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Nanocalcium-deficient hydroxyapatite-poly (e-caprolactone)-polyethylene glycol-poly (e-caprolactone) composite scaffolds.
Int J Nanomedicine 2012; 7:3123-31IJ

Abstract

A bioactive composite of nano calcium-deficient apatite (n-CDAP) with an atom molar ratio of calcium to phosphate (Ca/P) of 1.50 and poly(ɛ-caprolactone)-poly(ethylene glycol)-poly(ɛ-caprolactone) (PCL-PEG-PCL) was synthesized, and a composite scaffold was fabricated. The composite scaffolds with 40 wt% n-CDAP contained well interconnected macropores around 400 μm, and exhibited a porosity of 75%. The weight-loss ratio of the n-CDAP/PCL-PEG-PCL was significantly greater than nano hydroxyapatite (n-HA, Ca/P = 1.67)/PCL-PEG-PCL composite scaffolds during soaking into phosphate-buffered saline (pH 7.4) for 70 days, indicating that n-CDAP-based composite had good degradability compared with n-HA. The viability ratio of MG-63 cells was significantly higher on n-CDAP than n-HA-based composite scaffolds at 3 and 5 days. In addition, the alkaline phosphatase activity of the MG-63 cells cultured on n-CDAP was higher than n-HA-based composite scaffolds at 7 days. Histological evaluation showed that the introduction of n-CDAP into PCL-PEG-PCL enhanced the efficiency of new bone formation when the composite scaffolds were implanted into rabbit bone defects. The results suggested that the n-CDAP-based composite exhibits good biocompatibility, biodegradation, and osteogenesis in vivo.

Authors+Show Affiliations

Department of Orthopedics, Shanghai Hospital, Second Military Medical University, Shanghai, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22848159

Citation

Wang, Zhiwei, et al. "Nanocalcium-deficient Hydroxyapatite-poly (e-caprolactone)-polyethylene Glycol-poly (e-caprolactone) Composite Scaffolds." International Journal of Nanomedicine, vol. 7, 2012, pp. 3123-31.
Wang Z, Li M, Yu B, et al. Nanocalcium-deficient hydroxyapatite-poly (e-caprolactone)-polyethylene glycol-poly (e-caprolactone) composite scaffolds. Int J Nanomedicine. 2012;7:3123-31.
Wang, Z., Li, M., Yu, B., Cao, L., Yang, Q., & Su, J. (2012). Nanocalcium-deficient hydroxyapatite-poly (e-caprolactone)-polyethylene glycol-poly (e-caprolactone) composite scaffolds. International Journal of Nanomedicine, 7, pp. 3123-31. doi:10.2147/IJN.S31162.
Wang Z, et al. Nanocalcium-deficient Hydroxyapatite-poly (e-caprolactone)-polyethylene Glycol-poly (e-caprolactone) Composite Scaffolds. Int J Nanomedicine. 2012;7:3123-31. PubMed PMID: 22848159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nanocalcium-deficient hydroxyapatite-poly (e-caprolactone)-polyethylene glycol-poly (e-caprolactone) composite scaffolds. AU - Wang,Zhiwei, AU - Li,Ming, AU - Yu,Baoqing, AU - Cao,Liehu, AU - Yang,Qingsong, AU - Su,Jiacan, Y1 - 2012/07/10/ PY - 2012/8/1/entrez PY - 2012/8/1/pubmed PY - 2013/2/22/medline KW - cell responses KW - composite scaffold KW - degradability KW - nano calcium-deficient apatite KW - osteogenesis SP - 3123 EP - 31 JF - International journal of nanomedicine JO - Int J Nanomedicine VL - 7 N2 - A bioactive composite of nano calcium-deficient apatite (n-CDAP) with an atom molar ratio of calcium to phosphate (Ca/P) of 1.50 and poly(ɛ-caprolactone)-poly(ethylene glycol)-poly(ɛ-caprolactone) (PCL-PEG-PCL) was synthesized, and a composite scaffold was fabricated. The composite scaffolds with 40 wt% n-CDAP contained well interconnected macropores around 400 μm, and exhibited a porosity of 75%. The weight-loss ratio of the n-CDAP/PCL-PEG-PCL was significantly greater than nano hydroxyapatite (n-HA, Ca/P = 1.67)/PCL-PEG-PCL composite scaffolds during soaking into phosphate-buffered saline (pH 7.4) for 70 days, indicating that n-CDAP-based composite had good degradability compared with n-HA. The viability ratio of MG-63 cells was significantly higher on n-CDAP than n-HA-based composite scaffolds at 3 and 5 days. In addition, the alkaline phosphatase activity of the MG-63 cells cultured on n-CDAP was higher than n-HA-based composite scaffolds at 7 days. Histological evaluation showed that the introduction of n-CDAP into PCL-PEG-PCL enhanced the efficiency of new bone formation when the composite scaffolds were implanted into rabbit bone defects. The results suggested that the n-CDAP-based composite exhibits good biocompatibility, biodegradation, and osteogenesis in vivo. SN - 1178-2013 UR - https://www.unboundmedicine.com/medline/citation/22848159/Nanocalcium_deficient_hydroxyapatite_poly__e_caprolactone__polyethylene_glycol_poly__e_caprolactone__composite_scaffolds_ L2 - https://dx.doi.org/10.2147/IJN.S31162 DB - PRIME DP - Unbound Medicine ER -