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Intake of trans fatty acids from partially hydrogenated vegetable and fish oils and ruminant fat in relation to cancer risk.
Int J Cancer 2013; 132(6):1389-403IJ

Abstract

Intake of trans fatty acids (TFA) may influence systemic inflammation, insulin resistance and adiposity, but whether TFA intake influences cancer risk is insufficiently studied. We examined the association between TFA intake from partially hydrogenated vegetable oils (PHVO-TFA), partially hydrogenated fish oils (PHFO-TFA), and ruminant fat (rTFA) and cancer risk in the Norwegian counties study, a large cohort study with a participation rate >80%. TFA intake was assessed three times in 1974-1988 by questionnaire. A total of 77,568 men and women were followed up through 2007, during which time 12,004 cancer cases occurred. Hazard ratios (HRs) and confidence intervals (CIs) were estimated with Cox regression for cancer sites with ≥150 cases during follow-up. Significantly increased or decreased risks were found when comparing the highest and lowest intake categories (HRs, 95% CIs) for PHVO-TFA and pancreatic cancer in men (0.52, 0.31-0.87) and non-Hodgkin lymphoma (NHL) in both genders (0.70, 0.50-0.98); PHFO-TFA and rectal cancer (1.43, 1.09-1.88), prostate cancer (0.82, 0.69-0.96), and multiple myeloma (2.02, 1.24-3.28); and rTFA and all cancers (1.09, 1.02-1.16), cancer of the mouth/pharynx (1.59, 1.08-2.35), NHL (1.47, 1.06-2.04) and multiple myeloma (0.45, 0.24-0.84). Furthermore, positive trends were found for PHFO-TFA and stomach cancer (p(trend) = 0.01) and rTFA and postmenopausal breast cancer (p(trend) = 0.03). Inverse trends were found for PHVO-TFA and all cancers (p(trend) = 0.006) and cancer of the central nervous system in women (p(trend) = 0.005). PHFO-TFA, but not PHVO-TFA, seemed to increase cancer risk. The increased risks observed for rTFA may be linked to saturated fat.

Authors+Show Affiliations

Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. ida.laake@medisin.uio.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22821174

Citation

Laake, Ida, et al. "Intake of Trans Fatty Acids From Partially Hydrogenated Vegetable and Fish Oils and Ruminant Fat in Relation to Cancer Risk." International Journal of Cancer, vol. 132, no. 6, 2013, pp. 1389-403.
Laake I, Carlsen MH, Pedersen JI, et al. Intake of trans fatty acids from partially hydrogenated vegetable and fish oils and ruminant fat in relation to cancer risk. Int J Cancer. 2013;132(6):1389-403.
Laake, I., Carlsen, M. H., Pedersen, J. I., Weiderpass, E., Selmer, R., Kirkhus, B., ... Veierød, M. B. (2013). Intake of trans fatty acids from partially hydrogenated vegetable and fish oils and ruminant fat in relation to cancer risk. International Journal of Cancer, 132(6), pp. 1389-403. doi:10.1002/ijc.27737.
Laake I, et al. Intake of Trans Fatty Acids From Partially Hydrogenated Vegetable and Fish Oils and Ruminant Fat in Relation to Cancer Risk. Int J Cancer. 2013 Mar 15;132(6):1389-403. PubMed PMID: 22821174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of trans fatty acids from partially hydrogenated vegetable and fish oils and ruminant fat in relation to cancer risk. AU - Laake,Ida, AU - Carlsen,Monica H, AU - Pedersen,Jan I, AU - Weiderpass,Elisabete, AU - Selmer,Randi, AU - Kirkhus,Bente, AU - Thune,Inger, AU - Veierød,Marit B, Y1 - 2012/08/12/ PY - 2012/04/13/received PY - 2012/07/02/accepted PY - 2012/7/24/entrez PY - 2012/7/24/pubmed PY - 2013/3/21/medline SP - 1389 EP - 403 JF - International journal of cancer JO - Int. J. Cancer VL - 132 IS - 6 N2 - Intake of trans fatty acids (TFA) may influence systemic inflammation, insulin resistance and adiposity, but whether TFA intake influences cancer risk is insufficiently studied. We examined the association between TFA intake from partially hydrogenated vegetable oils (PHVO-TFA), partially hydrogenated fish oils (PHFO-TFA), and ruminant fat (rTFA) and cancer risk in the Norwegian counties study, a large cohort study with a participation rate >80%. TFA intake was assessed three times in 1974-1988 by questionnaire. A total of 77,568 men and women were followed up through 2007, during which time 12,004 cancer cases occurred. Hazard ratios (HRs) and confidence intervals (CIs) were estimated with Cox regression for cancer sites with ≥150 cases during follow-up. Significantly increased or decreased risks were found when comparing the highest and lowest intake categories (HRs, 95% CIs) for PHVO-TFA and pancreatic cancer in men (0.52, 0.31-0.87) and non-Hodgkin lymphoma (NHL) in both genders (0.70, 0.50-0.98); PHFO-TFA and rectal cancer (1.43, 1.09-1.88), prostate cancer (0.82, 0.69-0.96), and multiple myeloma (2.02, 1.24-3.28); and rTFA and all cancers (1.09, 1.02-1.16), cancer of the mouth/pharynx (1.59, 1.08-2.35), NHL (1.47, 1.06-2.04) and multiple myeloma (0.45, 0.24-0.84). Furthermore, positive trends were found for PHFO-TFA and stomach cancer (p(trend) = 0.01) and rTFA and postmenopausal breast cancer (p(trend) = 0.03). Inverse trends were found for PHVO-TFA and all cancers (p(trend) = 0.006) and cancer of the central nervous system in women (p(trend) = 0.005). PHFO-TFA, but not PHVO-TFA, seemed to increase cancer risk. The increased risks observed for rTFA may be linked to saturated fat. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/22821174/Intake_of_trans_fatty_acids_from_partially_hydrogenated_vegetable_and_fish_oils_and_ruminant_fat_in_relation_to_cancer_risk_ L2 - https://doi.org/10.1002/ijc.27737 DB - PRIME DP - Unbound Medicine ER -