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Effects of an ethyl ester preparation of fish oils (Himega) on lipids and lipoproteins in hyperlipidaemia.
Aust N Z J Med 1990; 20(5):689-94AN

Abstract

Clinical trials were conducted to assess the utility of HimegaR in the management of hyperlipidaemia. Himega is an ethyl ester concentrate from fish oil containing at least 50% n-3 fatty acid and minimal cholesterol. In Study 1, 13 subjects with primary hypertriglyceridaemia consumed Himega or a triglyceride-based fish oil in a randomised, double-blind crossover study for 12 weeks. Nine subjects took 2 g/day of n-3 fatty acid but four subjects with marked hypertriglyceridaemia took 4 g/day. Plasma triglycerides were reduced by approximately 50% with either product. There was a very similar effect on all lipid and lipoprotein parameters, including an 18% increase in LDL cholesterol and 23% increase in serum apolipoprotein B. In Study 2, nine subjects with primary hypercholesterolaemia took 2 g/day of n-3 fatty acid (Himega) or placebo (olive oil) in a randomised, double-blind crossover study for nine weeks. Plasma cholesterol was reduced by 6%, without significant change in LDL cholesterol. Fish oils in the form of ethyl esters or triglyceride are assimilated to a similar degree and lead to equivalent triglyceride-lowering in hypertriglyceridaemia, while simultaneously increasing LDL particle numbers. Himega does not reduce LDL levels in hypercholesteraemia, despite being a product with minimal cholesterol content.

Authors+Show Affiliations

University of NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2285385

Citation

Simons, L A., et al. "Effects of an Ethyl Ester Preparation of Fish Oils (Himega) On Lipids and Lipoproteins in Hyperlipidaemia." Australian and New Zealand Journal of Medicine, vol. 20, no. 5, 1990, pp. 689-94.
Simons LA, Parfitt A, Simons J, et al. Effects of an ethyl ester preparation of fish oils (Himega) on lipids and lipoproteins in hyperlipidaemia. Aust N Z J Med. 1990;20(5):689-94.
Simons, L. A., Parfitt, A., Simons, J., & Balasubramaniam, S. (1990). Effects of an ethyl ester preparation of fish oils (Himega) on lipids and lipoproteins in hyperlipidaemia. Australian and New Zealand Journal of Medicine, 20(5), pp. 689-94.
Simons LA, et al. Effects of an Ethyl Ester Preparation of Fish Oils (Himega) On Lipids and Lipoproteins in Hyperlipidaemia. Aust N Z J Med. 1990;20(5):689-94. PubMed PMID: 2285385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of an ethyl ester preparation of fish oils (Himega) on lipids and lipoproteins in hyperlipidaemia. AU - Simons,L A, AU - Parfitt,A, AU - Simons,J, AU - Balasubramaniam,S, PY - 1990/10/1/pubmed PY - 1990/10/1/medline PY - 1990/10/1/entrez SP - 689 EP - 94 JF - Australian and New Zealand journal of medicine JO - Aust N Z J Med VL - 20 IS - 5 N2 - Clinical trials were conducted to assess the utility of HimegaR in the management of hyperlipidaemia. Himega is an ethyl ester concentrate from fish oil containing at least 50% n-3 fatty acid and minimal cholesterol. In Study 1, 13 subjects with primary hypertriglyceridaemia consumed Himega or a triglyceride-based fish oil in a randomised, double-blind crossover study for 12 weeks. Nine subjects took 2 g/day of n-3 fatty acid but four subjects with marked hypertriglyceridaemia took 4 g/day. Plasma triglycerides were reduced by approximately 50% with either product. There was a very similar effect on all lipid and lipoprotein parameters, including an 18% increase in LDL cholesterol and 23% increase in serum apolipoprotein B. In Study 2, nine subjects with primary hypercholesterolaemia took 2 g/day of n-3 fatty acid (Himega) or placebo (olive oil) in a randomised, double-blind crossover study for nine weeks. Plasma cholesterol was reduced by 6%, without significant change in LDL cholesterol. Fish oils in the form of ethyl esters or triglyceride are assimilated to a similar degree and lead to equivalent triglyceride-lowering in hypertriglyceridaemia, while simultaneously increasing LDL particle numbers. Himega does not reduce LDL levels in hypercholesteraemia, despite being a product with minimal cholesterol content. SN - 0004-8291 UR - https://www.unboundmedicine.com/medline/citation/2285385/Effects_of_an_ethyl_ester_preparation_of_fish_oils__Himega__on_lipids_and_lipoproteins_in_hyperlipidaemia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0004-8291&date=1990&volume=20&issue=5&spage=689 DB - PRIME DP - Unbound Medicine ER -