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The changing epidemiology of hepatitis A in Arizona following intensive immunization programs (1988-2007).
Vaccine. 2012 Sep 14; 30(42):6103-10.V

Abstract

INTRODUCTION

Arizona had the highest hepatitis A incidence of any U.S. state during 1987-1997. In 1995, the first hepatitis A vaccines became available in the U.S. A series of hepatitis A vaccination policies and recommendations were implemented in 1996-2006. Our objective was to examine the shifting epidemiologic patterns in hepatitis A in Arizona from 1988 to 2007.

METHODS

Passive surveillance reports to the Arizona Department of Health Services were used to compare hepatitis A rates by age, race/ethnicity and geographic area, before and after widespread vaccination. Reported risk factors and possible sources of infection were compared for two time periods. Age-adjusted incidence during three periods was mapped.

RESULTS

Overall hepatitis A incidence in Arizona fell from 58 cases per 100,000 in 1988 to 2 per 100,000 in 2007. The proportion of reported cases among children dropped from 62% in 1994-1995 to 32% in 2006-2007. Racial/ethnic disparities between American Indians and non-Hispanic White populations have been eliminated. The geographic distribution of cases within the state has shifted. Earlier cases were likely to report contact with another hepatitis A case or childcare facilities, while later cases indicated recent international travel.

CONCLUSION

A major shift in the overall burden of hepatitis A and hepatitis A transmission has occurred in Arizona since the widespread implementation of immunization policies and the concomitant rise in vaccination rates in the state. Current transmission has shifted to older age groups and disparities by race/ethnicity are now highest in Hispanic populations. Future strategies to further reduce hepatitis A transmission may require broadening recommendations to include general adult populations without previous vaccination history.

Authors+Show Affiliations

Office of Infectious Disease Services, Arizona Department of Health Services, Phoenix, AZ, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22835739

Citation

Erhart, Laura M., and Kacey C. Ernst. "The Changing Epidemiology of Hepatitis a in Arizona Following Intensive Immunization Programs (1988-2007)." Vaccine, vol. 30, no. 42, 2012, pp. 6103-10.
Erhart LM, Ernst KC. The changing epidemiology of hepatitis A in Arizona following intensive immunization programs (1988-2007). Vaccine. 2012;30(42):6103-10.
Erhart, L. M., & Ernst, K. C. (2012). The changing epidemiology of hepatitis A in Arizona following intensive immunization programs (1988-2007). Vaccine, 30(42), 6103-10. https://doi.org/10.1016/j.vaccine.2012.07.029
Erhart LM, Ernst KC. The Changing Epidemiology of Hepatitis a in Arizona Following Intensive Immunization Programs (1988-2007). Vaccine. 2012 Sep 14;30(42):6103-10. PubMed PMID: 22835739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The changing epidemiology of hepatitis A in Arizona following intensive immunization programs (1988-2007). AU - Erhart,Laura M, AU - Ernst,Kacey C, Y1 - 2012/07/24/ PY - 2012/05/08/received PY - 2012/07/09/revised PY - 2012/07/10/accepted PY - 2012/7/28/entrez PY - 2012/7/28/pubmed PY - 2013/1/8/medline SP - 6103 EP - 10 JF - Vaccine JO - Vaccine VL - 30 IS - 42 N2 - INTRODUCTION: Arizona had the highest hepatitis A incidence of any U.S. state during 1987-1997. In 1995, the first hepatitis A vaccines became available in the U.S. A series of hepatitis A vaccination policies and recommendations were implemented in 1996-2006. Our objective was to examine the shifting epidemiologic patterns in hepatitis A in Arizona from 1988 to 2007. METHODS: Passive surveillance reports to the Arizona Department of Health Services were used to compare hepatitis A rates by age, race/ethnicity and geographic area, before and after widespread vaccination. Reported risk factors and possible sources of infection were compared for two time periods. Age-adjusted incidence during three periods was mapped. RESULTS: Overall hepatitis A incidence in Arizona fell from 58 cases per 100,000 in 1988 to 2 per 100,000 in 2007. The proportion of reported cases among children dropped from 62% in 1994-1995 to 32% in 2006-2007. Racial/ethnic disparities between American Indians and non-Hispanic White populations have been eliminated. The geographic distribution of cases within the state has shifted. Earlier cases were likely to report contact with another hepatitis A case or childcare facilities, while later cases indicated recent international travel. CONCLUSION: A major shift in the overall burden of hepatitis A and hepatitis A transmission has occurred in Arizona since the widespread implementation of immunization policies and the concomitant rise in vaccination rates in the state. Current transmission has shifted to older age groups and disparities by race/ethnicity are now highest in Hispanic populations. Future strategies to further reduce hepatitis A transmission may require broadening recommendations to include general adult populations without previous vaccination history. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/22835739/The_changing_epidemiology_of_hepatitis_A_in_Arizona_following_intensive_immunization_programs__1988_2007__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(12)01031-6 DB - PRIME DP - Unbound Medicine ER -