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Usefulness of acarbose and dietary modifications to limit glycemic variability following Roux-en-Y gastric bypass as assessed by continuous glucose monitoring.
Diabetes Technol Ther. 2012 Aug; 14(8):736-40.DT

Abstract

BACKGROUND

About 70% of the patients operated on for a gastric bypass (Roux-en-Y gastric bypass [RYGB]) suffer from dumping syndrome. In these patients, previous studies have demonstrated a high glycemic variability with hypoglycemia and with altered continuous glucose monitoring (CGM) profiles. The aim of this study was to evaluate the effect of treatment with dietary counseling plus acarbose administration on the symptoms and on the characteristics of the CGM profile.

SUBJECTS AND METHODS

Eight consecutive patients with dumping syndrome were given dietary counseling for 6 weeks and also treated with acarbose (50-100 mg three times a day). Their symptoms and the features of the CGM were compared before and after treatment.

RESULTS

The symptoms disappeared in seven patients. There was a significant increase in the time to the interstitial glucose (IG) peak and a reduction in the rate of the IG increase after a meal and in the rate of the IG decrease following the peak. The time below 60 mg/dL was significantly decreased, and the minimal IG value was significantly increased. The maximum and mean IG levels and the time above 140 mg/dL were decreased, but not significantly. Six patients spent more than 1% of the time with IG values below 60 mg/dL before treatment, but after treatment this was reduced to one patient. Before treatment only one patient had an IG level neither below 60 or above 140 mg/dL, and after treatment four patients were in this category.

CONCLUSIONS

Dietary counseling and acarbose treatment eliminated the symptoms and improved the CGM profile of patients suffering from dumping syndrome after RYGB.

Authors+Show Affiliations

Nutrition Unit, Cardiovascular and Metabolism Division, CHU of Toulouse, Hospital Larrey, Toulouse Cedex 09, France. Patrick.ritz@wanadoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

22853724

Citation

Ritz, Patrick, et al. "Usefulness of Acarbose and Dietary Modifications to Limit Glycemic Variability Following Roux-en-Y Gastric Bypass as Assessed By Continuous Glucose Monitoring." Diabetes Technology & Therapeutics, vol. 14, no. 8, 2012, pp. 736-40.
Ritz P, Vaurs C, Bertrand M, et al. Usefulness of acarbose and dietary modifications to limit glycemic variability following Roux-en-Y gastric bypass as assessed by continuous glucose monitoring. Diabetes Technol Ther. 2012;14(8):736-40.
Ritz, P., Vaurs, C., Bertrand, M., Anduze, Y., Guillaume, E., & Hanaire, H. (2012). Usefulness of acarbose and dietary modifications to limit glycemic variability following Roux-en-Y gastric bypass as assessed by continuous glucose monitoring. Diabetes Technology & Therapeutics, 14(8), 736-40. https://doi.org/10.1089/dia.2011.0302
Ritz P, et al. Usefulness of Acarbose and Dietary Modifications to Limit Glycemic Variability Following Roux-en-Y Gastric Bypass as Assessed By Continuous Glucose Monitoring. Diabetes Technol Ther. 2012;14(8):736-40. PubMed PMID: 22853724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of acarbose and dietary modifications to limit glycemic variability following Roux-en-Y gastric bypass as assessed by continuous glucose monitoring. AU - Ritz,Patrick, AU - Vaurs,Charlotte, AU - Bertrand,Monelle, AU - Anduze,Yves, AU - Guillaume,Eric, AU - Hanaire,Helene, PY - 2012/8/3/entrez PY - 2012/8/3/pubmed PY - 2012/12/19/medline SP - 736 EP - 40 JF - Diabetes technology & therapeutics JO - Diabetes Technol Ther VL - 14 IS - 8 N2 - BACKGROUND: About 70% of the patients operated on for a gastric bypass (Roux-en-Y gastric bypass [RYGB]) suffer from dumping syndrome. In these patients, previous studies have demonstrated a high glycemic variability with hypoglycemia and with altered continuous glucose monitoring (CGM) profiles. The aim of this study was to evaluate the effect of treatment with dietary counseling plus acarbose administration on the symptoms and on the characteristics of the CGM profile. SUBJECTS AND METHODS: Eight consecutive patients with dumping syndrome were given dietary counseling for 6 weeks and also treated with acarbose (50-100 mg three times a day). Their symptoms and the features of the CGM were compared before and after treatment. RESULTS: The symptoms disappeared in seven patients. There was a significant increase in the time to the interstitial glucose (IG) peak and a reduction in the rate of the IG increase after a meal and in the rate of the IG decrease following the peak. The time below 60 mg/dL was significantly decreased, and the minimal IG value was significantly increased. The maximum and mean IG levels and the time above 140 mg/dL were decreased, but not significantly. Six patients spent more than 1% of the time with IG values below 60 mg/dL before treatment, but after treatment this was reduced to one patient. Before treatment only one patient had an IG level neither below 60 or above 140 mg/dL, and after treatment four patients were in this category. CONCLUSIONS: Dietary counseling and acarbose treatment eliminated the symptoms and improved the CGM profile of patients suffering from dumping syndrome after RYGB. SN - 1557-8593 UR - https://www.unboundmedicine.com/medline/citation/22853724/Usefulness_of_acarbose_and_dietary_modifications_to_limit_glycemic_variability_following_Roux_en_Y_gastric_bypass_as_assessed_by_continuous_glucose_monitoring_ L2 - https://www.liebertpub.com/doi/10.1089/dia.2011.0302?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -