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Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: a case-case comparison, case-control study.
Vaccine 2012; 30(39):5714-20V

Abstract

INTRODUCTION

We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010-2011 influenza season.

METHODS

We conducted a prospective case-control study in five hospitals, in Valencia, Spain. Study subjects were consecutive emergency hospitalizations for predefined conditions associated with an influenza-like illness episode <8 days before admission. Patients were considered immunized if vaccinated ≥14 days before influenza-like illness onset. Cases were those with a real time reverse transcriptase polymerase chain reaction (RT-PCR) positive for influenza and controls were RT-PCR positive for other respiratory viruses. Adjusted IVE was estimated as 100×(1-adjusted odds ratio). To account for indication bias we computed adjusted IVE for respiratory syncytial virus related hospitalizations.

RESULTS

Of 826 eligible hospitalized patients, 102 (12%) were influenza positive and considered cases, and 116 (14%) were positive for other respiratory viruses and considered controls. Adjusted IVE was 54% (95% confidence interval, 11-76%). By subgroup, adjusted IVE was 53% (4-77%) for those with high-risk conditions, 59% (16-79%) for those ≥60 years of age, and, 54% (4-79%) for those ≥60 years of age with high-risk conditions. No influenza vaccine effect was observed against respiratory syncytial virus related hospitalization.

CONCLUSION

Influenza vaccination was associated with a significant reduction on the risk of confirmed influenza hospitalization, irrespective of age and high-risk conditions.

Authors+Show Affiliations

Centro Superior de Investigación en Salud Pública CSISP, Valencia, Spain. puig joa@gva.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22819720

Citation

Puig-Barberà, J, et al. "Effectiveness of the 2010-2011 Seasonal Influenza Vaccine in Preventing Confirmed Influenza Hospitalizations in Adults: a Case-case Comparison, Case-control Study." Vaccine, vol. 30, no. 39, 2012, pp. 5714-20.
Puig-Barberà J, Díez-Domingo J, Arnedo-Pena A, et al. Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: a case-case comparison, case-control study. Vaccine. 2012;30(39):5714-20.
Puig-Barberà, J., Díez-Domingo, J., Arnedo-Pena, A., Ruiz-García, M., Pérez-Vilar, S., Micó-Esparza, J. L., ... Schwarz-Chavarri, H. (2012). Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: a case-case comparison, case-control study. Vaccine, 30(39), pp. 5714-20. doi:10.1016/j.vaccine.2012.07.006.
Puig-Barberà J, et al. Effectiveness of the 2010-2011 Seasonal Influenza Vaccine in Preventing Confirmed Influenza Hospitalizations in Adults: a Case-case Comparison, Case-control Study. Vaccine. 2012 Aug 24;30(39):5714-20. PubMed PMID: 22819720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: a case-case comparison, case-control study. AU - Puig-Barberà,J, AU - Díez-Domingo,J, AU - Arnedo-Pena,A, AU - Ruiz-García,M, AU - Pérez-Vilar,S, AU - Micó-Esparza,J L, AU - Belenguer-Varea,A, AU - Carratalá-Munuera,C, AU - Gil-Guillén,V, AU - Schwarz-Chavarri,H, Y1 - 2012/07/20/ PY - 2012/05/28/received PY - 2012/07/01/revised PY - 2012/07/06/accepted PY - 2012/7/24/entrez PY - 2012/7/24/pubmed PY - 2012/12/18/medline SP - 5714 EP - 20 JF - Vaccine JO - Vaccine VL - 30 IS - 39 N2 - INTRODUCTION: We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010-2011 influenza season. METHODS: We conducted a prospective case-control study in five hospitals, in Valencia, Spain. Study subjects were consecutive emergency hospitalizations for predefined conditions associated with an influenza-like illness episode <8 days before admission. Patients were considered immunized if vaccinated ≥14 days before influenza-like illness onset. Cases were those with a real time reverse transcriptase polymerase chain reaction (RT-PCR) positive for influenza and controls were RT-PCR positive for other respiratory viruses. Adjusted IVE was estimated as 100×(1-adjusted odds ratio). To account for indication bias we computed adjusted IVE for respiratory syncytial virus related hospitalizations. RESULTS: Of 826 eligible hospitalized patients, 102 (12%) were influenza positive and considered cases, and 116 (14%) were positive for other respiratory viruses and considered controls. Adjusted IVE was 54% (95% confidence interval, 11-76%). By subgroup, adjusted IVE was 53% (4-77%) for those with high-risk conditions, 59% (16-79%) for those ≥60 years of age, and, 54% (4-79%) for those ≥60 years of age with high-risk conditions. No influenza vaccine effect was observed against respiratory syncytial virus related hospitalization. CONCLUSION: Influenza vaccination was associated with a significant reduction on the risk of confirmed influenza hospitalization, irrespective of age and high-risk conditions. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/22819720/Effectiveness_of_the_2010_2011_seasonal_influenza_vaccine_in_preventing_confirmed_influenza_hospitalizations_in_adults:_a_case_case_comparison_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(12)01007-9 DB - PRIME DP - Unbound Medicine ER -