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The association between cognitive impairment and neuropsychiatric symptoms in patients with Parkinson's disease dementia.
Int Psychogeriatr. 2012 Dec; 24(12):1980-7.IP

Abstract

BACKGROUND

Neuropsychiatric symptoms (NPS) are common in patients with dementia associated with Parkinson's disease (PDD). The relationship between cognition and NPS in PDD has not been well studied.

METHODS

Patients diagnosed with PDD were assessed for cognitive function and NPS. The instruments used were the Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), and semantic verbal fluency according to the recommendation of the Movement Disorder Society Task Force.

RESULTS

We evaluated 127 PDD patients (76 males/51 females; mean age 77 ± 6.3 years). Their mean MMSE score was 17 ± 6.5 and the mean NPI score was 19 ± 20.4. The most prevalent NPI items were anxiety (57.5%), sleep problems (53.5%), and apathy (52.0%). Principal component factor analysis revealed that 12 items formed three factors, namely "mood and psychosis" (delusion, hallucination, agitation, depression, anxiety, apathy, and irritability), "vegetative" (sleep and appetite problems), and "frontal" (euphoria, disinhibition, and aberrant motor behavior). Symptoms of hallucination were significantly associated with MMSE score, even after controlling for the confounding variables.

CONCLUSION

NPS are common and diverse among patients with PDD. Three specific subgroups of NPS were identified. Hallucination was significantly correlated with cognitive impairment, and could be a predictor of cognition in PDD patients.

Authors+Show Affiliations

Department of Neurology, Taichung Veterans General Hospital, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22835209

Citation

Lee, Wei-Ju, et al. "The Association Between Cognitive Impairment and Neuropsychiatric Symptoms in Patients With Parkinson's Disease Dementia." International Psychogeriatrics, vol. 24, no. 12, 2012, pp. 1980-7.
Lee WJ, Tsai CF, Gauthier S, et al. The association between cognitive impairment and neuropsychiatric symptoms in patients with Parkinson's disease dementia. Int Psychogeriatr. 2012;24(12):1980-7.
Lee, W. J., Tsai, C. F., Gauthier, S., Wang, S. J., & Fuh, J. L. (2012). The association between cognitive impairment and neuropsychiatric symptoms in patients with Parkinson's disease dementia. International Psychogeriatrics, 24(12), 1980-7. https://doi.org/10.1017/S1041610212001317
Lee WJ, et al. The Association Between Cognitive Impairment and Neuropsychiatric Symptoms in Patients With Parkinson's Disease Dementia. Int Psychogeriatr. 2012;24(12):1980-7. PubMed PMID: 22835209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between cognitive impairment and neuropsychiatric symptoms in patients with Parkinson's disease dementia. AU - Lee,Wei-Ju, AU - Tsai,Chia-Fen, AU - Gauthier,Serge, AU - Wang,Shuu-Jiun, AU - Fuh,Jong-Ling, Y1 - 2012/07/27/ PY - 2012/7/28/entrez PY - 2012/7/28/pubmed PY - 2013/5/3/medline SP - 1980 EP - 7 JF - International psychogeriatrics JO - Int Psychogeriatr VL - 24 IS - 12 N2 - BACKGROUND: Neuropsychiatric symptoms (NPS) are common in patients with dementia associated with Parkinson's disease (PDD). The relationship between cognition and NPS in PDD has not been well studied. METHODS: Patients diagnosed with PDD were assessed for cognitive function and NPS. The instruments used were the Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), and semantic verbal fluency according to the recommendation of the Movement Disorder Society Task Force. RESULTS: We evaluated 127 PDD patients (76 males/51 females; mean age 77 ± 6.3 years). Their mean MMSE score was 17 ± 6.5 and the mean NPI score was 19 ± 20.4. The most prevalent NPI items were anxiety (57.5%), sleep problems (53.5%), and apathy (52.0%). Principal component factor analysis revealed that 12 items formed three factors, namely "mood and psychosis" (delusion, hallucination, agitation, depression, anxiety, apathy, and irritability), "vegetative" (sleep and appetite problems), and "frontal" (euphoria, disinhibition, and aberrant motor behavior). Symptoms of hallucination were significantly associated with MMSE score, even after controlling for the confounding variables. CONCLUSION: NPS are common and diverse among patients with PDD. Three specific subgroups of NPS were identified. Hallucination was significantly correlated with cognitive impairment, and could be a predictor of cognition in PDD patients. SN - 1741-203X UR - https://www.unboundmedicine.com/medline/citation/22835209/The_association_between_cognitive_impairment_and_neuropsychiatric_symptoms_in_patients_with_Parkinson's_disease_dementia_ L2 - https://www.cambridge.org/core/product/identifier/S1041610212001317/type/journal_article DB - PRIME DP - Unbound Medicine ER -