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Local and circulating levels of adipocytokines in obese and normal weight individuals with chronic periodontitis.
J Periodontol. 2013 May; 84(5):624-33.JP

Abstract

BACKGROUND

The aim of this study is to evaluate the local and circulating levels of adipocytokines (resistin, adiponectin, leptin, tumor necrosis factor [TNF]-α, and interleukin [IL]-6) in individuals who are obese and individuals who are normal weight (NW) with chronic periodontitis (CP).

METHODS

Periodontal and anthropometric examinations were performed. Based on these measurements, the individuals were divided into one of the following groups: NW non-periodontitis (NP) (NWNP; n = 20); NWCP (n = 20); obese NP (ONP; n = 18); and obese CP (OCP; n = 20). The levels of adipocytokines were evaluated in the serum and gingival crevicular fluid of shallow and deep sites by enzyme-linked immunosorbent assay.

RESULTS

In serum, resistin levels were higher whereas adiponectin levels were lower in periodontitis than in NP groups (P <0.05). The NWNP group presented the lowest serum leptin levels (P <0.05). The ONP and OCP groups demonstrated higher TNF-α levels in periodontal sites than the NWNP and NWCP groups (P <0.05). Serum levels of IL-6 (P = 0.04) and leptin (P = 0.01) were correlated with the OCP group, with odds ratios of 0.99 (95% confidence interval [CI]: -0.01 to -0.00) and 0.99 (95% CI: -0.00 to -0.00), respectively.

CONCLUSIONS

Periodontitis mainly influenced the circulating levels of resistin and adiponectin, whereas both obesity and periodontitis affected the circulating levels of leptin in favor of proinflammation. In addition, obesity upregulated the local levels of TNF-α.

Authors+Show Affiliations

Department of Periodontology, Guarulhos University, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22839694

Citation

Zimmermann, Glaucia Santos, et al. "Local and Circulating Levels of Adipocytokines in Obese and Normal Weight Individuals With Chronic Periodontitis." Journal of Periodontology, vol. 84, no. 5, 2013, pp. 624-33.
Zimmermann GS, Bastos MF, Dias Gonçalves TE, et al. Local and circulating levels of adipocytokines in obese and normal weight individuals with chronic periodontitis. J Periodontol. 2013;84(5):624-33.
Zimmermann, G. S., Bastos, M. F., Dias Gonçalves, T. E., Chambrone, L., & Duarte, P. M. (2013). Local and circulating levels of adipocytokines in obese and normal weight individuals with chronic periodontitis. Journal of Periodontology, 84(5), 624-33. https://doi.org/10.1902/jop.2012.120254
Zimmermann GS, et al. Local and Circulating Levels of Adipocytokines in Obese and Normal Weight Individuals With Chronic Periodontitis. J Periodontol. 2013;84(5):624-33. PubMed PMID: 22839694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local and circulating levels of adipocytokines in obese and normal weight individuals with chronic periodontitis. AU - Zimmermann,Glaucia Santos, AU - Bastos,Marta Ferreira, AU - Dias Gonçalves,Tiago Eduardo, AU - Chambrone,Leandro, AU - Duarte,Poliana Mendes, Y1 - 2012/07/27/ PY - 2012/7/31/entrez PY - 2012/7/31/pubmed PY - 2013/11/12/medline SP - 624 EP - 33 JF - Journal of periodontology JO - J. Periodontol. VL - 84 IS - 5 N2 - BACKGROUND: The aim of this study is to evaluate the local and circulating levels of adipocytokines (resistin, adiponectin, leptin, tumor necrosis factor [TNF]-α, and interleukin [IL]-6) in individuals who are obese and individuals who are normal weight (NW) with chronic periodontitis (CP). METHODS: Periodontal and anthropometric examinations were performed. Based on these measurements, the individuals were divided into one of the following groups: NW non-periodontitis (NP) (NWNP; n = 20); NWCP (n = 20); obese NP (ONP; n = 18); and obese CP (OCP; n = 20). The levels of adipocytokines were evaluated in the serum and gingival crevicular fluid of shallow and deep sites by enzyme-linked immunosorbent assay. RESULTS: In serum, resistin levels were higher whereas adiponectin levels were lower in periodontitis than in NP groups (P <0.05). The NWNP group presented the lowest serum leptin levels (P <0.05). The ONP and OCP groups demonstrated higher TNF-α levels in periodontal sites than the NWNP and NWCP groups (P <0.05). Serum levels of IL-6 (P = 0.04) and leptin (P = 0.01) were correlated with the OCP group, with odds ratios of 0.99 (95% confidence interval [CI]: -0.01 to -0.00) and 0.99 (95% CI: -0.00 to -0.00), respectively. CONCLUSIONS: Periodontitis mainly influenced the circulating levels of resistin and adiponectin, whereas both obesity and periodontitis affected the circulating levels of leptin in favor of proinflammation. In addition, obesity upregulated the local levels of TNF-α. SN - 1943-3670 UR - https://www.unboundmedicine.com/medline/citation/22839694/Local_and_circulating_levels_of_adipocytokines_in_obese_and_normal_weight_individuals_with_chronic_periodontitis_ L2 - https://doi.org/10.1902/jop.2012.120254 DB - PRIME DP - Unbound Medicine ER -