Tags

Type your tag names separated by a space and hit enter

Diagnostic and prognostic value of subcutaneous tissue biopsy in patients with cardiac amyloidosis.
Am J Cardiol. 2012 Nov 15; 110(10):1507-11.AJ

Abstract

Cardiac involvement in systemic amyloidosis causes detrimental prognosis; therefore, early detection and classification are important to develop appropriate therapeutic strategies. Subcutaneous tissue biopsy is a useful screening procedure for systemic amyloidosis; however, its diagnostic and prognostic value in patients with cardiac amyloidosis remains elusive. Thus, we investigated the value of subcutaneous tissue biopsy in cardiac amyloidosis. In 22 patients with cardiac amyloidosis, we retrospectively analyzed 14 consecutive patients with cardiac amyloidosis who underwent subcutaneous tissue biopsy. Amyloid deposition was observed in 11 patients (79%). Histopathologic analysis demonstrated that acquired monoclonal immunoglobulin light-chain amyloidosis could be predicted when the degree of amyloid deposition was greater in blood vessels than adipose tissue compared to senile systemic amyloidosis and familial amyloidosis (60% vs 0%, p = 0.03). During the follow-up period (median 297 days, range 3 to 761), 7 patients (5 with monoclonal immunoglobulin light-chain amyloidosis and 2 with senile systemic amyloidosis) died or were admitted to the hospital because of worsening heart failure. Of them, 6 patients (86%) were positive for amyloid deposition in blood vessels in subcutaneous tissue biopsy. Incidence of death and composite outcome including heart failure hospitalization and death was significantly higher in patients positive for amyloid deposition in blood vessels than in those without (p = 0.03, p = 0.006, respectively). These results suggest that amyloid subtype could be diagnosed by assessing the degree of amyloid deposition in blood vessels and adipose tissue in subcutaneous tissue biopsy samples from patients with cardiac amyloidosis. Amyloid deposition in blood vessels suggests poor prognosis of these patients.

Authors+Show Affiliations

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22863178

Citation

Takashio, Seiji, et al. "Diagnostic and Prognostic Value of Subcutaneous Tissue Biopsy in Patients With Cardiac Amyloidosis." The American Journal of Cardiology, vol. 110, no. 10, 2012, pp. 1507-11.
Takashio S, Izumiya Y, Jinnin M, et al. Diagnostic and prognostic value of subcutaneous tissue biopsy in patients with cardiac amyloidosis. Am J Cardiol. 2012;110(10):1507-11.
Takashio, S., Izumiya, Y., Jinnin, M., Yamamuro, M., Kojima, S., Ihn, H., & Ogawa, H. (2012). Diagnostic and prognostic value of subcutaneous tissue biopsy in patients with cardiac amyloidosis. The American Journal of Cardiology, 110(10), 1507-11. https://doi.org/10.1016/j.amjcard.2012.06.059
Takashio S, et al. Diagnostic and Prognostic Value of Subcutaneous Tissue Biopsy in Patients With Cardiac Amyloidosis. Am J Cardiol. 2012 Nov 15;110(10):1507-11. PubMed PMID: 22863178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic and prognostic value of subcutaneous tissue biopsy in patients with cardiac amyloidosis. AU - Takashio,Seiji, AU - Izumiya,Yasuhiro, AU - Jinnin,Masatoshi, AU - Yamamuro,Megumi, AU - Kojima,Sunao, AU - Ihn,Hironobu, AU - Ogawa,Hisao, Y1 - 2012/08/03/ PY - 2012/04/09/received PY - 2012/06/25/revised PY - 2012/06/25/accepted PY - 2012/8/7/entrez PY - 2012/8/7/pubmed PY - 2013/1/9/medline SP - 1507 EP - 11 JF - The American journal of cardiology JO - Am J Cardiol VL - 110 IS - 10 N2 - Cardiac involvement in systemic amyloidosis causes detrimental prognosis; therefore, early detection and classification are important to develop appropriate therapeutic strategies. Subcutaneous tissue biopsy is a useful screening procedure for systemic amyloidosis; however, its diagnostic and prognostic value in patients with cardiac amyloidosis remains elusive. Thus, we investigated the value of subcutaneous tissue biopsy in cardiac amyloidosis. In 22 patients with cardiac amyloidosis, we retrospectively analyzed 14 consecutive patients with cardiac amyloidosis who underwent subcutaneous tissue biopsy. Amyloid deposition was observed in 11 patients (79%). Histopathologic analysis demonstrated that acquired monoclonal immunoglobulin light-chain amyloidosis could be predicted when the degree of amyloid deposition was greater in blood vessels than adipose tissue compared to senile systemic amyloidosis and familial amyloidosis (60% vs 0%, p = 0.03). During the follow-up period (median 297 days, range 3 to 761), 7 patients (5 with monoclonal immunoglobulin light-chain amyloidosis and 2 with senile systemic amyloidosis) died or were admitted to the hospital because of worsening heart failure. Of them, 6 patients (86%) were positive for amyloid deposition in blood vessels in subcutaneous tissue biopsy. Incidence of death and composite outcome including heart failure hospitalization and death was significantly higher in patients positive for amyloid deposition in blood vessels than in those without (p = 0.03, p = 0.006, respectively). These results suggest that amyloid subtype could be diagnosed by assessing the degree of amyloid deposition in blood vessels and adipose tissue in subcutaneous tissue biopsy samples from patients with cardiac amyloidosis. Amyloid deposition in blood vessels suggests poor prognosis of these patients. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/22863178/Diagnostic_and_prognostic_value_of_subcutaneous_tissue_biopsy_in_patients_with_cardiac_amyloidosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(12)01721-3 DB - PRIME DP - Unbound Medicine ER -