Tags

Type your tag names separated by a space and hit enter

Generic health-related quality of life is significantly worse in varicose vein patients with lower limb symptoms independent of CEAP clinical grade.
Eur J Vasc Endovasc Surg 2012; 44(3):341-4EJ

Abstract

OBJECTIVES

To determine the relationship between lower limb symptoms and generic health-related quality of life (HRQL) in patients with varicose veins (VV).

METHODS

284 patients on the waiting list for VV treatment completed the Short Form-12 (SF12) and a questionnaire asking about the presence of lower limb symptoms commonly attributed to venous disease (pain or ache, itching, tingling, cramp, restless legs, a feeling of swelling, and heaviness).

RESULTS

Median age was 57 years (interquartile range 45-67); 100 (35%) were male, and 182 (64%) had CEAP clinical grade 2 or 3 disease. Jonckheere-Terpstra test for trend revealed that both physical (P < .0005) and mental (P = .001) HRQL worsened as the reported number of symptoms increased. Patients reporting tingling (P = .016, Mann-Whitney U test), cramp (P = .001), restless legs (P < .0005), swelling (P < .0005), and heaviness (P < .0005) had a significantly worse physical HRQL than those who did not. Mental HRQL was also significantly worse in patients with tingling (P = .010), cramp (P = .008), restless legs (P = .040), swelling (P = .001), and heaviness (P = .035). These significant relationships remained, and pain was also correlated with worse physical HRQL (P = .011), when linear regression was performed to control for CEAP clinical grade, age and sex.

CONCLUSIONS

Physical and mental HRQL is significantly worse in VV patients with lower limb symptoms irrespective of the clinical stage of disease. This observation confirms that VV are not primarily a cosmetic problem and that NHS rationing of treatment to those with CEAP C4-6 disease excludes many patients who would benefit from intervention in terms of HRQL. Generic HRQL instruments also allow comparison with interventions for other chronic conditions.

Authors+Show Affiliations

Birmingham University, Department of Vascular Surgery, Heart of England NHS Trust, Birmingham, UK. katydarvall@btinternet.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22831872

Citation

Darvall, K A L., et al. "Generic Health-related Quality of Life Is Significantly Worse in Varicose Vein Patients With Lower Limb Symptoms Independent of CEAP Clinical Grade." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 44, no. 3, 2012, pp. 341-4.
Darvall KA, Bate GR, Adam DJ, et al. Generic health-related quality of life is significantly worse in varicose vein patients with lower limb symptoms independent of CEAP clinical grade. Eur J Vasc Endovasc Surg. 2012;44(3):341-4.
Darvall, K. A., Bate, G. R., Adam, D. J., & Bradbury, A. W. (2012). Generic health-related quality of life is significantly worse in varicose vein patients with lower limb symptoms independent of CEAP clinical grade. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 44(3), pp. 341-4. doi:10.1016/j.ejvs.2012.06.022.
Darvall KA, et al. Generic Health-related Quality of Life Is Significantly Worse in Varicose Vein Patients With Lower Limb Symptoms Independent of CEAP Clinical Grade. Eur J Vasc Endovasc Surg. 2012;44(3):341-4. PubMed PMID: 22831872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Generic health-related quality of life is significantly worse in varicose vein patients with lower limb symptoms independent of CEAP clinical grade. AU - Darvall,K A L, AU - Bate,G R, AU - Adam,D J, AU - Bradbury,A W, Y1 - 2012/07/23/ PY - 2011/09/13/received PY - 2012/06/25/accepted PY - 2012/7/27/entrez PY - 2012/7/27/pubmed PY - 2012/11/3/medline SP - 341 EP - 4 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 44 IS - 3 N2 - OBJECTIVES: To determine the relationship between lower limb symptoms and generic health-related quality of life (HRQL) in patients with varicose veins (VV). METHODS: 284 patients on the waiting list for VV treatment completed the Short Form-12 (SF12) and a questionnaire asking about the presence of lower limb symptoms commonly attributed to venous disease (pain or ache, itching, tingling, cramp, restless legs, a feeling of swelling, and heaviness). RESULTS: Median age was 57 years (interquartile range 45-67); 100 (35%) were male, and 182 (64%) had CEAP clinical grade 2 or 3 disease. Jonckheere-Terpstra test for trend revealed that both physical (P < .0005) and mental (P = .001) HRQL worsened as the reported number of symptoms increased. Patients reporting tingling (P = .016, Mann-Whitney U test), cramp (P = .001), restless legs (P < .0005), swelling (P < .0005), and heaviness (P < .0005) had a significantly worse physical HRQL than those who did not. Mental HRQL was also significantly worse in patients with tingling (P = .010), cramp (P = .008), restless legs (P = .040), swelling (P = .001), and heaviness (P = .035). These significant relationships remained, and pain was also correlated with worse physical HRQL (P = .011), when linear regression was performed to control for CEAP clinical grade, age and sex. CONCLUSIONS: Physical and mental HRQL is significantly worse in VV patients with lower limb symptoms irrespective of the clinical stage of disease. This observation confirms that VV are not primarily a cosmetic problem and that NHS rationing of treatment to those with CEAP C4-6 disease excludes many patients who would benefit from intervention in terms of HRQL. Generic HRQL instruments also allow comparison with interventions for other chronic conditions. SN - 1532-2165 UR - https://www.unboundmedicine.com/medline/citation/22831872/Generic_health_related_quality_of_life_is_significantly_worse_in_varicose_vein_patients_with_lower_limb_symptoms_independent_of_CEAP_clinical_grade_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-5884(12)00434-0 DB - PRIME DP - Unbound Medicine ER -