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Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia.
Coll Antropol. 2012 Jun; 36(2):401-8.CA

Abstract

In 80 adult patients with community acquired pneumonia (CAP) conventional microbiological methods, polymerase chain reaction (PCR) and serum C-reactive protein (CRP) levels were performed and the appropriateness of the empirical antimicrobial treatment was evaluated according to bacterial pathogen detected. The aetiology was determined in 42 (52.5%) patients, with Streptococcus pneumoniae as the most common pathogen. PCR applied to bronchoalveolar lavage (BAL) provided 2 and PCR on sputum samples 1 additional aetiological diagnosis of CAP The mean CRP values in the S. pneumoniae group were not significantly higher than in the group with other aetiological diagnoses (166.89 mg/L vs. 160.11 mg/L, p = 0.457). In 23.8% (10/42) of patients with determined aetiology, the empirical antimicrobial treatment was inappropriate. PCR tests need further investigation, particularly those for the atypical pathogens, as they are predominant in inappropriately treated patients. Our results do not support the use of CRP as a rapid test to guide the antimicrobial treatment in patients with CAP.

Authors+Show Affiliations

University of Zagreb, Zagreb University Hospital Center, Department of Clinical and Molecular Microbiology, Zagreb, Croatia. ivanamarekovic@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22856222

Citation

Mareković, Ivana, et al. "Value of Rapid Aetiological Diagnosis in Optimization of Antimicrobial Treatment in Bacterial Community Acquired Pneumonia." Collegium Antropologicum, vol. 36, no. 2, 2012, pp. 401-8.
Mareković I, Plecko V, Boras Z, et al. Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia. Coll Antropol. 2012;36(2):401-8.
Mareković, I., Plecko, V., Boras, Z., Pavlović, L., Budimir, A., Bosnjak, Z., Puretić, H., Zele-Starcević, L., & Kalenić, S. (2012). Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia. Collegium Antropologicum, 36(2), 401-8.
Mareković I, et al. Value of Rapid Aetiological Diagnosis in Optimization of Antimicrobial Treatment in Bacterial Community Acquired Pneumonia. Coll Antropol. 2012;36(2):401-8. PubMed PMID: 22856222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia. AU - Mareković,Ivana, AU - Plecko,Vanda, AU - Boras,Zagorka, AU - Pavlović,Ladislav, AU - Budimir,Ana, AU - Bosnjak,Zrinka, AU - Puretić,Hrvoje, AU - Zele-Starcević,Lidija, AU - Kalenić,Smilja, PY - 2012/8/4/entrez PY - 2012/8/4/pubmed PY - 2012/8/31/medline SP - 401 EP - 8 JF - Collegium antropologicum JO - Coll Antropol VL - 36 IS - 2 N2 - In 80 adult patients with community acquired pneumonia (CAP) conventional microbiological methods, polymerase chain reaction (PCR) and serum C-reactive protein (CRP) levels were performed and the appropriateness of the empirical antimicrobial treatment was evaluated according to bacterial pathogen detected. The aetiology was determined in 42 (52.5%) patients, with Streptococcus pneumoniae as the most common pathogen. PCR applied to bronchoalveolar lavage (BAL) provided 2 and PCR on sputum samples 1 additional aetiological diagnosis of CAP The mean CRP values in the S. pneumoniae group were not significantly higher than in the group with other aetiological diagnoses (166.89 mg/L vs. 160.11 mg/L, p = 0.457). In 23.8% (10/42) of patients with determined aetiology, the empirical antimicrobial treatment was inappropriate. PCR tests need further investigation, particularly those for the atypical pathogens, as they are predominant in inappropriately treated patients. Our results do not support the use of CRP as a rapid test to guide the antimicrobial treatment in patients with CAP. SN - 0350-6134 UR - https://www.unboundmedicine.com/medline/citation/22856222/Value_of_rapid_aetiological_diagnosis_in_optimization_of_antimicrobial_treatment_in_bacterial_community_acquired_pneumonia_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -