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Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase.
Neurotoxicology. 2012 Oct; 33(5):1248-53.N

Abstract

Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.

Authors+Show Affiliations

School of Life Science, Beijing Institute of Technology, Beijing 100081, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22841599

Citation

Che, Baoquan, et al. "Distribution and Accumulation of Caffeine in Rat Tissues and Its Inhibition On Semicarbazide-sensitive Amine Oxidase." Neurotoxicology, vol. 33, no. 5, 2012, pp. 1248-53.
Che B, Wang L, Zhang Z, et al. Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase. Neurotoxicology. 2012;33(5):1248-53.
Che, B., Wang, L., Zhang, Z., Zhang, Y., & Deng, Y. (2012). Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase. Neurotoxicology, 33(5), 1248-53. https://doi.org/10.1016/j.neuro.2012.07.004
Che B, et al. Distribution and Accumulation of Caffeine in Rat Tissues and Its Inhibition On Semicarbazide-sensitive Amine Oxidase. Neurotoxicology. 2012;33(5):1248-53. PubMed PMID: 22841599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase. AU - Che,Baoquan, AU - Wang,Lin, AU - Zhang,Zhe, AU - Zhang,Yongqian, AU - Deng,Yulin, Y1 - 2012/07/25/ PY - 2012/03/05/received PY - 2012/07/05/revised PY - 2012/07/18/accepted PY - 2012/7/31/entrez PY - 2012/7/31/pubmed PY - 2013/3/22/medline SP - 1248 EP - 53 JF - Neurotoxicology JO - Neurotoxicology VL - 33 IS - 5 N2 - Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/22841599/Distribution_and_accumulation_of_caffeine_in_rat_tissues_and_its_inhibition_on_semicarbazide_sensitive_amine_oxidase_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(12)00190-8 DB - PRIME DP - Unbound Medicine ER -