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CNS toxoplasmosis presenting with obstructive hydrocephalus in patients of retroviral disease--a case series.

Abstract

CNS toxoplasmosis presenting as hydrocephalus is a very rare entity. We present three cases of HIV positive patients whose brain imaging revealed hydrocephalus and who improved with anti toxoplasma medication along with intravenous steroids and did not require any CSF shunting procedures. The mechanism of hydrocephalus in CNS toxoplasmosis is usually due to compression of CSF outflow pathway by ring enhancing lesions but even in their absence hydrocephalus can be rarely seen due to ventriculitis. Hence in HIV positive patients with unexplained hydrocephalus CNS toxoplasmosis should be considered and such patients if started on treatment early have a good prognosis without requiring neurosurgical intervention.

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  • Authors+Show Affiliations

    ,

    Medical College (affiliated to Manipal University), Pediatrics, KMC Hospital, N G Road, Attavar, Mangalore, Karnataka 575001 India.

    , ,

    Source

    The Medical journal of Malaysia 67:2 2012 Apr pg 214-6

    MeSH

    AIDS-Related Opportunistic Infections
    Adult
    Antiretroviral Therapy, Highly Active
    Diagnosis, Differential
    Humans
    Hydrocephalus
    Male
    Neuroimaging
    Tomography, X-Ray Computed
    Toxoplasmosis, Cerebral

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    22822648

    Citation

    Basavaprabhu, A, et al. "CNS Toxoplasmosis Presenting With Obstructive Hydrocephalus in Patients of Retroviral Disease--a Case Series." The Medical Journal of Malaysia, vol. 67, no. 2, 2012, pp. 214-6.
    Basavaprabhu A, Soundarya M, Deepak M, et al. CNS toxoplasmosis presenting with obstructive hydrocephalus in patients of retroviral disease--a case series. Med J Malaysia. 2012;67(2):214-6.
    Basavaprabhu, A., Soundarya, M., Deepak, M., & Satish, R. (2012). CNS toxoplasmosis presenting with obstructive hydrocephalus in patients of retroviral disease--a case series. The Medical Journal of Malaysia, 67(2), pp. 214-6.
    Basavaprabhu A, et al. CNS Toxoplasmosis Presenting With Obstructive Hydrocephalus in Patients of Retroviral Disease--a Case Series. Med J Malaysia. 2012;67(2):214-6. PubMed PMID: 22822648.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - CNS toxoplasmosis presenting with obstructive hydrocephalus in patients of retroviral disease--a case series. AU - Basavaprabhu,A, AU - Soundarya,M, AU - Deepak,M, AU - Satish,R, PY - 2012/7/25/entrez PY - 2012/7/25/pubmed PY - 2012/9/21/medline SP - 214 EP - 6 JF - The Medical journal of Malaysia JO - Med. J. Malaysia VL - 67 IS - 2 N2 - CNS toxoplasmosis presenting as hydrocephalus is a very rare entity. We present three cases of HIV positive patients whose brain imaging revealed hydrocephalus and who improved with anti toxoplasma medication along with intravenous steroids and did not require any CSF shunting procedures. The mechanism of hydrocephalus in CNS toxoplasmosis is usually due to compression of CSF outflow pathway by ring enhancing lesions but even in their absence hydrocephalus can be rarely seen due to ventriculitis. Hence in HIV positive patients with unexplained hydrocephalus CNS toxoplasmosis should be considered and such patients if started on treatment early have a good prognosis without requiring neurosurgical intervention. SN - 0300-5283 UR - https://www.unboundmedicine.com/medline/citation/22822648/CNS_toxoplasmosis_presenting_with_obstructive_hydrocephalus_in_patients_of_retroviral_disease__a_case_series_ L2 - http://www.e-mjm.org/2012/v67n2/CNS-toxoplasmosis.pdf DB - PRIME DP - Unbound Medicine ER -