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Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes.
Nutr Metab Cardiovasc Dis. 2013 Sep; 23(9):822-8.NM

Abstract

BACKGROUND AND AIM

A high intake of dairy has been linked to lower risk of type 2 diabetes (T2D). The relationship between dairy intake and glucose metabolism is still not well understood. The aim of this study was to investigate the relation between the intake of total dairy and dairy subgroups and T2D and measures of glucose metabolism.

METHODS AND RESULTS

A total of 5953 Danish men and women aged 30-60 years without baseline diabetes or cardiovascular diseases were included in this prospective analysis. The dairy intake at baseline was categorised into low-fat dairy, full-fat dairy, milk and milk products, cheese and fermented dairy. Fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), HbA1c, insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-B) were considered at 5-year follow-up. In the maximally-adjusted model (demographics, lifestyle factors, dietary factors and waist), cheese intake was inversely associated with 2hPG (β = -0.048, 95% CI -0.095; -0.001). Fermented dairy intake was inversely associated with FPG (β = -0.028, 95% CI -0.048; -0.008) and HbA1c (β = -0.016, 95% CI -0.030; -0.001). Total dairy intake and the dairy subgroups were not related to HOMA-IR and HOMA-B in the maximally-adjusted model. Furthermore, there was no significant association between intake of total dairy or any of the dairy subgroups and incidence of T2D.

CONCLUSION

Our data suggest a modest beneficial effect of cheese and fermented dairy on glucose regulation measures; however, this did not translate into a significant association with incident T2D.

Authors+Show Affiliations

Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark; Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22831954

Citation

Struijk, E A., et al. "Dairy Product Intake in Relation to Glucose Regulation Indices and Risk of Type 2 Diabetes." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 23, no. 9, 2013, pp. 822-8.
Struijk EA, Heraclides A, Witte DR, et al. Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes. Nutr Metab Cardiovasc Dis. 2013;23(9):822-8.
Struijk, E. A., Heraclides, A., Witte, D. R., Soedamah-Muthu, S. S., Geleijnse, J. M., Toft, U., & Lau, C. J. (2013). Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 23(9), 822-8. https://doi.org/10.1016/j.numecd.2012.05.011
Struijk EA, et al. Dairy Product Intake in Relation to Glucose Regulation Indices and Risk of Type 2 Diabetes. Nutr Metab Cardiovasc Dis. 2013;23(9):822-8. PubMed PMID: 22831954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes. AU - Struijk,E A, AU - Heraclides,A, AU - Witte,D R, AU - Soedamah-Muthu,S S, AU - Geleijnse,J M, AU - Toft,U, AU - Lau,C J, Y1 - 2012/07/23/ PY - 2011/05/19/received PY - 2012/05/30/revised PY - 2012/05/31/accepted PY - 2012/7/27/entrez PY - 2012/7/27/pubmed PY - 2014/4/29/medline KW - 2-h plasma glucose KW - 2hPG KW - Beta-cell function KW - Blood glucose KW - Dairy products KW - FFQ KW - FPG KW - HOMA2-B KW - HOMA2-IR KW - Insulin resistance KW - OGTT KW - T2D KW - Type 2 diabetes KW - beta-cell function KW - fasting plasma glucose KW - food frequency questionnaire KW - insulin resistance KW - oral glucose tolerance test KW - type 2 diabetes SP - 822 EP - 8 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 23 IS - 9 N2 - BACKGROUND AND AIM: A high intake of dairy has been linked to lower risk of type 2 diabetes (T2D). The relationship between dairy intake and glucose metabolism is still not well understood. The aim of this study was to investigate the relation between the intake of total dairy and dairy subgroups and T2D and measures of glucose metabolism. METHODS AND RESULTS: A total of 5953 Danish men and women aged 30-60 years without baseline diabetes or cardiovascular diseases were included in this prospective analysis. The dairy intake at baseline was categorised into low-fat dairy, full-fat dairy, milk and milk products, cheese and fermented dairy. Fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), HbA1c, insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-B) were considered at 5-year follow-up. In the maximally-adjusted model (demographics, lifestyle factors, dietary factors and waist), cheese intake was inversely associated with 2hPG (β = -0.048, 95% CI -0.095; -0.001). Fermented dairy intake was inversely associated with FPG (β = -0.028, 95% CI -0.048; -0.008) and HbA1c (β = -0.016, 95% CI -0.030; -0.001). Total dairy intake and the dairy subgroups were not related to HOMA-IR and HOMA-B in the maximally-adjusted model. Furthermore, there was no significant association between intake of total dairy or any of the dairy subgroups and incidence of T2D. CONCLUSION: Our data suggest a modest beneficial effect of cheese and fermented dairy on glucose regulation measures; however, this did not translate into a significant association with incident T2D. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/22831954/Dairy_product_intake_in_relation_to_glucose_regulation_indices_and_risk_of_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(12)00153-6 DB - PRIME DP - Unbound Medicine ER -