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Fruit, vegetable, and animal food intake and breast cancer risk by hormone receptor status.

Abstract

The effects of diet on breast cancer are controversial and whether the effects vary with hormone receptor status has not been well investigated. This study evaluated the associations of dietary factors with risk for breast cancer overall and by the hormone receptor status of tumors among Chinese women. The Shanghai Breast Cancer Study, a large, population-based, case-control study, enrolled 3,443 cases and 3,474 controls in 1996-1998 (phase I) and 2002-2005 (phase II); 2676 cases had estrogen receptor (ER) and progesterone receptor (PR) data. Dietary intake was assessed using a validated, quantitative, food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (95% CI) were derived from multivariate, polychotomous, unconditional logistic regression models. Total vegetable intake was inversely related to breast cancer risk, with an adjusted OR for the highest quintile of 0.80 (95% CI = 0.67-0.95; P trend = 0.02). Reduced risk was also related to high intake of allium vegetables (P trend = 0.01) and fresh legumes (P trend = 0.0008). High intake of citrus fruits and rosaceae fruits were inversely associated with breast cancer risk (P trend = 0.003 and 0.004, respectively), although no consistent association was seen for total fruit intake. Elevated risk was observed for all types of meat and fish intake (all P trend < 0.05), whereas intakes of eggs and milk were associated with a decreased risk of breast cancer (both P trend <0.05). There was little evidence that associations with dietary intakes varied across the 4 tumor subtypes or between ER+/PR+ and ER-/PR- tumors (P for heterogeneity >0.05). Our results suggest that high intake of total vegetables, certain fruits, milk, and eggs may reduce the risk of breast cancer, whereas high consumption of animal-source foods may increase risk. The dietary associations did not appear to vary by ER/PR status.

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  • Authors+Show Affiliations

    ,

    Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People's Republic of China.

    , , , , , , , ,

    Source

    Nutrition and cancer 64:6 2012 Aug pg 806-19

    MeSH

    Adult
    Aged
    Allium
    Animals
    Breast Neoplasms
    Case-Control Studies
    China
    Diet
    Eating
    Eggs
    Female
    Fish Products
    Fruit
    Humans
    Logistic Models
    Meat Products
    Middle Aged
    Milk
    Odds Ratio
    Receptors, Estrogen
    Receptors, Progesterone
    Risk Factors
    Surveys and Questionnaires
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    22860889

    Citation

    Bao, Ping-Ping, et al. "Fruit, Vegetable, and Animal Food Intake and Breast Cancer Risk By Hormone Receptor Status." Nutrition and Cancer, vol. 64, no. 6, 2012, pp. 806-19.
    Bao PP, Shu XO, Zheng Y, et al. Fruit, vegetable, and animal food intake and breast cancer risk by hormone receptor status. Nutr Cancer. 2012;64(6):806-19.
    Bao, P. P., Shu, X. O., Zheng, Y., Cai, H., Ruan, Z. X., Gu, K., ... Lu, W. (2012). Fruit, vegetable, and animal food intake and breast cancer risk by hormone receptor status. Nutrition and Cancer, 64(6), pp. 806-19. doi:10.1080/01635581.2012.707277.
    Bao PP, et al. Fruit, Vegetable, and Animal Food Intake and Breast Cancer Risk By Hormone Receptor Status. Nutr Cancer. 2012;64(6):806-19. PubMed PMID: 22860889.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruit, vegetable, and animal food intake and breast cancer risk by hormone receptor status. AU - Bao,Ping-Ping, AU - Shu,Xiao-Ou, AU - Zheng,Ying, AU - Cai,Hui, AU - Ruan,Zhi-Xian, AU - Gu,Kai, AU - Su,Yinghao, AU - Gao,Yu-Tang, AU - Zheng,Wei, AU - Lu,Wei, Y1 - 2012/08/03/ PY - 2012/8/7/entrez PY - 2012/8/7/pubmed PY - 2013/2/5/medline SP - 806 EP - 19 JF - Nutrition and cancer JO - Nutr Cancer VL - 64 IS - 6 N2 - The effects of diet on breast cancer are controversial and whether the effects vary with hormone receptor status has not been well investigated. This study evaluated the associations of dietary factors with risk for breast cancer overall and by the hormone receptor status of tumors among Chinese women. The Shanghai Breast Cancer Study, a large, population-based, case-control study, enrolled 3,443 cases and 3,474 controls in 1996-1998 (phase I) and 2002-2005 (phase II); 2676 cases had estrogen receptor (ER) and progesterone receptor (PR) data. Dietary intake was assessed using a validated, quantitative, food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (95% CI) were derived from multivariate, polychotomous, unconditional logistic regression models. Total vegetable intake was inversely related to breast cancer risk, with an adjusted OR for the highest quintile of 0.80 (95% CI = 0.67-0.95; P trend = 0.02). Reduced risk was also related to high intake of allium vegetables (P trend = 0.01) and fresh legumes (P trend = 0.0008). High intake of citrus fruits and rosaceae fruits were inversely associated with breast cancer risk (P trend = 0.003 and 0.004, respectively), although no consistent association was seen for total fruit intake. Elevated risk was observed for all types of meat and fish intake (all P trend < 0.05), whereas intakes of eggs and milk were associated with a decreased risk of breast cancer (both P trend <0.05). There was little evidence that associations with dietary intakes varied across the 4 tumor subtypes or between ER+/PR+ and ER-/PR- tumors (P for heterogeneity >0.05). Our results suggest that high intake of total vegetables, certain fruits, milk, and eggs may reduce the risk of breast cancer, whereas high consumption of animal-source foods may increase risk. The dietary associations did not appear to vary by ER/PR status. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/22860889/Fruit_vegetable_and_animal_food_intake_and_breast_cancer_risk_by_hormone_receptor_status_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2012.707277 DB - PRIME DP - Unbound Medicine ER -