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Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies.

Abstract

The shared risk factor profile between cardiovascular diseases and Alzheimer's disease (AD), observations on vascular pathology in AD, and altered cerebral blood flow in AD brains have led to the suggestion that AD might be a vascular disorder with neurodegenerative consequences. Targeting vascular and metabolic risk factors could be an effective way to prevent AD. Higher body mass index, elevated blood pressure, serum cholesterol concentrations, and impaired glucose regulation have been associated with increased risk of AD. Interestingly, the associations between these factors measured at mid-life are stronger, or even opposite, than with the risk factors measured at late-life. This may reflect true differences in the association (i.e., mid-life risk factors being a better measure of vascular load during adulthood), reverse causality, or bias. The vascular risk factors can directly increase the susceptibility to AD, or the effect can be mediated via cardio- and cerebrovascular diseases.

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  • Authors+Show Affiliations

    ,

    Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland. anna-maija.tolppanen@uef.fi

    , ,

    Source

    MeSH

    Alzheimer Disease
    Animals
    Cardiovascular Diseases
    Cerebrovascular Disorders
    Humans
    Middle Aged
    Obesity
    Risk Factors
    Risk Reduction Behavior
    Vascular Diseases

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    22842867

    Citation

    Tolppanen, Anna-Maija, et al. "Midlife Vascular Risk Factors and Alzheimer's Disease: Evidence From Epidemiological Studies." Journal of Alzheimer's Disease : JAD, vol. 32, no. 3, 2012, pp. 531-40.
    Tolppanen AM, Solomon A, Soininen H, et al. Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies. J Alzheimers Dis. 2012;32(3):531-40.
    Tolppanen, A. M., Solomon, A., Soininen, H., & Kivipelto, M. (2012). Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies. Journal of Alzheimer's Disease : JAD, 32(3), pp. 531-40. doi:10.3233/JAD-2012-120802.
    Tolppanen AM, et al. Midlife Vascular Risk Factors and Alzheimer's Disease: Evidence From Epidemiological Studies. J Alzheimers Dis. 2012;32(3):531-40. PubMed PMID: 22842867.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies. AU - Tolppanen,Anna-Maija, AU - Solomon,Alina, AU - Soininen,Hilkka, AU - Kivipelto,Miia, PY - 2012/7/31/entrez PY - 2012/7/31/pubmed PY - 2013/9/5/medline SP - 531 EP - 40 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 32 IS - 3 N2 - The shared risk factor profile between cardiovascular diseases and Alzheimer's disease (AD), observations on vascular pathology in AD, and altered cerebral blood flow in AD brains have led to the suggestion that AD might be a vascular disorder with neurodegenerative consequences. Targeting vascular and metabolic risk factors could be an effective way to prevent AD. Higher body mass index, elevated blood pressure, serum cholesterol concentrations, and impaired glucose regulation have been associated with increased risk of AD. Interestingly, the associations between these factors measured at mid-life are stronger, or even opposite, than with the risk factors measured at late-life. This may reflect true differences in the association (i.e., mid-life risk factors being a better measure of vascular load during adulthood), reverse causality, or bias. The vascular risk factors can directly increase the susceptibility to AD, or the effect can be mediated via cardio- and cerebrovascular diseases. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/22842867/Midlife_vascular_risk_factors_and_Alzheimer's_disease:_evidence_from_epidemiological_studies_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2012-120802 DB - PRIME DP - Unbound Medicine ER -