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Successful treatment for Cronkhite-Canada syndrome with endoscopic mucosal resection and salazosulfapyridine.
Tech Coloproctol. 2014 May; 18(5):503-7.TC

Abstract

A 79-year-old woman was referred to our hospital because numerous polyps were found in her stomach and large intestine at an ambulatory clinic. Although there were no characteristic symptoms or signs of Cronkhite-Canada syndrome (CCS), endoscopic and pathological findings indicated CCS. Moreover, colonoscopy showed two polypoid lesions (Is type), which appeared neoplastic by magnifying observation with image-enhanced endoscopy (IEE), in the ascending colon. Histologically, the resected specimens revealed tubular adenomas arising in the CCS inflammatory polyps. Remarkable remission of the polyps and edematous mucosa in the stomach and colon was seen after 8 months of administration of salazosulfapyridine (SASP) (3 g/day). Another adenoma was detected and removed endoscopically in the sigmoid colon. This is the first report to describe an asymptomatic case of CCS probably detected in the early phase of the disease, by magnifying IEE which enabled detection and treatment for associated colonic adenomas. SASP was effective in eradication of the inflammatory polyposis, and an additional adenoma was successfully found and removed by surveillance colonoscopy thereafter.

Authors+Show Affiliations

Department of Gastroenterology, Juntendo University Nerima Hospital, 3-1-10 Nerimatakanodai, Nerima, Tokyo, 177-0033, Japan, psyro@juntendo.ac.jp.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22847839

Citation

Ueyama, H, et al. "Successful Treatment for Cronkhite-Canada Syndrome With Endoscopic Mucosal Resection and Salazosulfapyridine." Techniques in Coloproctology, vol. 18, no. 5, 2014, pp. 503-7.
Ueyama H, Fu KI, Ogura K, et al. Successful treatment for Cronkhite-Canada syndrome with endoscopic mucosal resection and salazosulfapyridine. Tech Coloproctol. 2014;18(5):503-7.
Ueyama, H., Fu, K. I., Ogura, K., Murata, S., & Miyazaki, A. (2014). Successful treatment for Cronkhite-Canada syndrome with endoscopic mucosal resection and salazosulfapyridine. Techniques in Coloproctology, 18(5), 503-7. https://doi.org/10.1007/s10151-012-0863-0
Ueyama H, et al. Successful Treatment for Cronkhite-Canada Syndrome With Endoscopic Mucosal Resection and Salazosulfapyridine. Tech Coloproctol. 2014;18(5):503-7. PubMed PMID: 22847839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment for Cronkhite-Canada syndrome with endoscopic mucosal resection and salazosulfapyridine. AU - Ueyama,H, AU - Fu,K I, AU - Ogura,K, AU - Murata,S, AU - Miyazaki,A, Y1 - 2012/07/31/ PY - 2011/10/15/received PY - 2012/07/05/accepted PY - 2012/8/1/entrez PY - 2012/8/1/pubmed PY - 2014/12/19/medline SP - 503 EP - 7 JF - Techniques in coloproctology JO - Tech Coloproctol VL - 18 IS - 5 N2 - A 79-year-old woman was referred to our hospital because numerous polyps were found in her stomach and large intestine at an ambulatory clinic. Although there were no characteristic symptoms or signs of Cronkhite-Canada syndrome (CCS), endoscopic and pathological findings indicated CCS. Moreover, colonoscopy showed two polypoid lesions (Is type), which appeared neoplastic by magnifying observation with image-enhanced endoscopy (IEE), in the ascending colon. Histologically, the resected specimens revealed tubular adenomas arising in the CCS inflammatory polyps. Remarkable remission of the polyps and edematous mucosa in the stomach and colon was seen after 8 months of administration of salazosulfapyridine (SASP) (3 g/day). Another adenoma was detected and removed endoscopically in the sigmoid colon. This is the first report to describe an asymptomatic case of CCS probably detected in the early phase of the disease, by magnifying IEE which enabled detection and treatment for associated colonic adenomas. SASP was effective in eradication of the inflammatory polyposis, and an additional adenoma was successfully found and removed by surveillance colonoscopy thereafter. SN - 1128-045X UR - https://www.unboundmedicine.com/medline/citation/22847839/Successful_treatment_for_Cronkhite_Canada_syndrome_with_endoscopic_mucosal_resection_and_salazosulfapyridine_ L2 - https://dx.doi.org/10.1007/s10151-012-0863-0 DB - PRIME DP - Unbound Medicine ER -