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Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats.
Arch Pharm Res. 2012 Jul; 35(7):1241-50.AP

Abstract

In the present study, the protective effects of gypenosides from Gynostemma pentaphyllum on fatty liver disease (FLD) were examined in rats treated with high fat and cholesterol diet and alcohol. Male SD rats were divided into seven groups: control, model, lovastatin, silymarin, gypenosides high-, medium- and low-treatment groups. The latter 6 groups were fed high-fat and cholesterol diet and administered alcohol intragastricly once a day. Body weight was measured every week for 10 weeks, and the hepatic index was measured after 10 weeks. Compared with model group, levels of serum triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), and low density lipoprotein cholesterol (LDL-C) level, malondialdehyde (MDA), serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, and hepatocyte apoptosis were significantly decreased in gypenosides groups; while serum high density lipoprotein cholesterol (HDL-C), superoxide dismutase (SOD) activity in both serum and hepatic tissue and mRNA and protein level of peroxisome proliferator-activated receptor α (PPAR-α) were significantly increased. Moreover, hepatic steatosis and mitochondrial damage were improved. These results suggested that gypenosides could prevent liver fatty degeneration in fatty liver disease through modulating lipid metabolism, ameliorating liver dysfunction and reducing oxidative stress.

Authors+Show Affiliations

Hutchison Whampoa Guangzhou Baiyunshan modern Chinese Medicine Research Institute, Guangzhou 510515, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22864747

Citation

Qin, Renan, et al. "Protective Effects of Gypenosides Against Fatty Liver Disease Induced By High Fat and Cholesterol Diet and Alcohol in Rats." Archives of Pharmacal Research, vol. 35, no. 7, 2012, pp. 1241-50.
Qin R, Zhang J, Li C, et al. Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. Arch Pharm Res. 2012;35(7):1241-50.
Qin, R., Zhang, J., Li, C., Zhang, X., Xiong, A., Huang, F., Yin, Z., Li, K., Qin, W., Chen, M., Zhang, S., Liang, L., Zhang, H., Nie, H., & Ye, W. (2012). Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. Archives of Pharmacal Research, 35(7), 1241-50. https://doi.org/10.1007/s12272-012-0715-5
Qin R, et al. Protective Effects of Gypenosides Against Fatty Liver Disease Induced By High Fat and Cholesterol Diet and Alcohol in Rats. Arch Pharm Res. 2012;35(7):1241-50. PubMed PMID: 22864747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. AU - Qin,Renan, AU - Zhang,Jianyu, AU - Li,Chuyuan, AU - Zhang,Xiaoqi, AU - Xiong,Aihua, AU - Huang,Feng, AU - Yin,Zhen, AU - Li,Kongyan, AU - Qin,Wenyu, AU - Chen,Mingzhen, AU - Zhang,Shubing, AU - Liang,Lingyi, AU - Zhang,Huiye, AU - Nie,Hong, AU - Ye,Wencai, Y1 - 2012/08/03/ PY - 2011/08/04/received PY - 2011/12/27/accepted PY - 2011/12/20/revised PY - 2012/8/7/entrez PY - 2012/8/7/pubmed PY - 2012/12/19/medline SP - 1241 EP - 50 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 35 IS - 7 N2 - In the present study, the protective effects of gypenosides from Gynostemma pentaphyllum on fatty liver disease (FLD) were examined in rats treated with high fat and cholesterol diet and alcohol. Male SD rats were divided into seven groups: control, model, lovastatin, silymarin, gypenosides high-, medium- and low-treatment groups. The latter 6 groups were fed high-fat and cholesterol diet and administered alcohol intragastricly once a day. Body weight was measured every week for 10 weeks, and the hepatic index was measured after 10 weeks. Compared with model group, levels of serum triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), and low density lipoprotein cholesterol (LDL-C) level, malondialdehyde (MDA), serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, and hepatocyte apoptosis were significantly decreased in gypenosides groups; while serum high density lipoprotein cholesterol (HDL-C), superoxide dismutase (SOD) activity in both serum and hepatic tissue and mRNA and protein level of peroxisome proliferator-activated receptor α (PPAR-α) were significantly increased. Moreover, hepatic steatosis and mitochondrial damage were improved. These results suggested that gypenosides could prevent liver fatty degeneration in fatty liver disease through modulating lipid metabolism, ameliorating liver dysfunction and reducing oxidative stress. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/22864747/Protective_effects_of_gypenosides_against_fatty_liver_disease_induced_by_high_fat_and_cholesterol_diet_and_alcohol_in_rats_ L2 - https://dx.doi.org/10.1007/s12272-012-0715-5 DB - PRIME DP - Unbound Medicine ER -