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The effect of soy protein beverages on serum cell adhesion molecule concentrations in prehypertensive/stage 1 hypertensive individuals.
J Am Coll Nutr. 2012 Apr; 31(2):100-10.JA

Abstract

OBJECTIVE

Prehypertensive and hypertensive individuals are at increased risk of atherosclerotic cardiovascular disease (CVD), in part because hypertension contributes to endothelial dysfunction and increased cell adhesion molecule expression. Soy protein and isoflavones may favorably alter CVD risk factors, and hence the aim of this study was to determine whether intake of cow's milk compared with soy beverage prepared from whole soy bean (WSB) or soy protein isolate (SPI) would lower soluble cell adhesion molecule concentrations as a means of decreasing CVD risk.

METHODS

We enrolled healthy prehypertensive/stage 1 hypertensive men (n = 60; 18-63 years) and premenopausal women (n = 8; 20-48 years). Participants were randomized to 1 of 3 groups for 8 weeks: cow's milk (600 mL/d), SPI beverage (840 mL/d; 30.1 mg total isoflavones/d), or WSB beverage (840 mL/d; 91.4 mg total isoflavones/d). We measured soluble vascular cell adhesion molecule-1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), and endothelial-leukocyte adhesion molecule-1 (E-selectin) concentrations at baseline and week 8.

RESULTS

Soluble CAM concentrations were not altered by treatment and did not differ between prehypertensive and hypertensive participants. However, analysis of variance indicated a treatment × gender interaction (gender effect) for ICAM-1 (p = 0.0037) but not for E-selectin (p = 0.067) or VCAM-1 (p = 0.16). Men had higher concentrations of ICAM-1 and E-selectin, respectively, at baseline (p = 0.0071, p = 0.049) and week 8 (p = 0.0054, p = 0.038) than women did.

CONCLUSION

Neither intake of cow's milk nor soy beverage for 8 weeks altered soluble CAM concentrations in prehypertensive/stage 1 hypertensive individuals, suggesting that neither type of beverage diminished atherosclerotic CVD risk in mildly hypertensive individuals by way of improving circulating CAM concentrations.

Authors+Show Affiliations

Department of Food Science & Human Nutrition, Nutrition & Wellness Research Center, Research Park, Ames, Iowa, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22855915

Citation

Dettmer, Michelle, et al. "The Effect of Soy Protein Beverages On Serum Cell Adhesion Molecule Concentrations in Prehypertensive/stage 1 Hypertensive Individuals." Journal of the American College of Nutrition, vol. 31, no. 2, 2012, pp. 100-10.
Dettmer M, Alekel DL, Lasrado JA, et al. The effect of soy protein beverages on serum cell adhesion molecule concentrations in prehypertensive/stage 1 hypertensive individuals. J Am Coll Nutr. 2012;31(2):100-10.
Dettmer, M., Alekel, D. L., Lasrado, J. A., Messina, M., Carriquiry, A., Heiberger, K., Stewart, J. W., & Franke, W. (2012). The effect of soy protein beverages on serum cell adhesion molecule concentrations in prehypertensive/stage 1 hypertensive individuals. Journal of the American College of Nutrition, 31(2), 100-10.
Dettmer M, et al. The Effect of Soy Protein Beverages On Serum Cell Adhesion Molecule Concentrations in Prehypertensive/stage 1 Hypertensive Individuals. J Am Coll Nutr. 2012;31(2):100-10. PubMed PMID: 22855915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of soy protein beverages on serum cell adhesion molecule concentrations in prehypertensive/stage 1 hypertensive individuals. AU - Dettmer,Michelle, AU - Alekel,D Lee, AU - Lasrado,Joanne A, AU - Messina,Mark, AU - Carriquiry,Alicia, AU - Heiberger,Kevin, AU - Stewart,Jeanne W, AU - Franke,Warren, PY - 2012/8/3/entrez PY - 2012/8/3/pubmed PY - 2012/12/12/medline SP - 100 EP - 10 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 31 IS - 2 N2 - OBJECTIVE: Prehypertensive and hypertensive individuals are at increased risk of atherosclerotic cardiovascular disease (CVD), in part because hypertension contributes to endothelial dysfunction and increased cell adhesion molecule expression. Soy protein and isoflavones may favorably alter CVD risk factors, and hence the aim of this study was to determine whether intake of cow's milk compared with soy beverage prepared from whole soy bean (WSB) or soy protein isolate (SPI) would lower soluble cell adhesion molecule concentrations as a means of decreasing CVD risk. METHODS: We enrolled healthy prehypertensive/stage 1 hypertensive men (n = 60; 18-63 years) and premenopausal women (n = 8; 20-48 years). Participants were randomized to 1 of 3 groups for 8 weeks: cow's milk (600 mL/d), SPI beverage (840 mL/d; 30.1 mg total isoflavones/d), or WSB beverage (840 mL/d; 91.4 mg total isoflavones/d). We measured soluble vascular cell adhesion molecule-1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), and endothelial-leukocyte adhesion molecule-1 (E-selectin) concentrations at baseline and week 8. RESULTS: Soluble CAM concentrations were not altered by treatment and did not differ between prehypertensive and hypertensive participants. However, analysis of variance indicated a treatment × gender interaction (gender effect) for ICAM-1 (p = 0.0037) but not for E-selectin (p = 0.067) or VCAM-1 (p = 0.16). Men had higher concentrations of ICAM-1 and E-selectin, respectively, at baseline (p = 0.0071, p = 0.049) and week 8 (p = 0.0054, p = 0.038) than women did. CONCLUSION: Neither intake of cow's milk nor soy beverage for 8 weeks altered soluble CAM concentrations in prehypertensive/stage 1 hypertensive individuals, suggesting that neither type of beverage diminished atherosclerotic CVD risk in mildly hypertensive individuals by way of improving circulating CAM concentrations. SN - 1541-1087 UR - https://www.unboundmedicine.com/medline/citation/22855915/The_effect_of_soy_protein_beverages_on_serum_cell_adhesion_molecule_concentrations_in_prehypertensive/stage_1_hypertensive_individuals_ L2 - https://www.tandfonline.com/doi/full/10.1080/07315724.2012.10720015 DB - PRIME DP - Unbound Medicine ER -