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Familial colon cancer syndromes: an update of a rapidly evolving field.
Curr Gastroenterol Rep. 2012 Oct; 14(5):428-38.CG

Abstract

Colorectal cancer (CRC) is a major cause of morbidity and mortality in the world. Up to 30 % of CRCs have evidence of a familial component, and about 5 % are thought to be due to well-characterized inherited mutations. This review will focus on recent developments in the understanding of the individual hereditary CRC syndromes, including Lynch syndrome, familial CRC type X, familial adenomatous polyposis, MutYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis syndrome, PTEN hamartomatous syndrome, and serrated polyposis syndrome. Advances within the area of hereditary colon cancer syndromes paint a picture of a rapidly moving, rapidly maturing, and increasingly collaborative field with many opportunities for ongoing research and development.

Authors+Show Affiliations

University of Colorado School of Medicine, Aurora, CO 80045, USA. Swati.Patel@ucdenver.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22864806

Citation

Patel, Swati G., and Dennis J. Ahnen. "Familial Colon Cancer Syndromes: an Update of a Rapidly Evolving Field." Current Gastroenterology Reports, vol. 14, no. 5, 2012, pp. 428-38.
Patel SG, Ahnen DJ. Familial colon cancer syndromes: an update of a rapidly evolving field. Curr Gastroenterol Rep. 2012;14(5):428-38.
Patel, S. G., & Ahnen, D. J. (2012). Familial colon cancer syndromes: an update of a rapidly evolving field. Current Gastroenterology Reports, 14(5), 428-38. https://doi.org/10.1007/s11894-012-0280-6
Patel SG, Ahnen DJ. Familial Colon Cancer Syndromes: an Update of a Rapidly Evolving Field. Curr Gastroenterol Rep. 2012;14(5):428-38. PubMed PMID: 22864806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Familial colon cancer syndromes: an update of a rapidly evolving field. AU - Patel,Swati G, AU - Ahnen,Dennis J, PY - 2012/8/7/entrez PY - 2012/8/7/pubmed PY - 2013/2/13/medline SP - 428 EP - 38 JF - Current gastroenterology reports JO - Curr Gastroenterol Rep VL - 14 IS - 5 N2 - Colorectal cancer (CRC) is a major cause of morbidity and mortality in the world. Up to 30 % of CRCs have evidence of a familial component, and about 5 % are thought to be due to well-characterized inherited mutations. This review will focus on recent developments in the understanding of the individual hereditary CRC syndromes, including Lynch syndrome, familial CRC type X, familial adenomatous polyposis, MutYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis syndrome, PTEN hamartomatous syndrome, and serrated polyposis syndrome. Advances within the area of hereditary colon cancer syndromes paint a picture of a rapidly moving, rapidly maturing, and increasingly collaborative field with many opportunities for ongoing research and development. SN - 1534-312X UR - https://www.unboundmedicine.com/medline/citation/22864806/Familial_colon_cancer_syndromes:_an_update_of_a_rapidly_evolving_field_ L2 - https://dx.doi.org/10.1007/s11894-012-0280-6 DB - PRIME DP - Unbound Medicine ER -