Citation
Jeon, In Hwa, et al. "Inhibitory Effect of Dibutyryl Chitin Ester On Nitric Oxide and Prostaglandin E₂ Production in LPS-stimulated RAW 264.7 Cells." Archives of Pharmacal Research, vol. 35, no. 7, 2012, pp. 1287-92.
Jeon IH, Mok JY, Park KH, et al. Inhibitory effect of dibutyryl chitin ester on nitric oxide and prostaglandin E₂ production in LPS-stimulated RAW 264.7 cells. Arch Pharm Res. 2012;35(7):1287-92.
Jeon, I. H., Mok, J. Y., Park, K. H., Hwang, H. M., Song, M. S., Lee, D., Lee, M. H., Lee, W. Y., Chai, K. Y., & Jang, S. I. (2012). Inhibitory effect of dibutyryl chitin ester on nitric oxide and prostaglandin E₂ production in LPS-stimulated RAW 264.7 cells. Archives of Pharmacal Research, 35(7), 1287-92. https://doi.org/10.1007/s12272-012-0720-8
Jeon IH, et al. Inhibitory Effect of Dibutyryl Chitin Ester On Nitric Oxide and Prostaglandin E₂ Production in LPS-stimulated RAW 264.7 Cells. Arch Pharm Res. 2012;35(7):1287-92. PubMed PMID: 22864752.
TY - JOUR
T1 - Inhibitory effect of dibutyryl chitin ester on nitric oxide and prostaglandin E₂ production in LPS-stimulated RAW 264.7 cells.
AU - Jeon,In Hwa,
AU - Mok,Ji Ye,
AU - Park,Kwang-Hyun,
AU - Hwang,Hee Min,
AU - Song,Mi Seon,
AU - Lee,Duckhee,
AU - Lee,Min Hee,
AU - Lee,Woo-Yiel,
AU - Chai,Kyu Yun,
AU - Jang,Seon Il,
Y1 - 2012/08/03/
PY - 2011/11/22/received
PY - 2012/03/19/accepted
PY - 2012/03/09/revised
PY - 2012/8/7/entrez
PY - 2012/8/7/pubmed
PY - 2012/12/19/medline
SP - 1287
EP - 92
JF - Archives of pharmacal research
JO - Arch Pharm Res
VL - 35
IS - 7
N2 - Inflammation is a highly complex process that protects against foreign challenge or tissue injury. The ester derivative dibutyryl chitin (DBC) reportedly accelerates wound healing and exerts an anti-inflammatory effect. However, little is known regarding the inhibitory effect of DBC in anti-inflammation. In this study, we investigated the effect of DBC on the inducible nitric oxide synthetase (iNOS) and cyclooxygenage-2 (COX-2) pathways and pro-inflammatory cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Our results demonstrate that DBC (MW 3,772) significantly inhibits overproduction of NO and PGE(2) as well as pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-1β, in LPS-stimulated RAW 264.7 macrophages. Inhibition of NO and PGE(2) overproduction in LPSstimulated RAW 264.7 macrophages by DBC was mediated through the down-regulation of iNOS and COX-2 expression. These results demonstrate that DBC efficiently inhibits inflammation and has potential as an effective anti-inflammatory and wound healing agent.
SN - 0253-6269
UR - https://www.unboundmedicine.com/medline/citation/22864752/Inhibitory_effect_of_dibutyryl_chitin_ester_on_nitric_oxide_and_prostaglandin_E₂_production_in_LPS_stimulated_RAW_264_7_cells_
L2 - https://dx.doi.org/10.1007/s12272-012-0720-8
DB - PRIME
DP - Unbound Medicine
ER -
