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Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: a case-case comparison, case-control study.

Abstract

INTRODUCTION

We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010-2011 influenza season.

METHODS

We conducted a prospective case-control study in five hospitals, in Valencia, Spain. Study subjects were consecutive emergency hospitalizations for predefined conditions associated with an influenza-like illness episode <8 days before admission. Patients were considered immunized if vaccinated ≥14 days before influenza-like illness onset. Cases were those with a real time reverse transcriptase polymerase chain reaction (RT-PCR) positive for influenza and controls were RT-PCR positive for other respiratory viruses. Adjusted IVE was estimated as 100×(1-adjusted odds ratio). To account for indication bias we computed adjusted IVE for respiratory syncytial virus related hospitalizations.

RESULTS

Of 826 eligible hospitalized patients, 102 (12%) were influenza positive and considered cases, and 116 (14%) were positive for other respiratory viruses and considered controls. Adjusted IVE was 54% (95% confidence interval, 11-76%). By subgroup, adjusted IVE was 53% (4-77%) for those with high-risk conditions, 59% (16-79%) for those ≥60 years of age, and, 54% (4-79%) for those ≥60 years of age with high-risk conditions. No influenza vaccine effect was observed against respiratory syncytial virus related hospitalization.

CONCLUSION

Influenza vaccination was associated with a significant reduction on the risk of confirmed influenza hospitalization, irrespective of age and high-risk conditions.

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  • Authors+Show Affiliations

    ,

    Centro Superior de Investigación en Salud Pública CSISP, Valencia, Spain. puig joa@gva.es

    , , , , , , , ,

    Source

    Vaccine 30:39 2012 Aug 24 pg 5714-20

    MeSH

    Adolescent
    Adult
    Aged
    Case-Control Studies
    Female
    Hospitalization
    Humans
    Influenza Vaccines
    Influenza, Human
    Male
    Middle Aged
    Prospective Studies
    Risk Factors
    Spain
    Vaccination
    Young Adult

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22819720

    Citation

    Puig-Barberà, J, et al. "Effectiveness of the 2010-2011 Seasonal Influenza Vaccine in Preventing Confirmed Influenza Hospitalizations in Adults: a Case-case Comparison, Case-control Study." Vaccine, vol. 30, no. 39, 2012, pp. 5714-20.
    Puig-Barberà J, Díez-Domingo J, Arnedo-Pena A, et al. Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: a case-case comparison, case-control study. Vaccine. 2012;30(39):5714-20.
    Puig-Barberà, J., Díez-Domingo, J., Arnedo-Pena, A., Ruiz-García, M., Pérez-Vilar, S., Micó-Esparza, J. L., ... Schwarz-Chavarri, H. (2012). Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: a case-case comparison, case-control study. Vaccine, 30(39), pp. 5714-20. doi:10.1016/j.vaccine.2012.07.006.
    Puig-Barberà J, et al. Effectiveness of the 2010-2011 Seasonal Influenza Vaccine in Preventing Confirmed Influenza Hospitalizations in Adults: a Case-case Comparison, Case-control Study. Vaccine. 2012 Aug 24;30(39):5714-20. PubMed PMID: 22819720.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: a case-case comparison, case-control study. AU - Puig-Barberà,J, AU - Díez-Domingo,J, AU - Arnedo-Pena,A, AU - Ruiz-García,M, AU - Pérez-Vilar,S, AU - Micó-Esparza,J L, AU - Belenguer-Varea,A, AU - Carratalá-Munuera,C, AU - Gil-Guillén,V, AU - Schwarz-Chavarri,H, Y1 - 2012/07/20/ PY - 2012/05/28/received PY - 2012/07/01/revised PY - 2012/07/06/accepted PY - 2012/7/24/entrez PY - 2012/7/24/pubmed PY - 2012/12/18/medline SP - 5714 EP - 20 JF - Vaccine JO - Vaccine VL - 30 IS - 39 N2 - INTRODUCTION: We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010-2011 influenza season. METHODS: We conducted a prospective case-control study in five hospitals, in Valencia, Spain. Study subjects were consecutive emergency hospitalizations for predefined conditions associated with an influenza-like illness episode <8 days before admission. Patients were considered immunized if vaccinated ≥14 days before influenza-like illness onset. Cases were those with a real time reverse transcriptase polymerase chain reaction (RT-PCR) positive for influenza and controls were RT-PCR positive for other respiratory viruses. Adjusted IVE was estimated as 100×(1-adjusted odds ratio). To account for indication bias we computed adjusted IVE for respiratory syncytial virus related hospitalizations. RESULTS: Of 826 eligible hospitalized patients, 102 (12%) were influenza positive and considered cases, and 116 (14%) were positive for other respiratory viruses and considered controls. Adjusted IVE was 54% (95% confidence interval, 11-76%). By subgroup, adjusted IVE was 53% (4-77%) for those with high-risk conditions, 59% (16-79%) for those ≥60 years of age, and, 54% (4-79%) for those ≥60 years of age with high-risk conditions. No influenza vaccine effect was observed against respiratory syncytial virus related hospitalization. CONCLUSION: Influenza vaccination was associated with a significant reduction on the risk of confirmed influenza hospitalization, irrespective of age and high-risk conditions. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/22819720/Effectiveness_of_the_2010_2011_seasonal_influenza_vaccine_in_preventing_confirmed_influenza_hospitalizations_in_adults:_a_case_case_comparison_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(12)01007-9 DB - PRIME DP - Unbound Medicine ER -