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A comparison of bone mineral density in normal weight and obese adolescents with polycystic ovary syndrome.
J Pediatr Adolesc Gynecol. 2012 Aug; 25(4):248-53.JP

Abstract

STUDY OBJECTIVE

To evaluate whether there are any differences in bone mineral density (BMD) between normal weight and obese adolescents suffering from polycystic ovary syndrome (PCOS) with oligo/amenorrhea.

DESIGN

Prospective cohort study.

SETTING

Adolescent gynecology clinic in a general service hospital.

PARTICIPANTS

Subjects consisted of adolescents between 16 to 18 years of age presenting with oligo/ amenorrhea with ultrasound morphology of polycystic ovaries ± evidence of hyperandrogenism over 24 months. Controls consisted of consecutive eumenorrheic patients within the same age group.

INTERVENTIONS

All underwent full hormonal profile assessment, and dual energy X-ray absorptiometry and peripheral quantitative computed tomography scans.

MAIN OUTCOME MEASURES

Areal and volumetric BMD parameters.

RESULTS

Of 37 adolescents with PCOS, 12 (32%) were obese with BMI ≥25, of which 9/12 (75%) were hyperandrogenic. The control group consisted of 40 normal weight eumenorrheic girls. The PCOS group overall had lower lumbar spine BMD values as compared to the controls (0.91 vs 0.97 g/ cm(2), P = 0.033). The normal weight PCOS group had lower BMD at the spine (0.90 vs 0.97 g/ cm(2), P = 0.027), trochanter (0.66 vs 0.71 g/ cm(2), P = 0.039) as well as volumetric distal tibial core sites (268 vs 296 mg/ cm(3)) as compared to eumenorrheic controls, but there were no significant BMD differences between the obese PCOS group and the eumenorrheic controls.

CONCLUSIONS

Normal weight PCOS adolescents with oligo/amenorrhea have marginally lower BMD values than controls, but obese PCOS adolescents have BMD values compatible with eumenorrheic adolescents.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, United Christian Hospital, Kowloon, Hong Kong SAR. towkw@ha.org.hkNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22840935

Citation

To, William W K., and Margaret W N. Wong. "A Comparison of Bone Mineral Density in Normal Weight and Obese Adolescents With Polycystic Ovary Syndrome." Journal of Pediatric and Adolescent Gynecology, vol. 25, no. 4, 2012, pp. 248-53.
To WW, Wong MW. A comparison of bone mineral density in normal weight and obese adolescents with polycystic ovary syndrome. J Pediatr Adolesc Gynecol. 2012;25(4):248-53.
To, W. W., & Wong, M. W. (2012). A comparison of bone mineral density in normal weight and obese adolescents with polycystic ovary syndrome. Journal of Pediatric and Adolescent Gynecology, 25(4), 248-53. https://doi.org/10.1016/j.jpag.2011.12.073
To WW, Wong MW. A Comparison of Bone Mineral Density in Normal Weight and Obese Adolescents With Polycystic Ovary Syndrome. J Pediatr Adolesc Gynecol. 2012;25(4):248-53. PubMed PMID: 22840935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of bone mineral density in normal weight and obese adolescents with polycystic ovary syndrome. AU - To,William W K, AU - Wong,Margaret W N, PY - 2011/08/24/received PY - 2011/12/20/revised PY - 2011/12/27/accepted PY - 2012/7/31/entrez PY - 2012/7/31/pubmed PY - 2013/2/7/medline SP - 248 EP - 53 JF - Journal of pediatric and adolescent gynecology JO - J Pediatr Adolesc Gynecol VL - 25 IS - 4 N2 - STUDY OBJECTIVE: To evaluate whether there are any differences in bone mineral density (BMD) between normal weight and obese adolescents suffering from polycystic ovary syndrome (PCOS) with oligo/amenorrhea. DESIGN: Prospective cohort study. SETTING: Adolescent gynecology clinic in a general service hospital. PARTICIPANTS: Subjects consisted of adolescents between 16 to 18 years of age presenting with oligo/ amenorrhea with ultrasound morphology of polycystic ovaries ± evidence of hyperandrogenism over 24 months. Controls consisted of consecutive eumenorrheic patients within the same age group. INTERVENTIONS: All underwent full hormonal profile assessment, and dual energy X-ray absorptiometry and peripheral quantitative computed tomography scans. MAIN OUTCOME MEASURES: Areal and volumetric BMD parameters. RESULTS: Of 37 adolescents with PCOS, 12 (32%) were obese with BMI ≥25, of which 9/12 (75%) were hyperandrogenic. The control group consisted of 40 normal weight eumenorrheic girls. The PCOS group overall had lower lumbar spine BMD values as compared to the controls (0.91 vs 0.97 g/ cm(2), P = 0.033). The normal weight PCOS group had lower BMD at the spine (0.90 vs 0.97 g/ cm(2), P = 0.027), trochanter (0.66 vs 0.71 g/ cm(2), P = 0.039) as well as volumetric distal tibial core sites (268 vs 296 mg/ cm(3)) as compared to eumenorrheic controls, but there were no significant BMD differences between the obese PCOS group and the eumenorrheic controls. CONCLUSIONS: Normal weight PCOS adolescents with oligo/amenorrhea have marginally lower BMD values than controls, but obese PCOS adolescents have BMD values compatible with eumenorrheic adolescents. SN - 1873-4332 UR - https://www.unboundmedicine.com/medline/citation/22840935/A_comparison_of_bone_mineral_density_in_normal_weight_and_obese_adolescents_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1083-3188(12)00004-6 DB - PRIME DP - Unbound Medicine ER -