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Serum 25-hydroxyvitamin D, vitamin A, and lung cancer mortality in the US population: a potential nutrient-nutrient interaction.
Cancer Causes Control. 2012 Sep; 23(9):1557-65.CC

Abstract

OBJECTIVE

Excess vitamin A may interrupt vitamin D-mediated transcription of target genes. This study investigated whether serum 25-hydroxyvitamin D [25(OH)D] concentrations were associated with lung cancer mortality, and whether this association varied by excess circulating vitamin A and vitamin A/β-carotene supplement use.

METHOD

We analyzed 16,693 men and women in the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994. Lung cancer mortality (n = 258, 104 were former smokers and 23 were never smokers) were identified through National Death Index as of 2006. Serum 25(OH)D was measured by a radioimmunoassay. Vitamin A biomarkers including serum retinol, β-carotene, and retinyl esters were measured by HPLC. Supplement use for the past month was obtained by self-report. Multivariate-adjusted hazard ratios (HR) were estimated by Cox proportional hazard models.

RESULTS

There was no association of serum 25(OH)D with overall lung cancer mortality. Among nonsmokers, ≥44 vs. <44 nmol/L of serum 25(OH)D was associated with a decreased risk (HR = 0.53, 95 % CI = 0.31-0.92, former/never smokers and HR = 0.31, 95 % CI = 0.13-0.77, distant-former [quit ≥20 years]/never smokers). The associations were not observed among participants with excess circulating vitamin A (serum retinyl esters ≥7.0 μg/dL or the ratio of retinyl esters to retinol ≥0.08) or vitamin A/β-carotene supplement users. However, statistical evidence to support effect modification of vitamin A was less clear.

CONCLUSIONS

Serum 25(OH)D concentrations were inversely associated with lung cancer mortality in nonsmokers. The beneficial association was diminished among those with excess circulating vitamin A or vitamin A/β-carotene supplement users.

Authors+Show Affiliations

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4B402, Seattle, WA 98109-1024, USA. tcheng@fhcrc.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22829430

Citation

Cheng, Ting-Yuan David, and Marian L. Neuhouser. "Serum 25-hydroxyvitamin D, Vitamin A, and Lung Cancer Mortality in the US Population: a Potential Nutrient-nutrient Interaction." Cancer Causes & Control : CCC, vol. 23, no. 9, 2012, pp. 1557-65.
Cheng TY, Neuhouser ML. Serum 25-hydroxyvitamin D, vitamin A, and lung cancer mortality in the US population: a potential nutrient-nutrient interaction. Cancer Causes Control. 2012;23(9):1557-65.
Cheng, T. Y., & Neuhouser, M. L. (2012). Serum 25-hydroxyvitamin D, vitamin A, and lung cancer mortality in the US population: a potential nutrient-nutrient interaction. Cancer Causes & Control : CCC, 23(9), 1557-65. https://doi.org/10.1007/s10552-012-0033-8
Cheng TY, Neuhouser ML. Serum 25-hydroxyvitamin D, Vitamin A, and Lung Cancer Mortality in the US Population: a Potential Nutrient-nutrient Interaction. Cancer Causes Control. 2012;23(9):1557-65. PubMed PMID: 22829430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D, vitamin A, and lung cancer mortality in the US population: a potential nutrient-nutrient interaction. AU - Cheng,Ting-Yuan David, AU - Neuhouser,Marian L, Y1 - 2012/07/25/ PY - 2011/10/12/received PY - 2012/07/11/accepted PY - 2012/7/26/entrez PY - 2012/7/26/pubmed PY - 2013/3/19/medline SP - 1557 EP - 65 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 23 IS - 9 N2 - OBJECTIVE: Excess vitamin A may interrupt vitamin D-mediated transcription of target genes. This study investigated whether serum 25-hydroxyvitamin D [25(OH)D] concentrations were associated with lung cancer mortality, and whether this association varied by excess circulating vitamin A and vitamin A/β-carotene supplement use. METHOD: We analyzed 16,693 men and women in the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994. Lung cancer mortality (n = 258, 104 were former smokers and 23 were never smokers) were identified through National Death Index as of 2006. Serum 25(OH)D was measured by a radioimmunoassay. Vitamin A biomarkers including serum retinol, β-carotene, and retinyl esters were measured by HPLC. Supplement use for the past month was obtained by self-report. Multivariate-adjusted hazard ratios (HR) were estimated by Cox proportional hazard models. RESULTS: There was no association of serum 25(OH)D with overall lung cancer mortality. Among nonsmokers, ≥44 vs. <44 nmol/L of serum 25(OH)D was associated with a decreased risk (HR = 0.53, 95 % CI = 0.31-0.92, former/never smokers and HR = 0.31, 95 % CI = 0.13-0.77, distant-former [quit ≥20 years]/never smokers). The associations were not observed among participants with excess circulating vitamin A (serum retinyl esters ≥7.0 μg/dL or the ratio of retinyl esters to retinol ≥0.08) or vitamin A/β-carotene supplement users. However, statistical evidence to support effect modification of vitamin A was less clear. CONCLUSIONS: Serum 25(OH)D concentrations were inversely associated with lung cancer mortality in nonsmokers. The beneficial association was diminished among those with excess circulating vitamin A or vitamin A/β-carotene supplement users. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/22829430/Serum_25_hydroxyvitamin_D_vitamin_A_and_lung_cancer_mortality_in_the_US_population:_a_potential_nutrient_nutrient_interaction_ L2 - https://doi.org/10.1007/s10552-012-0033-8 DB - PRIME DP - Unbound Medicine ER -