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Effects of delta-aminolevulinic acid dehydratase polymorphisms on susceptibility to lead in Han subjects from southwestern China.

Abstract

This study is to determine the distribution of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism among Han subjects of the Chinese population and to study whether the polymorphism in the ALAD gene modifies the toxicity of lead in lead-exposed workers. For this purpose we conducted a cross-sectional study on 156 Chinese workers who were exposed to lead in lead-acid battery and electric-flex manufacturing plants. The authors found that the allele frequencies of ALAD1 and ALAD2 were 0.9679 and 0.0321, respectively. Workers with the ALAD 1-1 genotype were associated with higher blood lead levels than those with the ALAD 1-2 genotype. Blood and urine lead levels were much higher in storage battery workers than in cable workers. The self-conscious symptom survey showed that the incidences of debilitation, amnesia and dreaminess were much higher in those had more than five years of tenure or contact with lead on the job within the ALAD 1-1 genotype subgroup. Laboratory examinations showed that serum iron and zinc levels in workers' with the ALAD 1-2 genotype were higher than those with the ALAD 1-1 genotype, especially in storage-battery workers. Correlation analysis indicated that the blood lead level negatively correlated with serum calcium, iron and zinc level. The data of this study suggest that the ALAD gene polymorphism and serum ion levels may modify the kinetics of lead in blood. Therefore, the authors recommend that an adequate intake of dietary calcium, iron, and zinc or the calcium, iron, and zinc supplementation should be prescribed to Chinese lead exposed workers.

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  • Authors+Show Affiliations

    ,

    Department of Occupational Hygiene, West China Fourth Hospital of West China Public Health Institute, Sichuan University, 18 Renmin Nanlu, Chengdu, China. yuelinyangSCU@yahoo.com.cn

    ,

    Source

    MeSH

    Adult
    Asian Continental Ancestry Group
    China
    Cross-Sectional Studies
    Female
    Genetic Predisposition to Disease
    Humans
    Lead Poisoning
    Male
    Middle Aged
    Occupational Exposure
    Polymorphism, Genetic
    Porphobilinogen Synthase
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22851944

    Citation

    Yang, Yuelin, et al. "Effects of Delta-aminolevulinic Acid Dehydratase Polymorphisms On Susceptibility to Lead in Han Subjects From Southwestern China." International Journal of Environmental Research and Public Health, vol. 9, no. 7, 2012, pp. 2326-38.
    Yang Y, Wu J, Sun P. Effects of delta-aminolevulinic acid dehydratase polymorphisms on susceptibility to lead in Han subjects from southwestern China. Int J Environ Res Public Health. 2012;9(7):2326-38.
    Yang, Y., Wu, J., & Sun, P. (2012). Effects of delta-aminolevulinic acid dehydratase polymorphisms on susceptibility to lead in Han subjects from southwestern China. International Journal of Environmental Research and Public Health, 9(7), pp. 2326-38. doi:10.3390/ijerph9072326.
    Yang Y, Wu J, Sun P. Effects of Delta-aminolevulinic Acid Dehydratase Polymorphisms On Susceptibility to Lead in Han Subjects From Southwestern China. Int J Environ Res Public Health. 2012;9(7):2326-38. PubMed PMID: 22851944.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of delta-aminolevulinic acid dehydratase polymorphisms on susceptibility to lead in Han subjects from southwestern China. AU - Yang,Yuelin, AU - Wu,Jin, AU - Sun,Pin, Y1 - 2012/07/02/ PY - 2012/05/07/received PY - 2012/06/08/revised PY - 2012/06/25/accepted PY - 2012/8/2/entrez PY - 2012/8/2/pubmed PY - 2012/12/10/medline KW - Chinese KW - delta-aminolevulinic acid dehydratase KW - lead poisoning KW - occupational exposure KW - polymorphism SP - 2326 EP - 38 JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 9 IS - 7 N2 - This study is to determine the distribution of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism among Han subjects of the Chinese population and to study whether the polymorphism in the ALAD gene modifies the toxicity of lead in lead-exposed workers. For this purpose we conducted a cross-sectional study on 156 Chinese workers who were exposed to lead in lead-acid battery and electric-flex manufacturing plants. The authors found that the allele frequencies of ALAD1 and ALAD2 were 0.9679 and 0.0321, respectively. Workers with the ALAD 1-1 genotype were associated with higher blood lead levels than those with the ALAD 1-2 genotype. Blood and urine lead levels were much higher in storage battery workers than in cable workers. The self-conscious symptom survey showed that the incidences of debilitation, amnesia and dreaminess were much higher in those had more than five years of tenure or contact with lead on the job within the ALAD 1-1 genotype subgroup. Laboratory examinations showed that serum iron and zinc levels in workers' with the ALAD 1-2 genotype were higher than those with the ALAD 1-1 genotype, especially in storage-battery workers. Correlation analysis indicated that the blood lead level negatively correlated with serum calcium, iron and zinc level. The data of this study suggest that the ALAD gene polymorphism and serum ion levels may modify the kinetics of lead in blood. Therefore, the authors recommend that an adequate intake of dietary calcium, iron, and zinc or the calcium, iron, and zinc supplementation should be prescribed to Chinese lead exposed workers. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/22851944/Effects_of_delta_aminolevulinic_acid_dehydratase_polymorphisms_on_susceptibility_to_lead_in_Han_subjects_from_southwestern_China_ L2 - http://www.mdpi.com/resolver?pii=ijerph9072326 DB - PRIME DP - Unbound Medicine ER -