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Clinical outcome after surgical or percutaneous revascularization in coronary bypass graft failure.
J Cardiovasc Med (Hagerstown). 2013 Jun; 14(6):438-45.JC

Abstract

AIMS

To describe long-term outcome following surgical and percutaneous revascularization in graft failure.

METHODS

We analyzed consecutive patients with graft failure after heart-team assignment to percutaneous coronary intervention (PCI) or redo coronary artery bypass grafting (CABG) between 2003 and 2008. The primary endpoint was the composite of death, myocardial infarction (MI) or target vessel revascularization (TVR). Kaplan-Meier event rate estimates were calculated up to a 5-year follow-up. Independent predictors for outcomes were identified by backward selection in a multivariable Cox proportional hazard model.

RESULTS

We identified 287 patients treated for graft failure: 243 with PCI and 44 with redo CABG. Patients undergoing PCI more frequently presented with ST-elevated myocardial infarction (STEMI) (P < 0.001), multivessel disease (P < 0.001), vein graft failure (P = 0.04), a history of MI (P < 0.001) and shorter time-to-graft failure (P = 0.001). Bare-metal stents (BMS) were used in 81.3% of the PCI-treated lesions and drug-eluting stents (DES) in 18.7%. The median follow-up was 3.9 years. Five-year rate of composite all-cause death, MI or TVR was 57.6% after PCI and 51% after CABG (P = 0.51). Repeat revascularization [TVR and target lesion revascularization (TLR)] was 30.7 and 21.3% after PCI, and 8.0 and 3.2% following CABG (P = 0.009; P = 0.008). In the PCI group, BMS was associated with higher rates of TVR (35.1 vs. 12.6%; P = 0.04) and TLR (24.8 vs. 7.6%; P = 0.04), but similar rate of death or MI compared with DES. Independent predictors for the primary outcome were creatinine [hazard ratio 1.008 per μmol/l, 95% confidence interval (CI) 1.005-1.011, P < 0.001] and peak creatine kinase MB (hazard ratio 1.001 per U/l, 95% CI 1.000-1.002, P = 0.027).

CONCLUSION

Clinical outcomes are similarly poor after heart-team triage for surgical or percutaneous intervention in patients with graft failure. Repeat revascularization occurred more frequent after PCI, particularly following BMS implantation.

Authors+Show Affiliations

Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22828774

Citation

Harskamp, Ralf E., et al. "Clinical Outcome After Surgical or Percutaneous Revascularization in Coronary Bypass Graft Failure." Journal of Cardiovascular Medicine (Hagerstown, Md.), vol. 14, no. 6, 2013, pp. 438-45.
Harskamp RE, Beijk MA, Damman P, et al. Clinical outcome after surgical or percutaneous revascularization in coronary bypass graft failure. J Cardiovasc Med (Hagerstown). 2013;14(6):438-45.
Harskamp, R. E., Beijk, M. A., Damman, P., Kuijt, W. J., Woudstra, P., Grundeken, M. J., Kloek, J. J., Tijssen, J. G., de Mol, B. A., & de Winter, R. J. (2013). Clinical outcome after surgical or percutaneous revascularization in coronary bypass graft failure. Journal of Cardiovascular Medicine (Hagerstown, Md.), 14(6), 438-45. https://doi.org/10.2459/JCM.0b013e328356a4fc
Harskamp RE, et al. Clinical Outcome After Surgical or Percutaneous Revascularization in Coronary Bypass Graft Failure. J Cardiovasc Med (Hagerstown). 2013;14(6):438-45. PubMed PMID: 22828774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical outcome after surgical or percutaneous revascularization in coronary bypass graft failure. AU - Harskamp,Ralf E, AU - Beijk,Marcel A, AU - Damman,Peter, AU - Kuijt,Wichert J, AU - Woudstra,Pier, AU - Grundeken,Maik J, AU - Kloek,Jaap J, AU - Tijssen,Jan G, AU - de Mol,Bas A, AU - de Winter,Robbert J, PY - 2012/7/26/entrez PY - 2012/7/26/pubmed PY - 2013/11/5/medline SP - 438 EP - 45 JF - Journal of cardiovascular medicine (Hagerstown, Md.) JO - J Cardiovasc Med (Hagerstown) VL - 14 IS - 6 N2 - AIMS: To describe long-term outcome following surgical and percutaneous revascularization in graft failure. METHODS: We analyzed consecutive patients with graft failure after heart-team assignment to percutaneous coronary intervention (PCI) or redo coronary artery bypass grafting (CABG) between 2003 and 2008. The primary endpoint was the composite of death, myocardial infarction (MI) or target vessel revascularization (TVR). Kaplan-Meier event rate estimates were calculated up to a 5-year follow-up. Independent predictors for outcomes were identified by backward selection in a multivariable Cox proportional hazard model. RESULTS: We identified 287 patients treated for graft failure: 243 with PCI and 44 with redo CABG. Patients undergoing PCI more frequently presented with ST-elevated myocardial infarction (STEMI) (P < 0.001), multivessel disease (P < 0.001), vein graft failure (P = 0.04), a history of MI (P < 0.001) and shorter time-to-graft failure (P = 0.001). Bare-metal stents (BMS) were used in 81.3% of the PCI-treated lesions and drug-eluting stents (DES) in 18.7%. The median follow-up was 3.9 years. Five-year rate of composite all-cause death, MI or TVR was 57.6% after PCI and 51% after CABG (P = 0.51). Repeat revascularization [TVR and target lesion revascularization (TLR)] was 30.7 and 21.3% after PCI, and 8.0 and 3.2% following CABG (P = 0.009; P = 0.008). In the PCI group, BMS was associated with higher rates of TVR (35.1 vs. 12.6%; P = 0.04) and TLR (24.8 vs. 7.6%; P = 0.04), but similar rate of death or MI compared with DES. Independent predictors for the primary outcome were creatinine [hazard ratio 1.008 per μmol/l, 95% confidence interval (CI) 1.005-1.011, P < 0.001] and peak creatine kinase MB (hazard ratio 1.001 per U/l, 95% CI 1.000-1.002, P = 0.027). CONCLUSION: Clinical outcomes are similarly poor after heart-team triage for surgical or percutaneous intervention in patients with graft failure. Repeat revascularization occurred more frequent after PCI, particularly following BMS implantation. SN - 1558-2035 UR - https://www.unboundmedicine.com/medline/citation/22828774/Clinical_outcome_after_surgical_or_percutaneous_revascularization_in_coronary_bypass_graft_failure_ L2 - http://dx.doi.org/10.2459/JCM.0b013e328356a4fc DB - PRIME DP - Unbound Medicine ER -