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Relation between chemical composition or antioxidant activity and antihypertensive activity for six essential oils.
J Food Sci. 2012 Aug; 77(8):H184-91.JF

Abstract

Six essential oils (EOs), Juniperus phoenicea (leaves and berries), Thymus capitatus, Lauris nobilis, Melaleuca armillaris, and Eucalyptus gracilis, were screened for their antioxidant and antihypertensive activity as well as their chemical compositions. We identified and quantified 24 compounds (representing 99.8% of total oil) for J. phoenicea leaves, 14 compounds (representing 98.8% of total oil) for J. phoenicea berries, 11 compounds (representing 99.6% of total oil) for T. capitatus, 32 compounds (representing 98.9% of total oil) for L. nobilis, 32 compounds (representing 98.7% of total oil) for M. armillaris, and 26 compounds (representing 99.3% of total oil) for E. gracilis. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, the antioxidant activity was in the range of 0.59 to 2183.6 mg/L, whereas T. capitatus (1.24 ± 0.05 mg/L) gave the best activity in the 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonate assay. Antihypertensive activity was evaluated by testing the vasorelaxing capacity of EOs on rat aorta precontracted by phenylephrine (10(-6) M). T. capitatus and L. nobilis were most active for an antihypertensive activity (29 ± 3 and 59 ± 2 mg/L, respectively). Correlations between chemical composition or antioxidant activity and/or antihypertensive activity were studied. Significant correlation has been found for antihypertensive activity and p-cymene (R(2) = 0.86), β-elemene (R(2) = 0.90), and β-myrcene (R(2) = 0.76). A good correlation has been found between antihypertensive activity and antioxidant activity by DPPH assay (R(2) = 0.98). Antioxidant activity can contribute to the prevention of the increase of the blood pressure. According to the literature, no study has been reported until now of correlation between antihypertensive activity and antioxidant activity. Natural EOs can find its interest and application in a medicinal area.

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Authors+Show Affiliations

Yvon Y
Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique, Université de Toulouse, UMR CNRS 5623, Université Paul-Sabatier, Toulouse, France.
Raoelison EG
No affiliation info available
Razafindrazaka R
No affiliation info available
Randriantsoa A
No affiliation info available
Romdhane M
No affiliation info available
Chabir N
No affiliation info available
Mkaddem MG
No affiliation info available
Bouajila J
No affiliation info available

MeSH

Acyclic MonoterpenesAnimalsAntihypertensive AgentsAntioxidantsBiphenyl CompoundsBlood PressureCymenesFruitGas Chromatography-Mass SpectrometryJuniperusLinear ModelsMelaleucaMonoterpenesOils, VolatilePicratesPlant ExtractsPlant LeavesRatsRats, WistarSesquiterpenesThymus PlantVasodilator Agents

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22860587

Citation

Yvon, Yan, et al. "Relation Between Chemical Composition or Antioxidant Activity and Antihypertensive Activity for Six Essential Oils." Journal of Food Science, vol. 77, no. 8, 2012, pp. H184-91.
Yvon Y, Raoelison EG, Razafindrazaka R, et al. Relation between chemical composition or antioxidant activity and antihypertensive activity for six essential oils. J Food Sci. 2012;77(8):H184-91.
Yvon, Y., Raoelison, E. G., Razafindrazaka, R., Randriantsoa, A., Romdhane, M., Chabir, N., Mkaddem, M. G., & Bouajila, J. (2012). Relation between chemical composition or antioxidant activity and antihypertensive activity for six essential oils. Journal of Food Science, 77(8), H184-91. https://doi.org/10.1111/j.1750-3841.2012.02812.x
Yvon Y, et al. Relation Between Chemical Composition or Antioxidant Activity and Antihypertensive Activity for Six Essential Oils. J Food Sci. 2012;77(8):H184-91. PubMed PMID: 22860587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation between chemical composition or antioxidant activity and antihypertensive activity for six essential oils. AU - Yvon,Yan, AU - Raoelison,Emmanuel Guy, AU - Razafindrazaka,René, AU - Randriantsoa,Adolphe, AU - Romdhane,Mehrez, AU - Chabir,Naziha, AU - Mkaddem,Mounira Guedri, AU - Bouajila,Jalloul, PY - 2012/8/7/entrez PY - 2012/8/7/pubmed PY - 2012/12/12/medline SP - H184 EP - 91 JF - Journal of food science JO - J Food Sci VL - 77 IS - 8 N2 - Six essential oils (EOs), Juniperus phoenicea (leaves and berries), Thymus capitatus, Lauris nobilis, Melaleuca armillaris, and Eucalyptus gracilis, were screened for their antioxidant and antihypertensive activity as well as their chemical compositions. We identified and quantified 24 compounds (representing 99.8% of total oil) for J. phoenicea leaves, 14 compounds (representing 98.8% of total oil) for J. phoenicea berries, 11 compounds (representing 99.6% of total oil) for T. capitatus, 32 compounds (representing 98.9% of total oil) for L. nobilis, 32 compounds (representing 98.7% of total oil) for M. armillaris, and 26 compounds (representing 99.3% of total oil) for E. gracilis. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, the antioxidant activity was in the range of 0.59 to 2183.6 mg/L, whereas T. capitatus (1.24 ± 0.05 mg/L) gave the best activity in the 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonate assay. Antihypertensive activity was evaluated by testing the vasorelaxing capacity of EOs on rat aorta precontracted by phenylephrine (10(-6) M). T. capitatus and L. nobilis were most active for an antihypertensive activity (29 ± 3 and 59 ± 2 mg/L, respectively). Correlations between chemical composition or antioxidant activity and/or antihypertensive activity were studied. Significant correlation has been found for antihypertensive activity and p-cymene (R(2) = 0.86), β-elemene (R(2) = 0.90), and β-myrcene (R(2) = 0.76). A good correlation has been found between antihypertensive activity and antioxidant activity by DPPH assay (R(2) = 0.98). Antioxidant activity can contribute to the prevention of the increase of the blood pressure. According to the literature, no study has been reported until now of correlation between antihypertensive activity and antioxidant activity. Natural EOs can find its interest and application in a medicinal area. SN - 1750-3841 UR - https://www.unboundmedicine.com/medline/citation/22860587/Relation_between_chemical_composition_or_antioxidant_activity_and_antihypertensive_activity_for_six_essential_oils_ L2 - https://doi.org/10.1111/j.1750-3841.2012.02812.x DB - PRIME DP - Unbound Medicine ER -