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Improvement of atopic dermatitis-like skin lesions by Platycodon grandiflorum fermented by Lactobacillus plantarum in NC/Nga mice.
Biol Pharm Bull. 2012; 35(8):1222-9.BP

Abstract

Atopic dermatitis (AD) is characterized as a multi-factorial inflammatory skin disease that has been increasing worldwide. Previously, we demonstrated that FPG, which is Platycodon grandiflorum (PG) fermented by Lactobacillus plantarum (LP), increases the level of interferon (IFN)-gamma in mouse splenocytes in vitro. In this study, we investigated the effects of FPG in an animal model of AD, with a particular emphasis on its effects on T helper (Th)1 and Th2 immune responses. To assess the potential use of FPG for the inhibition of AD, we established a model of AD-like skin lesions in NC/Nga mice. Immunoglobulin isotypes (Igs) and Th1/Th2 cytokines in the sera and spleens of AD-like mice were examined. In addition, histological examination was also performed. AD symptoms in skin lesions improved following oral administration of FPG. IgE secretion was significantly down-regulated, and this was accompanied by decreased levels of interleukin (IL)-4 and IgG1 and increased serum levels of IL-12p40 and IgG2a in FPG-treated animals. In splenocytes, the production of the Th1 cytokines IL-12p40 and IFN-gamma was up-regulated, while the levels of the Th2 cytokines IL-4 and 5 were down-regulated by FPG treatment. These results suggest that FPG inhibits the development of AD-like skin lesions in NC/Nga mice by suppressing the Th2 cell response and increasing the Th1 cell responses. Our results indicate that FPG is safe and effective for the prevention of AD-like skin lesions.

Authors+Show Affiliations

Research Institute of Atopy and Immunity, CombiMed Co., Ltd., Seocho-gu, Seoul 137–070, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22863917

Citation

Kim, Min-Soo, et al. "Improvement of Atopic Dermatitis-like Skin Lesions By Platycodon Grandiflorum Fermented By Lactobacillus Plantarum in NC/Nga Mice." Biological & Pharmaceutical Bulletin, vol. 35, no. 8, 2012, pp. 1222-9.
Kim MS, Kim WG, Chung HS, et al. Improvement of atopic dermatitis-like skin lesions by Platycodon grandiflorum fermented by Lactobacillus plantarum in NC/Nga mice. Biol Pharm Bull. 2012;35(8):1222-9.
Kim, M. S., Kim, W. G., Chung, H. S., Park, B. W., Ahn, K. S., Kim, J. J., & Bae, H. (2012). Improvement of atopic dermatitis-like skin lesions by Platycodon grandiflorum fermented by Lactobacillus plantarum in NC/Nga mice. Biological & Pharmaceutical Bulletin, 35(8), 1222-9.
Kim MS, et al. Improvement of Atopic Dermatitis-like Skin Lesions By Platycodon Grandiflorum Fermented By Lactobacillus Plantarum in NC/Nga Mice. Biol Pharm Bull. 2012;35(8):1222-9. PubMed PMID: 22863917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement of atopic dermatitis-like skin lesions by Platycodon grandiflorum fermented by Lactobacillus plantarum in NC/Nga mice. AU - Kim,Min-Soo, AU - Kim,Wan-Gi, AU - Chung,Hwan-Suck, AU - Park,Byoung-Woo, AU - Ahn,Kyoo-Seok, AU - Kim,Jeong-Jin, AU - Bae,Hyunsu, PY - 2012/8/7/entrez PY - 2012/8/7/pubmed PY - 2012/12/22/medline SP - 1222 EP - 9 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 35 IS - 8 N2 - Atopic dermatitis (AD) is characterized as a multi-factorial inflammatory skin disease that has been increasing worldwide. Previously, we demonstrated that FPG, which is Platycodon grandiflorum (PG) fermented by Lactobacillus plantarum (LP), increases the level of interferon (IFN)-gamma in mouse splenocytes in vitro. In this study, we investigated the effects of FPG in an animal model of AD, with a particular emphasis on its effects on T helper (Th)1 and Th2 immune responses. To assess the potential use of FPG for the inhibition of AD, we established a model of AD-like skin lesions in NC/Nga mice. Immunoglobulin isotypes (Igs) and Th1/Th2 cytokines in the sera and spleens of AD-like mice were examined. In addition, histological examination was also performed. AD symptoms in skin lesions improved following oral administration of FPG. IgE secretion was significantly down-regulated, and this was accompanied by decreased levels of interleukin (IL)-4 and IgG1 and increased serum levels of IL-12p40 and IgG2a in FPG-treated animals. In splenocytes, the production of the Th1 cytokines IL-12p40 and IFN-gamma was up-regulated, while the levels of the Th2 cytokines IL-4 and 5 were down-regulated by FPG treatment. These results suggest that FPG inhibits the development of AD-like skin lesions in NC/Nga mice by suppressing the Th2 cell response and increasing the Th1 cell responses. Our results indicate that FPG is safe and effective for the prevention of AD-like skin lesions. SN - 1347-5215 UR - https://www.unboundmedicine.com/medline/citation/22863917/Improvement_of_atopic_dermatitis_like_skin_lesions_by_Platycodon_grandiflorum_fermented_by_Lactobacillus_plantarum_in_NC/Nga_mice_ L2 - http://joi.jlc.jst.go.jp/DN/JST.JSTAGE/bpb/b110504?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -