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Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats.

Abstract

PURPOSE

To determine the effects of water-soluble derivative of green propolis in bladder cancer angiogenesis in rats given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN).

METHODS

Nine groups were established, where six of them (Groups 1 to 6), the animals received 0.05% BBN in their drinking water for 14 weeks. From the 32nd to the 40th week, Groups 1, 2, 3 and 4 were treated respectively with water, L-lysine (300 mg/kg/day), celecoxib (30 mg/kg/day) and propolis (300 mg/kg/day). Groups 5 and 6 were given propolis and L-lysine from the 1st to the 40th week (150 mg/kg/day). Microvascular density was determined by histological sections stained for the marker CD-31 and analyzed with specific software.

RESULTS

The microvascular density in bladder carcinomas was lower (p<0.01) in rats receiving propolis than in controls given carcinogen only. On the other hand, the microvascular density of tumors in rats receiving carcinogen and L-lysine for 40 weeks from the beginning of carcinogen treatment was significantly higher (p<0.01) than in the corresponding controls.

CONCLUSION

Water-soluble derivative of propolis inhibits angiogenesis in BBN-induced rat bladder cancer, while L-lysine treatment stimulates angiogenesis if initiated concurrently with BBN.

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  • Authors+Show Affiliations

    ,

    Department of Pathology, UFC, Ceara, Brazil. eusoucondor@yahoo.com.br

    , , , , , , , , , , ,

    Source

    Acta cirurgica brasileira 27:8 2012 Aug pg 529-36

    MeSH

    Angiogenesis Inhibitors
    Animals
    Butylhydroxybutylnitrosamine
    Carcinoma
    Disease Models, Animal
    Female
    Lysine
    Neovascularization, Pathologic
    Plant Extracts
    Propolis
    Rats
    Rats, Wistar
    Time Factors
    Treatment Outcome
    Urinary Bladder Neoplasms
    Water

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22850703