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Impact of diabetes duration and chronic pancreatitis on the association between type 2 diabetes and pancreatic cancer risk.
Diabetes Obes Metab 2012; 14(12):1123-8DO

Abstract

AIM

To examine the impact of diabetes duration, chronic pancreatitis and other factors on pancreatic cancer risk.

METHODS

This retrospective cohort study using the UK General Practice Research Database compared pancreatic cancer incidence and risk in patients with type 2 diabetes mellitus (T2DM) versus patients without diabetes. Multivariate Cox regression adjusting for age, sex, history of chronic pancreatitis, gallbladder disease, obesity, smoking and alcohol use and Charlson comorbidity index was used to estimate hazard ratio (HR) [95% confidence interval, CI]. Analyses were repeated using various time windows for diabetes duration.

RESULTS

A total of 1903 incident pancreatic cancers were identified, 436 in patients with T2DM (78.76 per 100 000 person-years [95% CI: 71.54, 86.51]) and 1467 in patients without diabetes (11.46 per 100 000 person-years [10.88, 12.06]). Pancreatic cancer risk was significant for T2DM (adjusted HR 1.80 [1.52, 2.14]), increasing age, history of chronic pancreatitis and tobacco use. For patients with chronic pancreatitis and T2DM, the adjusted HR was 12.12 [6.02, 24.40]. Incidence was highest in patients with ≥5 year duration of T2DM. In patient populations with duration of T2DM ranging from ≥1 to ≥5 years, adjusted HRs remained significant but point estimates attenuated slightly with longer duration of T2DM.

CONCLUSIONS

Patients with T2DM had an 80% increased risk of pancreatic cancer versus patients without diabetes. Patients with T2DM and chronic pancreatitis were 12 times more likely to develop pancreatic cancer.

Authors+Show Affiliations

Merck Sharp & Dohme Corp., Whitehouse Station, NJ, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22831166

Citation

Brodovicz, K G., et al. "Impact of Diabetes Duration and Chronic Pancreatitis On the Association Between Type 2 Diabetes and Pancreatic Cancer Risk." Diabetes, Obesity & Metabolism, vol. 14, no. 12, 2012, pp. 1123-8.
Brodovicz KG, Kou TD, Alexander CM, et al. Impact of diabetes duration and chronic pancreatitis on the association between type 2 diabetes and pancreatic cancer risk. Diabetes Obes Metab. 2012;14(12):1123-8.
Brodovicz, K. G., Kou, T. D., Alexander, C. M., O'Neill, E. A., Engel, S. S., Girman, C. J., & Goldstein, B. J. (2012). Impact of diabetes duration and chronic pancreatitis on the association between type 2 diabetes and pancreatic cancer risk. Diabetes, Obesity & Metabolism, 14(12), pp. 1123-8. doi:10.1111/j.1463-1326.2012.01667.x.
Brodovicz KG, et al. Impact of Diabetes Duration and Chronic Pancreatitis On the Association Between Type 2 Diabetes and Pancreatic Cancer Risk. Diabetes Obes Metab. 2012;14(12):1123-8. PubMed PMID: 22831166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of diabetes duration and chronic pancreatitis on the association between type 2 diabetes and pancreatic cancer risk. AU - Brodovicz,K G, AU - Kou,T D, AU - Alexander,C M, AU - O'Neill,E A, AU - Engel,S S, AU - Girman,C J, AU - Goldstein,B J, Y1 - 2012/08/14/ PY - 2012/03/16/received PY - 2012/05/11/revised PY - 2012/07/10/accepted PY - 2012/7/27/entrez PY - 2012/7/27/pubmed PY - 2015/2/24/medline KW - pancreatic cancer KW - reverse causality KW - type 2 diabetes SP - 1123 EP - 8 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 14 IS - 12 N2 - AIM: To examine the impact of diabetes duration, chronic pancreatitis and other factors on pancreatic cancer risk. METHODS: This retrospective cohort study using the UK General Practice Research Database compared pancreatic cancer incidence and risk in patients with type 2 diabetes mellitus (T2DM) versus patients without diabetes. Multivariate Cox regression adjusting for age, sex, history of chronic pancreatitis, gallbladder disease, obesity, smoking and alcohol use and Charlson comorbidity index was used to estimate hazard ratio (HR) [95% confidence interval, CI]. Analyses were repeated using various time windows for diabetes duration. RESULTS: A total of 1903 incident pancreatic cancers were identified, 436 in patients with T2DM (78.76 per 100 000 person-years [95% CI: 71.54, 86.51]) and 1467 in patients without diabetes (11.46 per 100 000 person-years [10.88, 12.06]). Pancreatic cancer risk was significant for T2DM (adjusted HR 1.80 [1.52, 2.14]), increasing age, history of chronic pancreatitis and tobacco use. For patients with chronic pancreatitis and T2DM, the adjusted HR was 12.12 [6.02, 24.40]. Incidence was highest in patients with ≥5 year duration of T2DM. In patient populations with duration of T2DM ranging from ≥1 to ≥5 years, adjusted HRs remained significant but point estimates attenuated slightly with longer duration of T2DM. CONCLUSIONS: Patients with T2DM had an 80% increased risk of pancreatic cancer versus patients without diabetes. Patients with T2DM and chronic pancreatitis were 12 times more likely to develop pancreatic cancer. SN - 1463-1326 UR - https://www.unboundmedicine.com/medline/citation/22831166/Impact_of_diabetes_duration_and_chronic_pancreatitis_on_the_association_between_type_2_diabetes_and_pancreatic_cancer_risk_ L2 - https://doi.org/10.1111/j.1463-1326.2012.01667.x DB - PRIME DP - Unbound Medicine ER -