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Relationship between fatigue and gait abnormality in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type.
Res Dev Disabil 2012 Nov-Dec; 33(6):1914-8RD

Abstract

Ehlers-Danlos syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterised by joint hypermobility, skin hyperextensibility and tissue fragility. It has recently been shown that muscle weakness occurs frequently in EDS, and that fatigue is a common and clinically important symptom. The aim of this study was to investigate the relationship between fatigue severity and the gait pattern using 3D Gait Analysis (GA). Eleven individuals with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility type (JHS/EDS-HT) were investigated using muscle strength measured with standardised questionnaire measuring fatigue (Fatigue Severity Scale, FSS) and quantitative 3D GA. Our data showed that FSS value well correlated with the peak of vertical component of ground reaction force (r=-0.66, p<0.05). The negative correlation gives evidence that the higher the fatigue is the more reduced force is during gait. Our results showed that the ground reaction force has been applied as a functional evaluation score for detecting pathology in gait of JHS/EDS-HT participants and the found correlation between vertical force and fatigue demonstrated that muscle fatigue may be associated with a loss of proprioceptive acuity in lower limb muscles.

Authors+Show Affiliations

Physical Medicine and Rehabilitation Division, Orthopaedic Department, Umberto I Hospital, Sapienza University, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22819599

Citation

Celletti, Claudia, et al. "Relationship Between Fatigue and Gait Abnormality in Joint Hypermobility syndrome/Ehlers-Danlos Syndrome Hypermobility Type." Research in Developmental Disabilities, vol. 33, no. 6, 2012, pp. 1914-8.
Celletti C, Galli M, Cimolin V, et al. Relationship between fatigue and gait abnormality in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type. Res Dev Disabil. 2012;33(6):1914-8.
Celletti, C., Galli, M., Cimolin, V., Castori, M., Albertini, G., & Camerota, F. (2012). Relationship between fatigue and gait abnormality in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type. Research in Developmental Disabilities, 33(6), pp. 1914-8. doi:10.1016/j.ridd.2012.06.018.
Celletti C, et al. Relationship Between Fatigue and Gait Abnormality in Joint Hypermobility syndrome/Ehlers-Danlos Syndrome Hypermobility Type. Res Dev Disabil. 2012;33(6):1914-8. PubMed PMID: 22819599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between fatigue and gait abnormality in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type. AU - Celletti,Claudia, AU - Galli,Manuela, AU - Cimolin,Veronica, AU - Castori,Marco, AU - Albertini,Giorgio, AU - Camerota,Filippo, Y1 - 2012/07/21/ PY - 2012/05/21/received PY - 2012/06/29/revised PY - 2012/06/29/accepted PY - 2012/7/24/entrez PY - 2012/7/24/pubmed PY - 2013/3/30/medline SP - 1914 EP - 8 JF - Research in developmental disabilities JO - Res Dev Disabil VL - 33 IS - 6 N2 - Ehlers-Danlos syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterised by joint hypermobility, skin hyperextensibility and tissue fragility. It has recently been shown that muscle weakness occurs frequently in EDS, and that fatigue is a common and clinically important symptom. The aim of this study was to investigate the relationship between fatigue severity and the gait pattern using 3D Gait Analysis (GA). Eleven individuals with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility type (JHS/EDS-HT) were investigated using muscle strength measured with standardised questionnaire measuring fatigue (Fatigue Severity Scale, FSS) and quantitative 3D GA. Our data showed that FSS value well correlated with the peak of vertical component of ground reaction force (r=-0.66, p<0.05). The negative correlation gives evidence that the higher the fatigue is the more reduced force is during gait. Our results showed that the ground reaction force has been applied as a functional evaluation score for detecting pathology in gait of JHS/EDS-HT participants and the found correlation between vertical force and fatigue demonstrated that muscle fatigue may be associated with a loss of proprioceptive acuity in lower limb muscles. SN - 1873-3379 UR - https://www.unboundmedicine.com/medline/citation/22819599/Relationship_between_fatigue_and_gait_abnormality_in_joint_hypermobility_syndrome/Ehlers_Danlos_syndrome_hypermobility_type_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-4222(12)00166-7 DB - PRIME DP - Unbound Medicine ER -