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Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period.
J Infect Dis. 2013 May 01; 207(9):1433-41.JI

Abstract

Human rhinovirus (HRV) replication triggers exacerbation of asthma and causes most acute respiratory illnesses (ARIs), which may manifest as influenza-like illness. The recent assignment of 60 previously unknown HRV types to a third HRV species, Human rhinovirus C, raised questions about the prevalence of these picornavirus types in the community, the extent of HRV diversity at a single site, and whether the HRVs have an equally diverse clinical impact on their hosts. We quantified HRV diversity, and there was no clinical impact attributable to HRV species and genotypes among a community population of preschool-aged children with ARI who provided respiratory samples during 2003. All HRV species were represented among 138 children with ARI, and 74 distinct HRV types were cocirculating. Fever accompanied 32.8% of HRV-positive ARI cases. HRVs were less likely than DNA viruses to be codetected with another virus, suggesting virus interference at the community level, demonstrated by the inverse correlation between influenza virus detection and HRV detection.

Authors+Show Affiliations

Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's Medical Research Institute, Sir Albert Sakzewski Virus Research Centre, Children's Health Queensland Hospital and Health Service, University of Queensland, Herston, Australia. ian.mackay@uq.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22829638

Citation

Mackay, Ian M., et al. "Community-wide, Contemporaneous Circulation of a Broad Spectrum of Human Rhinoviruses in Healthy Australian Preschool-aged Children During a 12-month Period." The Journal of Infectious Diseases, vol. 207, no. 9, 2013, pp. 1433-41.
Mackay IM, Lambert SB, Faux CE, et al. Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period. J Infect Dis. 2013;207(9):1433-41.
Mackay, I. M., Lambert, S. B., Faux, C. E., Arden, K. E., Nissen, M. D., Sloots, T. P., & Nolan, T. M. (2013). Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period. The Journal of Infectious Diseases, 207(9), 1433-41. https://doi.org/10.1093/infdis/jis476
Mackay IM, et al. Community-wide, Contemporaneous Circulation of a Broad Spectrum of Human Rhinoviruses in Healthy Australian Preschool-aged Children During a 12-month Period. J Infect Dis. 2013 May 1;207(9):1433-41. PubMed PMID: 22829638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period. AU - Mackay,Ian M, AU - Lambert,Stephen B, AU - Faux,Cassandra E, AU - Arden,Katherine E, AU - Nissen,Michael D, AU - Sloots,Theo P, AU - Nolan,Terence M, Y1 - 2012/07/24/ PY - 2012/7/26/entrez PY - 2012/7/26/pubmed PY - 2013/5/23/medline SP - 1433 EP - 41 JF - The Journal of infectious diseases JO - J Infect Dis VL - 207 IS - 9 N2 - Human rhinovirus (HRV) replication triggers exacerbation of asthma and causes most acute respiratory illnesses (ARIs), which may manifest as influenza-like illness. The recent assignment of 60 previously unknown HRV types to a third HRV species, Human rhinovirus C, raised questions about the prevalence of these picornavirus types in the community, the extent of HRV diversity at a single site, and whether the HRVs have an equally diverse clinical impact on their hosts. We quantified HRV diversity, and there was no clinical impact attributable to HRV species and genotypes among a community population of preschool-aged children with ARI who provided respiratory samples during 2003. All HRV species were represented among 138 children with ARI, and 74 distinct HRV types were cocirculating. Fever accompanied 32.8% of HRV-positive ARI cases. HRVs were less likely than DNA viruses to be codetected with another virus, suggesting virus interference at the community level, demonstrated by the inverse correlation between influenza virus detection and HRV detection. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/22829638/Community_wide_contemporaneous_circulation_of_a_broad_spectrum_of_human_rhinoviruses_in_healthy_Australian_preschool_aged_children_during_a_12_month_period_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jis476 DB - PRIME DP - Unbound Medicine ER -