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Decreased expression of pigment epithelium-derived factor and increased microvascular density in ovarian endometriotic lesions in women with endometriosis.
Eur J Obstet Gynecol Reprod Biol. 2012 Nov; 165(1):104-9.EJ

Abstract

OBJECTIVES

To determine whether women with endometriosis have altered expression of pigment epithelium-derived factor (PEDF) in ovarian endometriotic lesions as compared to women without endometriosis.

STUDY DESIGN

Ectopic and eutopic and normal endometrial tissues were sampled from 40 women with ovarian endometriosis and 20 control women, respectively. Endometrial PEDF expression and microvascular density (MVD) using an antibody to von Willebrand factor (vWF) and alpha-smooth muscle actin (α-SMA) were evaluated by using immunohistochemical staining.

RESULTS

We detected decreased PEDF expression and increased MVD using anti-vWF and -α-SMA in ovarian endometriotic lesions in women with endometriosis compared with the control group. In women with endometriosis, the MVD using anti-vWF and -α-SMA but not PEDF expression in ovarian endometriotic lesions correlated with the size of ovarian endometriotic cysts and the severity of the disease. Moreover, the MVD using anti-vWF was negatively correlated with PEDF expression in control endometrium but not in ovarian endometriotic lesions.

CONCLUSIONS

Our results suggest that decreased PEDF expression and increased MVD in ovarian endometriotic lesions might play an important role in the pathogenesis of ovarian endometriosis.

Authors+Show Affiliations

Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310006, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22819570

Citation

Huang, Xiufeng, et al. "Decreased Expression of Pigment Epithelium-derived Factor and Increased Microvascular Density in Ovarian Endometriotic Lesions in Women With Endometriosis." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 165, no. 1, 2012, pp. 104-9.
Huang X, Chen L, Fu G, et al. Decreased expression of pigment epithelium-derived factor and increased microvascular density in ovarian endometriotic lesions in women with endometriosis. Eur J Obstet Gynecol Reprod Biol. 2012;165(1):104-9.
Huang, X., Chen, L., Fu, G., Xu, H., & Zhang, X. (2012). Decreased expression of pigment epithelium-derived factor and increased microvascular density in ovarian endometriotic lesions in women with endometriosis. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 165(1), 104-9. https://doi.org/10.1016/j.ejogrb.2012.06.034
Huang X, et al. Decreased Expression of Pigment Epithelium-derived Factor and Increased Microvascular Density in Ovarian Endometriotic Lesions in Women With Endometriosis. Eur J Obstet Gynecol Reprod Biol. 2012;165(1):104-9. PubMed PMID: 22819570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased expression of pigment epithelium-derived factor and increased microvascular density in ovarian endometriotic lesions in women with endometriosis. AU - Huang,Xiufeng, AU - Chen,Liqing, AU - Fu,Guofang, AU - Xu,Hong, AU - Zhang,Xinmei, Y1 - 2012/07/21/ PY - 2011/12/21/received PY - 2012/05/31/revised PY - 2012/06/30/accepted PY - 2012/7/24/entrez PY - 2012/7/24/pubmed PY - 2013/4/23/medline SP - 104 EP - 9 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur. J. Obstet. Gynecol. Reprod. Biol. VL - 165 IS - 1 N2 - OBJECTIVES: To determine whether women with endometriosis have altered expression of pigment epithelium-derived factor (PEDF) in ovarian endometriotic lesions as compared to women without endometriosis. STUDY DESIGN: Ectopic and eutopic and normal endometrial tissues were sampled from 40 women with ovarian endometriosis and 20 control women, respectively. Endometrial PEDF expression and microvascular density (MVD) using an antibody to von Willebrand factor (vWF) and alpha-smooth muscle actin (α-SMA) were evaluated by using immunohistochemical staining. RESULTS: We detected decreased PEDF expression and increased MVD using anti-vWF and -α-SMA in ovarian endometriotic lesions in women with endometriosis compared with the control group. In women with endometriosis, the MVD using anti-vWF and -α-SMA but not PEDF expression in ovarian endometriotic lesions correlated with the size of ovarian endometriotic cysts and the severity of the disease. Moreover, the MVD using anti-vWF was negatively correlated with PEDF expression in control endometrium but not in ovarian endometriotic lesions. CONCLUSIONS: Our results suggest that decreased PEDF expression and increased MVD in ovarian endometriotic lesions might play an important role in the pathogenesis of ovarian endometriosis. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/22819570/Decreased_expression_of_pigment_epithelium_derived_factor_and_increased_microvascular_density_in_ovarian_endometriotic_lesions_in_women_with_endometriosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(12)00302-8 DB - PRIME DP - Unbound Medicine ER -