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Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption.
Am J Clin Nutr 2012; 96(3):665-71AJ

Abstract

BACKGROUND

Recent genome-wide association studies (GWASs) from populations of European descent identified single nucleotide polymorphisms (SNPs) in aryl-hydrocarbon receptor (AHR) and cytochrome P450 1A1 and 1A2 (CYP1A1-CYP1A2) genes that are associated with habitual caffeine and coffee consumption.

OBJECTIVE

We examined whether these SNPs (AHR: rs6968865 and rs4410790; CYP1A1-CYP1A2: rs2472297 and rs2470893) and 6 additional tag SNPs in the AHR gene were associated with habitual caffeine consumption in a Costa Rican population.

DESIGN

Subjects were from a case-control study of gene-diet interactions and myocardial infarction. Subjects with hypertension or missing information on smoking, caffeine intake, or genotype were excluded. Subjects were genotyped by using polymerase chain reaction with mass spectrometry-based detection, and caffeine intake was assessed by using a validated food-frequency questionnaire.

RESULTS

Compared with subjects who consumed <100 mg caffeine/d, subjects who consumed >400 mg caffeine/d were more likely to be carriers of the T, C, or T allele for rs6968865, rs4410790, and rs2472297, respectively. The corresponding ORs and 95% CIs were 1.41 (1.03, 1.93), 1.41 (1.04, 1.92), and 1.55 (1.01, 2.36). Multivariate-adjusted ORs (95% CIs) for rs6968865 were 1.44 (1.03, 2.00) for all subjects, 1.75 (1.16, 2.65) for nonsmokers, 1.15 (0.58, 2.30) for current smokers, 2.42 (1.45, 4.04) for subjects >57 y old, and 1.00 (0.65, 1.56) for subjects ≤57 y old. A similar effect modification was observed for rs4410790 but not for rs2472297.

CONCLUSION

Our findings show that previous associations between SNPs in AHR and CYP1A1-CYP1A2 and caffeine and coffee consumption from GWASs in European populations are also observed in an ethnically distinct Costa Rican population, but age and smoking are important effect modifiers.

Authors+Show Affiliations

Department of Nutritional Sciences, University of Toronto, Toronto, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22854411

Citation

Josse, Andrea R., et al. "Associations Between Polymorphisms in the AHR and CYP1A1-CYP1A2 Gene Regions and Habitual Caffeine Consumption." The American Journal of Clinical Nutrition, vol. 96, no. 3, 2012, pp. 665-71.
Josse AR, Da Costa LA, Campos H, et al. Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption. Am J Clin Nutr. 2012;96(3):665-71.
Josse, A. R., Da Costa, L. A., Campos, H., & El-Sohemy, A. (2012). Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption. The American Journal of Clinical Nutrition, 96(3), pp. 665-71. doi:10.3945/ajcn.112.038794.
Josse AR, et al. Associations Between Polymorphisms in the AHR and CYP1A1-CYP1A2 Gene Regions and Habitual Caffeine Consumption. Am J Clin Nutr. 2012;96(3):665-71. PubMed PMID: 22854411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption. AU - Josse,Andrea R, AU - Da Costa,Laura A, AU - Campos,Hannia, AU - El-Sohemy,Ahmed, Y1 - 2012/08/01/ PY - 2012/8/3/entrez PY - 2012/8/3/pubmed PY - 2012/10/27/medline SP - 665 EP - 71 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 96 IS - 3 N2 - BACKGROUND: Recent genome-wide association studies (GWASs) from populations of European descent identified single nucleotide polymorphisms (SNPs) in aryl-hydrocarbon receptor (AHR) and cytochrome P450 1A1 and 1A2 (CYP1A1-CYP1A2) genes that are associated with habitual caffeine and coffee consumption. OBJECTIVE: We examined whether these SNPs (AHR: rs6968865 and rs4410790; CYP1A1-CYP1A2: rs2472297 and rs2470893) and 6 additional tag SNPs in the AHR gene were associated with habitual caffeine consumption in a Costa Rican population. DESIGN: Subjects were from a case-control study of gene-diet interactions and myocardial infarction. Subjects with hypertension or missing information on smoking, caffeine intake, or genotype were excluded. Subjects were genotyped by using polymerase chain reaction with mass spectrometry-based detection, and caffeine intake was assessed by using a validated food-frequency questionnaire. RESULTS: Compared with subjects who consumed <100 mg caffeine/d, subjects who consumed >400 mg caffeine/d were more likely to be carriers of the T, C, or T allele for rs6968865, rs4410790, and rs2472297, respectively. The corresponding ORs and 95% CIs were 1.41 (1.03, 1.93), 1.41 (1.04, 1.92), and 1.55 (1.01, 2.36). Multivariate-adjusted ORs (95% CIs) for rs6968865 were 1.44 (1.03, 2.00) for all subjects, 1.75 (1.16, 2.65) for nonsmokers, 1.15 (0.58, 2.30) for current smokers, 2.42 (1.45, 4.04) for subjects >57 y old, and 1.00 (0.65, 1.56) for subjects ≤57 y old. A similar effect modification was observed for rs4410790 but not for rs2472297. CONCLUSION: Our findings show that previous associations between SNPs in AHR and CYP1A1-CYP1A2 and caffeine and coffee consumption from GWASs in European populations are also observed in an ethnically distinct Costa Rican population, but age and smoking are important effect modifiers. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22854411/Associations_between_polymorphisms_in_the_AHR_and_CYP1A1_CYP1A2_gene_regions_and_habitual_caffeine_consumption_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.038794 DB - PRIME DP - Unbound Medicine ER -