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Eosinophilic pustular folliculitis of infancy: a series of 15 cases and review of the literature.
J Am Acad Dermatol. 2013 Jan; 68(1):150-5.JA

Abstract

BACKGROUND

Eosinophilic pustular folliculitis (EPF) of infancy is characterized by the presence of pustular lesions containing eosinophils. It is the least well-characterized of the EPF diseases.

OBJECTIVES

We sought to define the clinical and histopathologic features of the condition.

METHODS

We conducted a retrospective review of the clinical data and histologic findings of 15 patients given the diagnosis of EPF of infancy at the Hospital Niño Jesús, Madrid, Spain, from 1995 to 2011, and of patient data published in MEDLINE with such a diagnosis from the disease description (1984-2011).

RESULTS

A total of 61 cases were collected. The disease was more common in males than females (ratio 4:1), and presented before 14 months of life in 95% of cases (mean 6.1 months; median 5 months). All patients had recurrent outbreaks and scalp involvement, and 65% had lesions on areas of the body other than the scalp. Tissue eosinophilia was present in all cases; however, true follicular involvement was observed only in 62% of cases in which histologic study was available. More than 80% of the patients were cured by 3 years of age (mean 25.3 months; median 18 months). Topical steroids were effective in 90% of cases.

LIMITATIONS

This was a retrospective study.

CONCLUSIONS

EPF of infancy presents most often in the first 14 months of life and usually resolves by 3 years of age. All patients showed scalp involvement, tissue eosinophilia, and recurrent outbreaks. The condition does not require aggressive treatment, as it is benign and self-limiting.

Authors+Show Affiliations

Department of Dermatology, Hospital Niño Jesús, Madrid, Spain. ahernandez_hnj@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22819356

Citation

Hernández-Martín, Ángela, et al. "Eosinophilic Pustular Folliculitis of Infancy: a Series of 15 Cases and Review of the Literature." Journal of the American Academy of Dermatology, vol. 68, no. 1, 2013, pp. 150-5.
Hernández-Martín Á, Nuño-González A, Colmenero I, et al. Eosinophilic pustular folliculitis of infancy: a series of 15 cases and review of the literature. J Am Acad Dermatol. 2013;68(1):150-5.
Hernández-Martín, Á., Nuño-González, A., Colmenero, I., & Torrelo, A. (2013). Eosinophilic pustular folliculitis of infancy: a series of 15 cases and review of the literature. Journal of the American Academy of Dermatology, 68(1), 150-5. https://doi.org/10.1016/j.jaad.2012.05.025
Hernández-Martín Á, et al. Eosinophilic Pustular Folliculitis of Infancy: a Series of 15 Cases and Review of the Literature. J Am Acad Dermatol. 2013;68(1):150-5. PubMed PMID: 22819356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eosinophilic pustular folliculitis of infancy: a series of 15 cases and review of the literature. AU - Hernández-Martín,Ángela, AU - Nuño-González,Almudena, AU - Colmenero,Isabel, AU - Torrelo,Antonio, Y1 - 2012/07/21/ PY - 2012/03/01/received PY - 2012/05/13/revised PY - 2012/05/22/accepted PY - 2012/7/24/entrez PY - 2012/7/24/pubmed PY - 2013/2/28/medline SP - 150 EP - 5 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 68 IS - 1 N2 - BACKGROUND: Eosinophilic pustular folliculitis (EPF) of infancy is characterized by the presence of pustular lesions containing eosinophils. It is the least well-characterized of the EPF diseases. OBJECTIVES: We sought to define the clinical and histopathologic features of the condition. METHODS: We conducted a retrospective review of the clinical data and histologic findings of 15 patients given the diagnosis of EPF of infancy at the Hospital Niño Jesús, Madrid, Spain, from 1995 to 2011, and of patient data published in MEDLINE with such a diagnosis from the disease description (1984-2011). RESULTS: A total of 61 cases were collected. The disease was more common in males than females (ratio 4:1), and presented before 14 months of life in 95% of cases (mean 6.1 months; median 5 months). All patients had recurrent outbreaks and scalp involvement, and 65% had lesions on areas of the body other than the scalp. Tissue eosinophilia was present in all cases; however, true follicular involvement was observed only in 62% of cases in which histologic study was available. More than 80% of the patients were cured by 3 years of age (mean 25.3 months; median 18 months). Topical steroids were effective in 90% of cases. LIMITATIONS: This was a retrospective study. CONCLUSIONS: EPF of infancy presents most often in the first 14 months of life and usually resolves by 3 years of age. All patients showed scalp involvement, tissue eosinophilia, and recurrent outbreaks. The condition does not require aggressive treatment, as it is benign and self-limiting. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/22819356/Eosinophilic_pustular_folliculitis_of_infancy:_a_series_of_15_cases_and_review_of_the_literature_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(12)00585-3 DB - PRIME DP - Unbound Medicine ER -