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The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1.
Age (Dordr). 2013 Oct; 35(5):1559-74.A

Abstract

Nutraceuticals are known to have numerous health and disease preventing properties. Recent studies suggest that extracts containing cranberry may have anti-aging benefits. However, little is known about whether and how cranberry by itself promotes longevity and healthspan in any organism. Here we examined the effect of a cranberry only extract on lifespan and healthspan in Caenorhabditis elegans. Supplementation of the diet with cranberry extract (CBE) increased the lifespan in C. elegans in a concentration-dependent manner. Cranberry also increased tolerance of C. elegans to heat shock, but not to oxidative stress or ultraviolet irradiation. In addition, we tested the effect of cranberry on brood size and motility and found that cranberry did not influence these behaviors. Our mechanistic studies indicated that lifespan extension induced by CBE requires the insulin/IGF signaling pathway and DAF-16. We also found that cranberry promotes longevity through osmotic stress resistant-1 (OSR-1) and one of its downstream effectors, UNC-43, but not through SEK-1, a component of the p38 MAP kinase pathway. However, SIR-2.1 and JNK signaling pathways are not required for cranberry to promote longevity. Our findings suggest that cranberry supplementation confers increased longevity and stress resistance in C. elegans through pathways modulated by daf-16 and osr-1. This study reveals the anti-aging property of widely consumed cranberry and elucidates the underpinning mechanisms.

Authors+Show Affiliations

Department of Biological Sciences, Clemson University, Clemson, SC, 29634, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

22864793

Citation

Guha, Sujay, et al. "The Longevity Effect of Cranberry Extract in Caenorhabditis Elegans Is Modulated By Daf-16 and Osr-1." Age (Dordrecht, Netherlands), vol. 35, no. 5, 2013, pp. 1559-74.
Guha S, Cao M, Kane RM, et al. The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordr). 2013;35(5):1559-74.
Guha, S., Cao, M., Kane, R. M., Savino, A. M., Zou, S., & Dong, Y. (2013). The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. Age (Dordrecht, Netherlands), 35(5), 1559-74. https://doi.org/10.1007/s11357-012-9459-x
Guha S, et al. The Longevity Effect of Cranberry Extract in Caenorhabditis Elegans Is Modulated By Daf-16 and Osr-1. Age (Dordr). 2013;35(5):1559-74. PubMed PMID: 22864793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. AU - Guha,Sujay, AU - Cao,Min, AU - Kane,Ryan M, AU - Savino,Anthony M, AU - Zou,Sige, AU - Dong,Yuqing, Y1 - 2012/08/04/ PY - 2012/02/10/received PY - 2012/07/11/accepted PY - 2012/8/7/entrez PY - 2012/8/7/pubmed PY - 2014/5/21/medline SP - 1559 EP - 74 JF - Age (Dordrecht, Netherlands) JO - Age (Dordr) VL - 35 IS - 5 N2 - Nutraceuticals are known to have numerous health and disease preventing properties. Recent studies suggest that extracts containing cranberry may have anti-aging benefits. However, little is known about whether and how cranberry by itself promotes longevity and healthspan in any organism. Here we examined the effect of a cranberry only extract on lifespan and healthspan in Caenorhabditis elegans. Supplementation of the diet with cranberry extract (CBE) increased the lifespan in C. elegans in a concentration-dependent manner. Cranberry also increased tolerance of C. elegans to heat shock, but not to oxidative stress or ultraviolet irradiation. In addition, we tested the effect of cranberry on brood size and motility and found that cranberry did not influence these behaviors. Our mechanistic studies indicated that lifespan extension induced by CBE requires the insulin/IGF signaling pathway and DAF-16. We also found that cranberry promotes longevity through osmotic stress resistant-1 (OSR-1) and one of its downstream effectors, UNC-43, but not through SEK-1, a component of the p38 MAP kinase pathway. However, SIR-2.1 and JNK signaling pathways are not required for cranberry to promote longevity. Our findings suggest that cranberry supplementation confers increased longevity and stress resistance in C. elegans through pathways modulated by daf-16 and osr-1. This study reveals the anti-aging property of widely consumed cranberry and elucidates the underpinning mechanisms. SN - 1574-4647 UR - https://www.unboundmedicine.com/medline/citation/22864793/The_longevity_effect_of_cranberry_extract_in_Caenorhabditis_elegans_is_modulated_by_daf_16_and_osr_1_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22864793/ DB - PRIME DP - Unbound Medicine ER -