vol. 13, no. 1, 2012, pp. 1-10.
Sattar N, Taskinen MR. Statins are diabetogenic--myth or reality? Atheroscler Suppl. 2012;13(1):1-10.
Sattar, N., & Taskinen, M. R. (2012). Statins are diabetogenic--myth or reality? Atherosclerosis. Supplements, 13(1), pp. 1-10. doi:10.1016/j.atherosclerosissup.2012.06.001.
Sattar N, Taskinen MR. Statins Are Diabetogenic--myth or Reality. Atheroscler Suppl. 2012;13(1):1-10. PubMed PMID: 22818818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statins are diabetogenic--myth or reality? AU - Sattar,Naveed, AU - Taskinen,Marja-Riitta, Y1 - 2012/07/19/ PY - 2012/7/24/entrez PY - 2012/7/24/pubmed PY - 2012/11/14/medline SP - 1 EP - 10 JF - Atherosclerosis. Supplements JO - Atheroscler Suppl VL - 13 IS - 1 N2 - Multiple clinical trials have demonstrated the beneficial effects of statins in lowering levels of low-density lipoprotein and in the prevention of cardiovascular disease. However, although statins have a good safety profile, a debate has been ongoing as to whether use of statins increases risk of new-onset diabetes. Recent large scale meta-analyses of statin trials support the concept of a diabetogenic effect of statins, as do some other small trials assessing changes in glycaemia parameters and insulin levels. However, a definitive mechanism of action has not yet been elucidated. Nevertheless, the level of evidence has been sufficient to lead the FDA to make a change to the labelling of statins. This review assesses the current available evidence and offers a clinical perspective. SN - 1878-5050 UR - https://www.unboundmedicine.com/medline/citation/22818818/Statins_are_diabetogenic__myth_or_reality L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5688(12)00002-5 DB - PRIME DP - Unbound Medicine ER -