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Parathyroid hormone is associated with biomarkers of insulin resistance and inflammation, independent of vitamin D status, in obese adolescents.
Metab Syndr Relat Disord. 2012 Dec; 10(6):422-9.MS

Abstract

BACKGROUND

25-Hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) have been shown to correlate with several markers of metabolic syndrome in adult populations. We evaluated the relationship between circulating intact parathyroid hormone (iPTH) and 25(OH)D and indices of metabolic syndrome in obese adolescents.

METHODS

Body mass index (BMI), body composition, 25(OH)D, iPTH, fasting lipids, glucose, high-sensitivity C-reactive protein (hsCRP), glycosylated hemoglobin (HbA1c), insulin, and the homeostatic model assessment for insulin resistance (HOMA-IR) were evaluated in 133 obese adolescents.

RESULTS

Vitamin D deficiency [25(OH)D <50 nmol/L] was present in 45.1% of all patients, with higher prevalence in African-American (AA) and Hispanic (H) than Caucasian (C) subgroups (63.9% and 56.4% vs. 25.9%; P<0.001). iPTH and 25(OH)D were inversely correlated (r=-0.75; P<0.0001), with AA displaying a higher iPTH: 25(OH)D ratio than H and C subgroups (P<0.05). Whereas fat mass (FM) was negatively correlated with 25(OH)D (r=-0.30; p<0.001), it was positively correlated with iPTH levels (r=0.38; P<0.0001). Metabolic syndrome was identified in 57.9% of the cohort with higher iPTH, iPTH:25(OH)D ratio, but lower 25(OH)D than participants without metabolic syndrome (P<0.02). Whereas iPTH showed main effects for hsCRP (β=0.24, t=2.61, P<0.05) and triglycerides:high-density lipoprotein cholesterol (TG:HDL-C) (β=0.21, t=2.13, p<0.05), independent of serum 25(OH)D, it did not reveal a main effect for HOMA-IR.

CONCLUSIONS

Metabolic syndrome is associated with a higher iPTH:25(OH)D ratio than those without metabolic syndrome, implying greater risk of cardiovascular morbidities among AA subjects than other ethnic groups. Furthermore, the serum iPTH level is a predictor of chronic inflammation and dyslipidemia, independent of 25(OH)D.

Authors+Show Affiliations

Department of Pediatrics, University of Illinois at Chicago, Chicago, IL 60612, USA. ralemzad@uic.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22849753

Citation

Alemzadeh, Ramin, and Jessica Kichler. "Parathyroid Hormone Is Associated With Biomarkers of Insulin Resistance and Inflammation, Independent of Vitamin D Status, in Obese Adolescents." Metabolic Syndrome and Related Disorders, vol. 10, no. 6, 2012, pp. 422-9.
Alemzadeh R, Kichler J. Parathyroid hormone is associated with biomarkers of insulin resistance and inflammation, independent of vitamin D status, in obese adolescents. Metab Syndr Relat Disord. 2012;10(6):422-9.
Alemzadeh, R., & Kichler, J. (2012). Parathyroid hormone is associated with biomarkers of insulin resistance and inflammation, independent of vitamin D status, in obese adolescents. Metabolic Syndrome and Related Disorders, 10(6), 422-9. https://doi.org/10.1089/met.2012.0056
Alemzadeh R, Kichler J. Parathyroid Hormone Is Associated With Biomarkers of Insulin Resistance and Inflammation, Independent of Vitamin D Status, in Obese Adolescents. Metab Syndr Relat Disord. 2012;10(6):422-9. PubMed PMID: 22849753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parathyroid hormone is associated with biomarkers of insulin resistance and inflammation, independent of vitamin D status, in obese adolescents. AU - Alemzadeh,Ramin, AU - Kichler,Jessica, Y1 - 2012/07/31/ PY - 2012/8/2/entrez PY - 2012/8/2/pubmed PY - 2013/4/25/medline SP - 422 EP - 9 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 10 IS - 6 N2 - BACKGROUND: 25-Hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) have been shown to correlate with several markers of metabolic syndrome in adult populations. We evaluated the relationship between circulating intact parathyroid hormone (iPTH) and 25(OH)D and indices of metabolic syndrome in obese adolescents. METHODS: Body mass index (BMI), body composition, 25(OH)D, iPTH, fasting lipids, glucose, high-sensitivity C-reactive protein (hsCRP), glycosylated hemoglobin (HbA1c), insulin, and the homeostatic model assessment for insulin resistance (HOMA-IR) were evaluated in 133 obese adolescents. RESULTS: Vitamin D deficiency [25(OH)D <50 nmol/L] was present in 45.1% of all patients, with higher prevalence in African-American (AA) and Hispanic (H) than Caucasian (C) subgroups (63.9% and 56.4% vs. 25.9%; P<0.001). iPTH and 25(OH)D were inversely correlated (r=-0.75; P<0.0001), with AA displaying a higher iPTH: 25(OH)D ratio than H and C subgroups (P<0.05). Whereas fat mass (FM) was negatively correlated with 25(OH)D (r=-0.30; p<0.001), it was positively correlated with iPTH levels (r=0.38; P<0.0001). Metabolic syndrome was identified in 57.9% of the cohort with higher iPTH, iPTH:25(OH)D ratio, but lower 25(OH)D than participants without metabolic syndrome (P<0.02). Whereas iPTH showed main effects for hsCRP (β=0.24, t=2.61, P<0.05) and triglycerides:high-density lipoprotein cholesterol (TG:HDL-C) (β=0.21, t=2.13, p<0.05), independent of serum 25(OH)D, it did not reveal a main effect for HOMA-IR. CONCLUSIONS: Metabolic syndrome is associated with a higher iPTH:25(OH)D ratio than those without metabolic syndrome, implying greater risk of cardiovascular morbidities among AA subjects than other ethnic groups. Furthermore, the serum iPTH level is a predictor of chronic inflammation and dyslipidemia, independent of 25(OH)D. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/22849753/Parathyroid_hormone_is_associated_with_biomarkers_of_insulin_resistance_and_inflammation_independent_of_vitamin_D_status_in_obese_adolescents_ L2 - https://www.liebertpub.com/doi/full/10.1089/met.2012.0056?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -