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Genetic testing by cancer site: ovary.
Cancer J 2012 Jul-Aug; 18(4):320-7CJ

Abstract

Approximately 1 in every 4 to 5 women with a diagnosis of ovarian cancer has a hereditary gene mutation that is responsible for the development of her cancer. Identifying women at increased risk of developing ovarian cancer due to a hereditary cancer syndrome can allow for early detection or prevention of not only ovarian cancer, but also other cancers, depending on the causative gene. This review focuses on 3 of the most common hereditary ovarian cancer syndromes, hereditary breast and ovarian cancer syndrome (the BRCA1 and BRCA2 genes), Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer syndrome), and Peutz-Jeghers syndrome, including key features, genetics, and management of these syndromes. In addition, newly discovered genes (eg, RAD51C and RAD51D) linked to ovarian cancer are discussed.

Authors+Show Affiliations

NorthShore University HealthSystem, Center for Medical Genetics, Evanston, IL 60201, USA. sweissman@northshore.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22846732

Citation

Weissman, Scott M., et al. "Genetic Testing By Cancer Site: Ovary." Cancer Journal (Sudbury, Mass.), vol. 18, no. 4, 2012, pp. 320-7.
Weissman SM, Weiss SM, Newlin AC. Genetic testing by cancer site: ovary. Cancer J. 2012;18(4):320-7.
Weissman, S. M., Weiss, S. M., & Newlin, A. C. (2012). Genetic testing by cancer site: ovary. Cancer Journal (Sudbury, Mass.), 18(4), pp. 320-7. doi:10.1097/PPO.0b013e31826246c2.
Weissman SM, Weiss SM, Newlin AC. Genetic Testing By Cancer Site: Ovary. Cancer J. 2012;18(4):320-7. PubMed PMID: 22846732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic testing by cancer site: ovary. AU - Weissman,Scott M, AU - Weiss,Shelly M, AU - Newlin,Anna C, PY - 2012/8/1/entrez PY - 2012/8/1/pubmed PY - 2013/1/31/medline SP - 320 EP - 7 JF - Cancer journal (Sudbury, Mass.) JO - Cancer J VL - 18 IS - 4 N2 - Approximately 1 in every 4 to 5 women with a diagnosis of ovarian cancer has a hereditary gene mutation that is responsible for the development of her cancer. Identifying women at increased risk of developing ovarian cancer due to a hereditary cancer syndrome can allow for early detection or prevention of not only ovarian cancer, but also other cancers, depending on the causative gene. This review focuses on 3 of the most common hereditary ovarian cancer syndromes, hereditary breast and ovarian cancer syndrome (the BRCA1 and BRCA2 genes), Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer syndrome), and Peutz-Jeghers syndrome, including key features, genetics, and management of these syndromes. In addition, newly discovered genes (eg, RAD51C and RAD51D) linked to ovarian cancer are discussed. SN - 1540-336X UR - https://www.unboundmedicine.com/medline/citation/22846732/Genetic_testing_by_cancer_site:_ovary_ L2 - http://Insights.ovid.com/pubmed?pmid=22846732 DB - PRIME DP - Unbound Medicine ER -