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Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies.
J Zhejiang Univ Sci B 2012; 13(8):652-62JZ

Abstract

OBJECTIVE

To determine the association between tea consumption and the risk of stroke.

METHODS

We searched the PubMed database from January 1966 to March 2012 and reviewed reference lists of retrieved articles to identify relevant studies. Studies were included if they reported relative risks (RRs) and corresponding 95% confidence intervals (CIs) of stroke with respect to three or more categories of tea consumption. A random-effects model was used to combine the study-specific risk estimates.

RESULTS

Fourteen studies, consisting of 513,804 participants with a median follow-up of 11.5 years, were included in this meta-analysis. We observed a modest but statistically significant inverse association between tea consumption and risk of stroke. An increase of three cups/d in tea consumption was associated with a 13% decreased risk of stroke (RR 0.87; 95% CI, 0.81-0.94). The decreased risk of stroke with tea consumption was consistent among most subgroups. Based on the three studies that provided results for stroke subtypes, tea consumption was also inversely associated with the risk of ischemic stroke (RR 0.76; 95% CI, 0.69-0.84), but not cerebral hemorrhage (RR 0.96; 95% CI, 0.82-1.11) or subarachnoid hemorrhage (RR 0.81; 95% CI, 0.57-1.16).

CONCLUSIONS

Tea consumption is associated with a decreased risk of stroke, particularly ischemic stroke. More well-designed, rigorously conducted studies are needed in order to make confident conclusions about the association between tea consumption and stroke subtypes.

Authors+Show Affiliations

Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22843186

Citation

Shen, Li, et al. "Tea Consumption and Risk of Stroke: a Dose-response Meta-analysis of Prospective Studies." Journal of Zhejiang University. Science. B, vol. 13, no. 8, 2012, pp. 652-62.
Shen L, Song LG, Ma H, et al. Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies. J Zhejiang Univ Sci B. 2012;13(8):652-62.
Shen, L., Song, L. G., Ma, H., Jin, C. N., Wang, J. A., & Xiang, M. X. (2012). Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies. Journal of Zhejiang University. Science. B, 13(8), pp. 652-62. doi:10.1631/jzus.B1201001.
Shen L, et al. Tea Consumption and Risk of Stroke: a Dose-response Meta-analysis of Prospective Studies. J Zhejiang Univ Sci B. 2012;13(8):652-62. PubMed PMID: 22843186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies. AU - Shen,Li, AU - Song,Liu-guang, AU - Ma,Hong, AU - Jin,Chun-na, AU - Wang,Jian-an, AU - Xiang,Mei-xiang, PY - 2012/7/31/entrez PY - 2012/7/31/pubmed PY - 2012/12/22/medline SP - 652 EP - 62 JF - Journal of Zhejiang University. Science. B JO - J Zhejiang Univ Sci B VL - 13 IS - 8 N2 - OBJECTIVE: To determine the association between tea consumption and the risk of stroke. METHODS: We searched the PubMed database from January 1966 to March 2012 and reviewed reference lists of retrieved articles to identify relevant studies. Studies were included if they reported relative risks (RRs) and corresponding 95% confidence intervals (CIs) of stroke with respect to three or more categories of tea consumption. A random-effects model was used to combine the study-specific risk estimates. RESULTS: Fourteen studies, consisting of 513,804 participants with a median follow-up of 11.5 years, were included in this meta-analysis. We observed a modest but statistically significant inverse association between tea consumption and risk of stroke. An increase of three cups/d in tea consumption was associated with a 13% decreased risk of stroke (RR 0.87; 95% CI, 0.81-0.94). The decreased risk of stroke with tea consumption was consistent among most subgroups. Based on the three studies that provided results for stroke subtypes, tea consumption was also inversely associated with the risk of ischemic stroke (RR 0.76; 95% CI, 0.69-0.84), but not cerebral hemorrhage (RR 0.96; 95% CI, 0.82-1.11) or subarachnoid hemorrhage (RR 0.81; 95% CI, 0.57-1.16). CONCLUSIONS: Tea consumption is associated with a decreased risk of stroke, particularly ischemic stroke. More well-designed, rigorously conducted studies are needed in order to make confident conclusions about the association between tea consumption and stroke subtypes. SN - 1862-1783 UR - https://www.unboundmedicine.com/medline/citation/22843186/Tea_consumption_and_risk_of_stroke:_a_dose_response_meta_analysis_of_prospective_studies_ L2 - http://www.jzus.zju.edu.cn/article.php?doi=10.1631/jzus.B1201001 DB - PRIME DP - Unbound Medicine ER -