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GnRH-agonist ovulation trigger in patients undergoing controlled ovarian hyperstimulation for IVF with ultrashort flare GnRH-agonist combined with multidose GnRH-antagonist protocol.
Gynecol Endocrinol. 2013 Jan; 29(1):51-3.GE

Abstract

OBJECTIVE

To evaluate, whether Gonadotropin-releasing hormone-agonist (GnRH-agonist or GnRH-ag) trigger in patients undergoing the ultrashort GnRH-ag/GnRH-antagonist (GnRH-ant) protocol is as effective as in patients at high risk to develop severe ovarian hyperstimulation syndrome (OHSS), who undergo the multidose GnRH-ant protocol.

DESIGN

Cohort study.

SETTING

University hospital.

PATIENTS

All consecutive women aged ≤35 years admitted to our IVF unit from January 2011 to October 2011 who reached the ovum pick-up stage.

INTERVENTIONS

Triggering final oocytes maturation by GnRH-ag instead of hCG, in high-responder patients undergoing either the ultrashort GnRH-ag/GnRH-ant or the multidose GnRH-antagonist controlled ovarian hyperstimulation (COH) protocols.

MAIN OUTCOME MEASURES

Ovarian stimulation characteristics, percentage of mature oocytes, fertilization and pregnancy rates.

RESULTS

No inbetween groups differences were observed in ovarian-stimulation related variable, percentage of mature oocytes, fertilization or pregnancy rates. No case of moderate-severe OHSS was reported in the study, or the control groups.

CONCLUSIONS

Three consecutive doses of daily GnRH-ag administration at the beginning of ultrashort flare GnRH-ag/GnRH-ant COH protocol, did not interfere with the ability of the GnRH-ag to trigger final oocytes maturation at the end of the COH cycle.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Barzilai Medical Centre, Ashkelon, Israel. raoulo@barzi.health.gov.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22857268

Citation

Orvieto, Raoul, et al. "GnRH-agonist Ovulation Trigger in Patients Undergoing Controlled Ovarian Hyperstimulation for IVF With Ultrashort Flare GnRH-agonist Combined With Multidose GnRH-antagonist Protocol." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 29, no. 1, 2013, pp. 51-3.
Orvieto R, Nahum R, Zohav E, et al. GnRH-agonist ovulation trigger in patients undergoing controlled ovarian hyperstimulation for IVF with ultrashort flare GnRH-agonist combined with multidose GnRH-antagonist protocol. Gynecol Endocrinol. 2013;29(1):51-3.
Orvieto, R., Nahum, R., Zohav, E., Liberty, G., Anteby, E. Y., & Meltcer, S. (2013). GnRH-agonist ovulation trigger in patients undergoing controlled ovarian hyperstimulation for IVF with ultrashort flare GnRH-agonist combined with multidose GnRH-antagonist protocol. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 29(1), 51-3. https://doi.org/10.3109/09513590.2012.705376
Orvieto R, et al. GnRH-agonist Ovulation Trigger in Patients Undergoing Controlled Ovarian Hyperstimulation for IVF With Ultrashort Flare GnRH-agonist Combined With Multidose GnRH-antagonist Protocol. Gynecol Endocrinol. 2013;29(1):51-3. PubMed PMID: 22857268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - GnRH-agonist ovulation trigger in patients undergoing controlled ovarian hyperstimulation for IVF with ultrashort flare GnRH-agonist combined with multidose GnRH-antagonist protocol. AU - Orvieto,Raoul, AU - Nahum,Ravit, AU - Zohav,Efraim, AU - Liberty,Gad, AU - Anteby,Eyal Y, AU - Meltcer,Simion, Y1 - 2012/08/03/ PY - 2012/8/4/entrez PY - 2012/8/4/pubmed PY - 2013/5/29/medline SP - 51 EP - 3 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 29 IS - 1 N2 - OBJECTIVE: To evaluate, whether Gonadotropin-releasing hormone-agonist (GnRH-agonist or GnRH-ag) trigger in patients undergoing the ultrashort GnRH-ag/GnRH-antagonist (GnRH-ant) protocol is as effective as in patients at high risk to develop severe ovarian hyperstimulation syndrome (OHSS), who undergo the multidose GnRH-ant protocol. DESIGN: Cohort study. SETTING: University hospital. PATIENTS: All consecutive women aged ≤35 years admitted to our IVF unit from January 2011 to October 2011 who reached the ovum pick-up stage. INTERVENTIONS: Triggering final oocytes maturation by GnRH-ag instead of hCG, in high-responder patients undergoing either the ultrashort GnRH-ag/GnRH-ant or the multidose GnRH-antagonist controlled ovarian hyperstimulation (COH) protocols. MAIN OUTCOME MEASURES: Ovarian stimulation characteristics, percentage of mature oocytes, fertilization and pregnancy rates. RESULTS: No inbetween groups differences were observed in ovarian-stimulation related variable, percentage of mature oocytes, fertilization or pregnancy rates. No case of moderate-severe OHSS was reported in the study, or the control groups. CONCLUSIONS: Three consecutive doses of daily GnRH-ag administration at the beginning of ultrashort flare GnRH-ag/GnRH-ant COH protocol, did not interfere with the ability of the GnRH-ag to trigger final oocytes maturation at the end of the COH cycle. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/22857268/GnRH_agonist_ovulation_trigger_in_patients_undergoing_controlled_ovarian_hyperstimulation_for_IVF_with_ultrashort_flare_GnRH_agonist_combined_with_multidose_GnRH_antagonist_protocol_ L2 - https://www.tandfonline.com/doi/full/10.3109/09513590.2012.705376 DB - PRIME DP - Unbound Medicine ER -