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Effectiveness of 1 dose of influenza A (H1N1) 2009 monovalent vaccines in preventing reverse-transcription polymerase chain reaction-confirmed H1N1 infection among school-aged children in maine.
J Infect Dis. 2012 Oct 01; 206(7):1059-68.JI

Abstract

BACKGROUND

In late October 2009, school-located pandemic vaccination was initiated in Maine before or concurrent with 2009 pandemic influenza A (H1N1) virus (pH1N1) peak activity.

METHODS

A case-control evaluation of 2009 H1N1 vaccine effectiveness was conducted in schools in Cumberland County, Maine. A case was a child who had an acute respiratory illness during 2 November-18 December 2009, and who tested positive for pH1N1 by real-time reverse-transcription polymerase chain reaction (rRT-PCR). For each case, ≥ 4 event time-matched controls were sampled among classmates present in school during the study period who did not have an influenza-like illness. Vaccine effectiveness was calculated as (1 - adjusted odds ratio [aOR])100%; aOR was estimated by using weighted logistic regression.

RESULTS

After adjusting for a diagnosis of asthma, 1 dose of 2009 H1N1 vaccine provided 69% protection (95% confidence interval (CI), 13-89) against rRT-PCR-confirmed H1N1 infection. Vaccine effectiveness estimates for live attenuated and inactivated vaccine were 81% (95% CI, -37 to 97), and 58% (95% CI: -39 to 87), respectively.

CONCLUSIONS

One dose of monovalent pandemic vaccine provided substantial protection against pH1N1 infection among school-aged children.

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Authors+Show Affiliations

Uzicanin A
Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. aau5@cdc.gov
Thompson M
No affiliation info available
Smith P
No affiliation info available
Chaves SS
No affiliation info available
Foster L
No affiliation info available
Dube N
No affiliation info available
Graitcer S
No affiliation info available
Jackson R
No affiliation info available
Ferdinands J
No affiliation info available
Gargiullo P
No affiliation info available
Mills D
No affiliation info available
Monto AS
No affiliation info available
Shay DK
No affiliation info available
Maine 2009 Influenza A (H1N1) Vaccine Effectiveness Evaluation Group
No affiliation info available

MeSH

AdolescentCase-Control StudiesChildChild, PreschoolFemaleHumansInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesInfluenza, HumanLogistic ModelsMaineMalePandemicsRNA, ViralReverse Transcriptase Polymerase Chain ReactionTreatment OutcomeVaccines, Attenuated

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

22850120

Citation

Uzicanin, Amra, et al. "Effectiveness of 1 Dose of Influenza a (H1N1) 2009 Monovalent Vaccines in Preventing Reverse-transcription Polymerase Chain Reaction-confirmed H1N1 Infection Among School-aged Children in Maine." The Journal of Infectious Diseases, vol. 206, no. 7, 2012, pp. 1059-68.
Uzicanin A, Thompson M, Smith P, et al. Effectiveness of 1 dose of influenza A (H1N1) 2009 monovalent vaccines in preventing reverse-transcription polymerase chain reaction-confirmed H1N1 infection among school-aged children in maine. J Infect Dis. 2012;206(7):1059-68.
Uzicanin, A., Thompson, M., Smith, P., Chaves, S. S., Foster, L., Dube, N., Graitcer, S., Jackson, R., Ferdinands, J., Gargiullo, P., Mills, D., Monto, A. S., & Shay, D. K. (2012). Effectiveness of 1 dose of influenza A (H1N1) 2009 monovalent vaccines in preventing reverse-transcription polymerase chain reaction-confirmed H1N1 infection among school-aged children in maine. The Journal of Infectious Diseases, 206(7), 1059-68.
Uzicanin A, et al. Effectiveness of 1 Dose of Influenza a (H1N1) 2009 Monovalent Vaccines in Preventing Reverse-transcription Polymerase Chain Reaction-confirmed H1N1 Infection Among School-aged Children in Maine. J Infect Dis. 2012 Oct 1;206(7):1059-68. PubMed PMID: 22850120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of 1 dose of influenza A (H1N1) 2009 monovalent vaccines in preventing reverse-transcription polymerase chain reaction-confirmed H1N1 infection among school-aged children in maine. AU - Uzicanin,Amra, AU - Thompson,Mark, AU - Smith,Peter, AU - Chaves,Sandra S, AU - Foster,Lydia, AU - Dube,Nancy, AU - Graitcer,Samuel, AU - Jackson,Rebel, AU - Ferdinands,Jill, AU - Gargiullo,Paul, AU - Mills,Dora, AU - Monto,Arnold S, AU - Shay,David K, AU - ,, Y1 - 2012/07/30/ PY - 2012/8/2/entrez PY - 2012/8/2/pubmed PY - 2012/12/10/medline SP - 1059 EP - 68 JF - The Journal of infectious diseases JO - J Infect Dis VL - 206 IS - 7 N2 - BACKGROUND: In late October 2009, school-located pandemic vaccination was initiated in Maine before or concurrent with 2009 pandemic influenza A (H1N1) virus (pH1N1) peak activity. METHODS: A case-control evaluation of 2009 H1N1 vaccine effectiveness was conducted in schools in Cumberland County, Maine. A case was a child who had an acute respiratory illness during 2 November-18 December 2009, and who tested positive for pH1N1 by real-time reverse-transcription polymerase chain reaction (rRT-PCR). For each case, ≥ 4 event time-matched controls were sampled among classmates present in school during the study period who did not have an influenza-like illness. Vaccine effectiveness was calculated as (1 - adjusted odds ratio [aOR])100%; aOR was estimated by using weighted logistic regression. RESULTS: After adjusting for a diagnosis of asthma, 1 dose of 2009 H1N1 vaccine provided 69% protection (95% confidence interval (CI), 13-89) against rRT-PCR-confirmed H1N1 infection. Vaccine effectiveness estimates for live attenuated and inactivated vaccine were 81% (95% CI, -37 to 97), and 58% (95% CI: -39 to 87), respectively. CONCLUSIONS: One dose of monovalent pandemic vaccine provided substantial protection against pH1N1 infection among school-aged children. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/22850120/Effectiveness_of_1_dose_of_influenza_A__H1N1__2009_monovalent_vaccines_in_preventing_reverse_transcription_polymerase_chain_reaction_confirmed_H1N1_infection_among_school_aged_children_in_maine_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jis441 DB - PRIME DP - Unbound Medicine ER -